So good morning, evening, afternoon. Yes
today we are going to talk a little bit
about quercetin. I had promised to do
that. Before that, I talk a little bit more about
chloroquine, clarify some of the things
come out up there. But I am going to
cover a couple of times some emotional
components, and it's not just emotional
components. These are life or death 
components. Boris Johnson came out and
said, look, you must stay at home. 20% of
the world's population right now
is on a significant lockdown. The UK is
not used to that. He said basically don't
do any of this except for shopping, for
groceries, essentials, medical need, one
form of exercise per day, traveling to
and from work if it's absolutely
necessary that you not work from home.
Again, as usual, the images aren't graphic
here, but things don't look good right
now. I think we should acknowledge that
you know you've seen it, we've also seen,
most of us. If you haven't seen this meme
then or this cartoon, you should have
seen it before. It's that frog who's
is about to be swallowed by the stork,
and you know where that's coming from.
But then we talk about doing anything.
You can not to give up.
Well that sounds cute unless you're the
frog, and a lot of people are saying you
know what, it's just not reality. Well
here's the thing.
Neville Chamberlain said that.. what
Winston Churchill said was not reality.
The German war machine prior to World
War 2 or at the beginning of World War
2, it marched all the way through
France and was ready to take over the
world starting with Europe. Winston
Churchill said, never give up, and it
turned out even though he was being
totally unrealistic by all rational
moments minds at the moment, he was right.
Now what we do over the next three weeks
to a month is going to be very important.
It will depend... it will determine who's
going to be here next Christmas, 
Ramadan, Hanukah. Again the decisions that
we make
the next few weeks, and I'll go a little
bit deeper in talking about that, and
give some personal examples with myself,
with my own family,
other members. Some viewers that have
made comments... I don't usually recommend...
I'm not an anarchist but sometimes you
get some advice that from authority
figures that may not be the greatest. I
don't think we're gonna end up having a
statement that we really should stop
social distancing over the next week. If
we do, I would ask you to reconsider.
Again, the next two to four weeks... I mean
this is a this is a 100-year
outbreak, a 100-year epidemic. Those
of us who swim in these waters focus on
epidemic management deal with public
health preventive medicine. We've been
waiting for this, and again, if you don't
believe that, just get the book by Osterholm,
Michael Osterholm, chapter 13,
Deadliest Enemy. He predicted this whole
thing. And again he's not alone. It's been
predicted. We've known it was coming. A
lot of warning signals were sent out, but
obviously they weren't heeded the way
they could have been. Had they been, there
would be a lot more people alive right
now.
And guess what. There's still time for a
whole lot of us and where most of us
will be here. Not all of us will be here
next holiday, but most of us will. And
who's here depends a lot on the actions
that we take over the next again 2 to
4 weeks. This 2- to 4-week period
is going to be critical in terms of our
survival. And it's really not going to
depend on zinc-quercetin. It's not going
to depend on is it from Zpak.
It's not going to depend on chloroquine
and hydroxychloroquine. Those might help
in some situations. It's not even going
to really depend on testing at this
point. Again at this point, it's going to
depend on whether or not you're in a
position of getting the virus. It's all
about transmission right now. Speaking of
transmission, there's a great article in
the New England Journal this week about
early transmission dynamics. Again it's
one of these many articles sent. A lot of
this great research,
what's been happening... happened at
the original epicenter in Wuhan the
first few weeks by some great
epidemiologist, some great Chinese
doctors that were there and recorded
what happened. So what did they do?
Early Transmission Dynamics in Wuhan
China. They collected information on
demographic characteristics, exposure
history, and illness timelines of the
laboratory confirmed cases. There are 425
patients in this original study. The
median age was 59 years. And you know
you keep hearing well it's mostly males,
it's predominantly male. It's a lot of
males, 56% males. It's not... I mean it's not
that big of a focus. The majority of
these cases were onset before January 1
of this year and we're linked to the
Huanan Safood Wholesale Market
as compared with 8.6 of the subsequent
cases. So yes that's where the finger
point or the pin point on that, that wet
market happened. Here's the critical
piece. The mean incubation period - 5.2
days in the 95th percentile distribution
at 12.5 days.
