Welcome to the Oncoalert eCancer weekly round
up
Out on European Urology
Study comparing dd-MVAC Vs.
Gem Cis in Muscle invasive Bladder cancer
sees that the toxicity was manageable
Patients with muscle invasive bladder cancer
treated with neoadjuvant cisplatin who had
at least one mutation in 3 DNA damage repair
genes survived longer after cystectomy
Uromigos paper of the month out on Lancet
Oncology
CABOZANTINIB has single-agent clinical activity
in patients with heavily pretreated, platinum-refractory
metastatic urothelial carcinoma
Randomized clinical trial of patients with
HR-positive, ERBB2-negative Metastatic breast
cancer,
Addition of pembro to eribulin did not improve
PFS, ORR, or OS
Out on journal of global oncology
How has the pandemic influenced decision-making
by oncologists around the world
The WHO releases guidelines on corticosteroids
Advising use only in severe or critical infections
Out at European Journal of Cancer
new prognostic and predictive tool for shared
decision making in stage III colon cancer
assess the relative contributions of surgery
and adjuvant chemo for DFS
On cancer discovery
Great Review on: improvements in Clinical
Outcomes for #BRAFV600E
Mutant Metastatic #ColorectalCancer
“combos of BRAF, MEK & EGFR inhibitors are
now recommended by guidelines”
Jama Oncology
KEYNOTE-062 in untreated, advanced Gastric/Gastro
esophageal junction cancer
pembro was noninferior to chemo with fewer
adverse events
CAPMATINIB has substantial antitumor activity
in advanced non small cell lung cancer with
Met exon14 skipping mutations
Out on New England
First-line treatment with DABRAFENIB plus
TRAMETINIB lead to long-term benefit in approximately
one third of unresectable or metastatic melanoma
with a BRAF V600E or V600K mutation.
Out on JCO
insights on the biology underneath differential
efficacy of PARP inhibitors in #prostatecancer
with BRCA1 vs. BRCA2 mutations
Out on nature
Charles Swanton & team on
Pervasive chromosomal instability and karyotype
order in tumour evolution
Vivek Subbiah puts out an amazing tweetorial
to explaining the importance of BRAF V600E
in melanoma and non melanoma Solid tumors
In the New England
Summary of the past 50 years of progress in
cancer research, prevention and care
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Thats it folks your weekly round up, see you
next week