Let me repeat that results of the 425
patients. The mean incubation period was
5.2 days in the 95%. On 95th
percentile of the distribution was 12.5.
So what does that mean and why is that
important for us right now? What can we
learn from that? Well I'm gonna go into
personal examples about going into
social distancing, isolation and going
back out to get groceries. When did you
go out to get groceries last? When's
your next trip to the groceries? You've
got a 19 and 20 chance of knowing
whether or not you... if you're gonna get
this if you got this the last time you
were at the grocery store. You're gonna
know within about 2 weeks. So that's
one of the reasons that I keep saying
the next 2 to 4 weeks are critical.
The other reasons why I say that, I'll
talk about in just a minute, and
let's do that right now. Here's my
another of the reasons why I say the
next 2 weeks are critical. Here's the
the map, it's a little bit easier to
follow, and right now the Hopkins
COVID-19 tracker keeps spinning
on me. It's I think it's struggling right
now to keep up or there may be a problem
with it.
This one is this Bing tracker gives you
a little bit more headlines, a little bit
more of the news, and it gives you some
information that is helpful to know
about what's going on with the disease
in this pandemic, in this world right
now. As you see, obviously, the big the big
red dot in China, growth in the Middle
East, and the big red dot in Iran,
Italy in Europe, again the epicenter of
active cases right now. But as we said
yesterday, it appears to me that the
perhaps the epicenter of transmission
may be the United States at this point.
Look at the increase in cases. This was
back when that when it was in Wuhan in
China, and again this is just what's
happening now what 30 to 35
new cases each day 30 to 35
thousand new cases each day for the past
three days. So again, what you do when you
consider these numbers and what's going
on in the world outside your home
especially if you're in the US right
now. What you do over the next 2 to
4 weeks is critical to which
whether you and your.. which of you and
your family members are here over the
next holiday period. So again be careful
about this, to be careful about the
assumptions that you make. And I'll get a
little bit deeper into some of those
assumptions. I've been making the rounds
calling my family members and just
checking on their assumptions, and we get
some interesting ones, some of the
decisions that we make to get out.
They're not so easy. For example, health
care workers or food supply workers,
grocery workers, if they don't go to work,
the food supply shuts down.
Friends, I've got people who are helping
set up national coronavirus testing
programs. If they don't do their work, the
testing programs don't happen. But if the
testing programs don't happen, then we
can't find clusters, we can't find
outbreaks, we can't find places to
quarantine, and this killer continues to
ripple through the population. Again
mostly from people that have no clue
that they have any infection. They're not
symptomatic. They don't have symptoms.
They don't know that they were even
exposed So go back through some of the
things that we plan to cover of the rest
of the presentation. As I promised
a couple of times, yes, a lot of questions
and focus about zinc-quercetin. I looked
up a few things on zinc-quercetin and
I'll cover some quercetin questions. What
it is, why it's interesting, why it's... why
why a lot of people are asking about
it. I'll talk about the new source for
hydroxychloroquine - fish tank cleaning
supplies. Don't do it by the way It's
already killed a couple of people. And
again talk a little bit more about
family decisions, testing updates, thing
like things like that. So
quercetin. Why is quercetin a big issue
right now? What's the... what's the deal
behind quercetin? So coronavirus hijacks
our genetic cells. Genetic materials
so we use DNA - it's the head, the
the control center of the cell. It tells
us what proteins to make, and then the
proteins do the work. So the genetics
within the cell are the DNA or the
genetic material that's always the case
no matter which biological entity you're
looking at or species. Now again a virus
is really just a usually protein quoting
coding capsule with some genetic
material in it. It's almost like a
hypodermic, and inside that hypodermic,
there's genetic material that goes into
your cell, and it hijacks your own
genetic material. So what this
coronavirus do,
it goes in and shuts down some of
our DNA genetic mechanisms and takes it
over for its own RNA. It's an RNA virus.
You don't need to know the differences
between DNA and RNA, but it hijacks again
our genetic mechanisms to start making
RNA which in turn makes more and more
copies of the coronavirus shell in
the coronavirus RNA and then it
assembles those to fuse those back out
And now instead of having the virus that
are very on that infected, the cell now...
there are tens, thousands, millions of
them to go back out and infect other
cells. Now in order to do that, there's an
enzyme that it needs to hijack
this and start increasing the RNA
production. That enzyme, again geeky long
geeky term, RNA dependent RNA polymerase.
Now here's the thing. Zinc slows down
that enzyme. It inhibits the RNA
polymerase. So where does quercetin come
in? That's zinc, right? So zinc is an ion.
It's got a 2+ for the chemists
out there, and ions don't go very well
through cell membranes. Cell membranes
are mostly made of cholesterol. That's
where some of these people you hear, some
of these people say cholesterol is not
bad. In fact, it's a major building block.
(Pardon me for touching my face.) So what
do you do then? How does this zinc can we
stop the virus? Well, if we could get a
lot of zinc into that cell through that
cell membrane, we would slow down that
RNA dependent RNA polymerase and slow
down this process. So that's why so many
people are asking about this. You
see it turns out that quercetin is an
ionophore. Ionophores actually helped get
those ions through those cell membranes
and I may have misspelled there, fact
check me and correct me if I did.
Speaking of ionophores, that's where
chloroquine, hydroxychloroquine come
in.
We'll talk about those again a little
bit later. So here is quercetin, the
molecular structure on the left.
Chloroquine and hydroxychloroquine
election molecular structures on the
right. You know they sort of look like
chicken wire, right? I didn't have time. I
meant to go ahead and get yet another
molecular structure to show you. Many of
the chemists and biologists know where
I'm going already. The classic quote
chicken wire molecule is cholesterol so
these look a little bit like a
cholesterol molecule. They are
reminiscent maybe that has something to
do with getting zinc as an ionophore
process through that cholesterol
membrane. That's why there's so much
focus. And yes, quercetin is not
new. It's something that's been used for
quite a while. The research is not that
great yet on most things, but there is
some significant bigness within the
science. That quercetin is an
anti-inflammatory, used for cardiovascular
inflammation, used for immunity, and
especially I think for bladder cancer.
Very interesting components with
quercetin. What is it? It's a what's called
a plant flavonoid. What's the flavonoid? I
think I might skip that for right now.
What's it used for? Again, as we mentioned
before, heart and vessel problems,
lowering blood pressure, prostate
infections, preventing upper respiratory
infections, allergies, disease prevention.
Why do people take it? Again, that's
why they take it. Soes it work? Again
there's some moderate science signals
out there. Somebody asked me yesterday
how much do you take when you do take it?
The standard that you tend to see with
most of these supplements is 500
milligrams per day, and as I mentioned
here, there's some fairly good hard
science regarding anti-cancer and anti
metastases functions for human bladder,
cell cancers. Flavus. What does flavus
mean? Flavus is a Latin word for yellow.
These are for the chemists. They're
polyphenols, and they're basically
metabolites from other plant processes.
As you've seen, as I've been going
these slides. There's a bunch of
different sources for it. You see it a
lot in different fruits and vegetables.
Each of these pictures that I'm showing
on the side here are plant sources for
flavonoids. They have two phenyl rings
and a heterocyclic ring for again for
the chemistry geeks. We'll look later and
see if we have a lot of questions or
concerns or other issues about
flavonoids and zinc-quercetin. Now let's
go back to something we've mentioned
before. So quercetin, yeah, it may help. Is
it worth going to the grocery store to
get quercetin? I don't think so. Am I
gonna leave and go get quercetin? No. Do I
have quercetin at home now? I do have some
zinc. Again as I mentioned yesterday, one
of our volunteers sent me some zinc.
Someone was asking recently which
salt is it? So you've got cations and
anions. The cations have the T in them so
that they have a positive charge. The
anions have a negative charge, they have
an N in them. The anion on this one is
zinc gluconate. Do I know specifically
that that is the best one? I don't. Am i
spending a lot of time investigating
that? Frankly, I'm not because what am I
spending my time on I'm spending my time
talking with friends, families, and loved
ones people that I work with and asking
them some questions about their
assumptions right now and we'll get into
those assumptions. Someone asks yesterday,
well, what about hydroxychloroquine and
azithromycin in the Zpak and
those of you who heard the President of
the United States. I believe it was last
night he was praising that combination,
talking about how great that was going
to be. Some people have had died from it
already as one of our friends, one of our
viewers pointed out yesterday. Both of
these drugs are known to prolong the QT
interval. It's the time that they
charge the contraction of the heart. The
electrical beat goes from the Q which is
the beginning of the beat in the
ventricles or the signal to beat in the
ventricles and then the T which is
depolarization. Bottom line is, yes, this
is not a an innocuous drug,
hydroxychloroquine. This
evidently found out that
hydroxychloroquine was in there, the
chemical used to clean their fish tank.
So they decided to take it
prophylactically. I've mentioned that
I've prescribed hydroxychloroquine in a
couple of situations. I'm not encouraging
taking hydroxychloroquine
prophylactically except in some fairly
unusual conditions like health care
providers and again not
prophylactically in all health care
providers and I think that still might
be off-label right now. I would be very
concerned, very nervous about using it. As
we've said, there have been deaths
already. Back to the real issue,
the most important issue for all of us
right now during this ugly 2 to 4
week period, I'm not saying we're even
going to get out at the end of 2 to
4 weeks. What I am saying is that
we'll know we'll be in a very different
world 2 to 4 weeks from there. So we
know we're going into that space, the
most important 2 to 4 weeks of this
100-year experience. So really be
focused, really be thinking about this.
Don't think so much about zinc-quercetin.
Don't think so much about supplements.
Don't think so much about dog food. Don't
think so much about groceries. Don't
think so much about if you'd like to see
your family members right now.
Well, all of those are very important
things. Please think about getting
through as much as you can for the next
2 to 4 weeks with as little
potential exposure as you can because
again they're going to be critical waste
in terms of avoiding this virus. So we
had a viewer yesterday who said is it
worth it? I'm miserable, I want to see my
family. I've been out here. And he
didn't explain where he was, he didn't
explain why he's been out here, he
didn't explain why I could not see his
family. But again, for the next 2 weeks,
um don't most sense because we haven't
had a situation in this world for a
hundred
and what 102 years that we have right
now. When was the last time there was a
very real real possibility of dying as
going dying as a result of going to the
grocery store? Dying is the result of
shaking hands from someone. Dying is the
result of going to get gasoline in your
car. Now of course, yes, there's a
possibility of dying in car wrecks and
things like that. And of course, we could
always get run over by a bus. But those
were not practical considerations. The
last time this was a practical
consideration was 102 years ago, 1918
with the Spanish flu. Speaking of
family members locked away in the
in the lake house. This was one group I
talked to. There's a 70-year-old male, 67-
year-old female, 89-year-old female. All
of that was good. They had... they were...
they also had a 15-year-old male
and a 12-year-old female. There was also
a mother in the generation in between
those two generations actually. There are
four generations there, and I began to
ask the question, okay, so where's the mom
the 30-year-old, and the answer was well
she brought the two kids in a couple of
days ago. So I'm going back to the New
England Journal article. So okay, so
they've had a couple of days, 5 days
is the median if they
brought infection with them so they
could... clearly no evidence at
this point that we don't have infection.
And again, it's going to be what it's
going to be 2 weeks of them being
isolated before we know for sure that
they haven't had exposure to this virus.
So then you next ask the next question.
Well, and by the way, the mom's coming to
pick the kids up again in a couple more
days. (I know I'm touching my hands, I know
I'm doing things that I
shouldn't do either.) But again I start to
get concerned about, is that worth it? And
here's the next question. How about dad?
Dad is working in a factory going in
every day. And yes of course, they're
taking temperatures. But dad's working in
a factory. What is the factory? Let's make
an assumption that if
acess for Tyvek and that that tab
Tyvek is being used now to make gowns
for PPE personal protective equipment.
But it's important for mom to see dad
right? And it's important for mom to see
the kids, right? And it's important for
the kids to stay isolated with grandma
and granddad and great-grandma. Let's
again consider that it's never been the
case for a hundred years, but it is the
case over the next 2 to 4 weeks.
This kind of mixing can result in
transmission of this virus. So let's
reconsider our assumptions, call another
one. Oh we've been locked in for three
weeks, we're good, and we actually well
went went went to get groceries last
week a couple of days ago, and forgot to
get dog food. So I'm gonna have to go
back in in a couple of days and I'm
going. It's great that we're
locked in, and we've got enough food for
3 weeks but how about the dogs
eating table scraps for a few weeks? I
mean just this next 2 to 4 weeks,
guys, and had silence for a few minutes.
And they said, well, I've got four dogs, we
don't have that many table scraps. You
know well maybe we could think a little
bit more about that and again sure
enough I got a text a while back a little
bit little hearsay. Come on thank you
bringing that out. We ordered that. We
ordered delivery for dog food. Speaking
of which, you know, what about delivery,
what about things so I'm still ordering
things about delivery instead of going
to some place like a grocery store? I'm
still living off of mostly olive oil and
avocado oil and putting it on different
things to sort of help change the taste.
Janice's getting things at the grocery
which I'm not too happy about
obviously. And you know what? The first
time she got groceries, neither one of us
thought about wiping things
off after she brought him in. She did
think about not touching the bags and
after we thought about it later, there's
a lot more risk from what's in the groceries
from the covers of the groceries than
what's in the bags.
This is totally unprecedented and what
we do over the next 2 to 4 weeks
is going to be critical to our survival.
So please think about it. How about a
serving meat in a grocery store. This is
another person very near to us
still going into work every day 4 or
5 days a week at least, and oh no, we
started to raise the question of you
know what, why don't you develop a coffee
or why don't you consider whether or not
it's worth it? Because again, the next 2
to 4 weeks are critical. We had to cut,
we had to call back later on, and say, you
know what I've been in that
turn as well. I used to be an ER doc and
I would have gotten up and gone to work
so there are times we make decisions
that risk ourselves and our families. We
should just at least make it with full
knowledge, and I think if we're talking
about seeing mom and dad, we know we can
do within a few weeks for especially of
getting dog food or getting carbs
because we think we need to have carbs
in our diet or getting whatever whose
favorite. Reconsider whether those are
really necessary again for the next 2
to 4 weeks. Am I saying, and just as a
repetition, am I saying that we're gonna
be fine 2 to 4 weeks from now? No, I'm
not saying that. I am saying that the
picture will be very very different 2
to 4 weeks from now. You and I both
know that. So again think about the
assumptions that you're using to make
your decisions right now. Health care
workers are going with full-blown
diabetes are going into work. We know
that they're making some brave decisions
to sacrifice themselves or risk
sacrificing them to risk themselves to
help others to help their patients.
Public safety workers, public health
workers. James, my partner on that, one of
my partners on this national testing
program, he's getting a lot of
exposure right now sourcing gowns and
gloves and masks. So as I've said, this is
hard mistaken assumptions can kill us, and
the next few weeks are critical for our
survival. For those of you, of us who are
going to be around this coming holiday.
Question
is it safe to the group to go to the grocery
store or is it safe to go get the mail?
Is it safe to go to the coffee shop?
Speaking of an update on the testing
program, well, we got... I've been talking
with a lot of what's the word a lot of
confidence in our partners at the lab
that yes they've been consistent. We're
gonna have... no, we don't have labs today
but we will have lab kits this coming
Wednesday. Well today is Tuesday and last
night we heard, no, we don't have 10,000
lab kits available. We've got 5, and we
don't are not going to have 5,000, 10,000
a day available for you, and we're not
sure how many we're going to have
available. So even though it's a national
lab partner, even though they were
adamant and very sure and have been
consistent up until last night that they
were going to have lab kits starting
tomorrow,
doesn't look like that's happening right
now. And we've been working as I've
shared with you one of my own personal
risk concerns was I almost made the
decision to go out and make a training
film for whether people would be
delivering this test and doing the tests
sampling. I felt like it was... it might be
worth the risk. They were gonna... they've
got a 5,000 square foot studio. It was
going to be just me and a videographer,
and we're going to do the gown
donning and doffing, that's putting it on
you know, putting the stuff on the gown,
the gloves, the mask, and the
shield, and then taking them off. Then I
thought again, and I said, you know what,
these next 2 weeks are critical so
let's take the content that we already
have, take some content off of the
internet, and there are a bunch of
hospitals making a bunch of that content
right now on the internet. So we're going
to be taking that and using it, and we're
doing some things which will help and
improve this and make this high quality
video. But again, so then we got to get
the gowns to do some of this and
there are no gowns.
The hospitals have over-ordered their
suppliers, have over-ordered for them. You
know by the way, they're sourced from
China, from China.
These are all actually sourced from
China. And whether you know I heard
that president last night say that we're
breaking up and we've got palate after
palate after palate of the national
stock that we're releasing. Whether any
of those are true, I don't know. I mean, no
but are we gonna be up and rolling.
People are stockpiling, we're hearing
that, and yes our president's new best
friend frenemy was up announcing what
the Attorney General would do for
stockpiling and profiteering based on
this activity. But again, things are over-
ordered.
We're not accessing gloves, PPE, gowns, and
for sure N95 masks. I had a viewer
comment yesterday that she was helping
make N95 masks, sewing them herself, and
I just I thought that was interesting
neat, and it threw me for a second, but it
just showed me how out of touch I was
with what's going on with sourcing right
now. Just a brief comment about labs. Just
a reminder you hear a lot of stuff about
the immediate lab, the immediate lab, the
immediate lab the self-testing lab. I get
a lot of questions about that.
That's an antibody test. It's similar to
what you see with the home pregnancy
test. It's gonna be great when we get
past the next 2 to 4 weeks or maybe
longer
because then questions gonna be very
very different. It's gonna, when can I
come out. We're gonna be, it's like spring
is going to you know the nuclear winter
is gonna have gone and spring is coming
out. And we're actually beginning to
start thinking about when can we come
out, when we reconfigure, restart the
economy, when can we restart our lives.
And at that point, we want to know if we
have an antibody, right? Now that's not
that helpful right now. We need to know
who's got the virus. And those are two
different things. If you go back, you
remember it's up to 2 weeks before
people start the incubation period. Now
what's not clear
and what was not shown in that was how
long does it take you from the time of
infection to the time that you form an
antibody. Here's the big question. How
much virus do you have building up in
your body before you show a positive
antibody that is the critical question
for us at this stage in the pandemic and
we don't know the answer to that yet. Why
are we using the other tests? That's why
if the test is called PCR polymerase
chain reaction, it's basically looking at
the DNA or the genetic material which is
actually RNA that we talked about in the
very beginning of this discussion. The
RNA for coronavirus we're looking at PCR,
that takes a couple of days. How you do
that lab? It's this. You take the sample out,
you put it in in areas, you add some
things to and heat it up, incubate it in
it that polymerase chain reaction,
creates more and more of that, growing
the virus RNA. Again, that's where some of
the problem, gets back to test kit issues
the CDC is responsible when these types
of epidemics come through. They're
responsible for sourcing the actual
infectious agent, breaking it down,
developing DNA tests which were our
(excuse me) genetic material tests which
will help us detect that virus.
Once we implement in lab and that's what
we're all waiting for in terms of those
testing. So don't really... I don't know. I
haven't seen anybody getting access yet.
I think if people were out there
accessing the antibody test right now,
you would see it on the Internet.
I'm not seeing it yet. Don't confuse the
two tests and don't assume that oh I'm
negative on the antibody test that
immediate home test, so therefore I'm not
infectious and I don't have it. That's a
different question for a different time.
That's when we're starting to get out of
this. Right now we're going into it.
There's nothing like a community. We saw
that in the Louisville event. People got
together and started talking about how
they've had challenges and successes in
preventing their own heart attack, stroke,
or chronic disease. It became very clear
that you don't have to be a doc with a
full time 30-year career in preventive
medicine to understand this and
successfully prevent heart attack, stroke -
the number one killer and disablers of
people. You don't have to be a physician
to prevent eye disease, kidney disease.
All you have to do is think, listen, and
become part of the community. Now how do
you do that? Go to the membership login
on our web page, and as you can see, you
can get right in. You have you have to
sign up if you haven't signed up already.
And I've already signed up. I've already
gone in. It's very simple, very easy to
understand. In order to help encourage
this after the success and the positive
emotion the positive impact that we're
seeing with these events, we're saying,
look, we need to offer more of these
services for free in order to help grow
this community. So you'll see us starting
to do drawings for the webinar event, the
courses, we've got a book coming out in
about a month, we'll be offering that
even full-blown evaluations providing
those for free for folks that again
helped us grow the community. So if you'd
like to find out what the most recent
rules are for the most recent drawing,
just come to the membership page. Thank
you for your interest.
