Hello welcome everyone, I am Debabrata Maiti
from IIT Bombay.
I would like to welcome all of you for this
course organometallic chemistry I.
In this course we have decided to discuss
mainly about the synthetic aspects of organometallic
chemistry.
This will be both for in organic chemist and
organic chemist as well.
I am sure both of you have taken some courses
in organometallic chemistry so far, and you
have introduced, you have been introduced
to this topic before.
Now on the less there are some prerequisite
for this course which I will briefly outline,
but major aspects we will try to focus in
this, in our course is the fundamentals of
organometallic chemistry, what is the basis
of different reactions of organometallic chemistry.
Often we see both in, you know textbook or
in industry, number of reactions going on
and number of catalyst is going on.
And by looking at the transformation we just
simply get mesmerized how that reaction might
be possible okay.
So this is the beauty of organometallic chemistry
seemingly difficult reactions which is otherwise
not possible by let us say traditional organic
or inorganic type of reaction, organometallic
chemistry can do wonder.
So therefore, knowing different varieties
of organometallic reactions will be of fundamental
and as well as very synthetic importance.
As you know organometallic chemistry in often
term in often it is discussed in the way that
it is the metal, carbon bond formation reaction
or if a compound is having metal carbon bond
that is usually defined as the organometallic
compound or the chemistry derived from it
is classically defined as organometallic chemistry.
But there exist nowadays we do not really
restrict the term organometallic chemistry
to this basic definition, we also use various
non-metal or, you know semi-metal species
and their carbon complexes also under the
banner of organometallic chemistry.
And actually there are number of examples
with boron, silicon, phosphorous, arsenic
for example to discuss about their carbon
complexes as are these metal or non-metal
and or metal, semi-metal, carbon complexes
as the organometallic species.
So all actually derives from the fact that
the electronic negativity difference between
the that is a metal and the carbon centers.
Now without going into too much of the history
of organometallic chemistry and what organometallic
chemist has done so far we will try to focus
and we will be discussing about what organometallic
chemistry can do, what are the type of reactions
we are going to see okay.
So the prerequisite for this course, I would
like to point out that one should learn before
getting into the discussion of this course.
If we should know about the historical background
that is essential, since it is in our course
we will try to restrict on that and of course
different features of organometallic chemistry
features of organometallic chemistry these
are thing one is expected to know and you
know oxidation states fundamental To learning
to in learn in chemistry oxidation states
as well as period trend this is hopefully
all of your families are with.
and you can rephrase your memory with these
and of course d orbital’s electron count
and Hephtacity 
back bonding these are of course another famous
topic of organometallic chemistry and such
back bonding and knowing the properties and
knowing the properties of alken alkenes all
will be useful alken, alkenes all these things
one is expected to of course Phosphine are
all is going to be useful.
So for these are things I expect all of your
familiar with are you can phase your memory
little bit long will be about more about the
periodic table periodic trend and little bit
about the electronic configuration of each
and every metal that will be very important
because when we will be counting the electron
for a given complex those will be useful the
balance let in may lead like to you get an
idea about and of course the oxidation step
and periodic trend and different carbon monoxide
alkynes.
There electronic configuration and everything
once one is expected to know okay without
term speeding dual much on that I think I
will take you to the syllabus what we might
will be discussing for this course for this
course before getting into the syllabus they
exits a number of books and you know quite
a helpful for this organometallic chemistry
one is expected to learn of course my learning
as been influence by various furthers which
I have come across during my bachelors masters
PhD and post studying.
But a since they are number of books which
you are certainly encourage to read about
any books should be okay to so to speak in
terms of fundamental of the chemistry that
we will be discussing but mainly I would say
the basics of organometallic chemistry.
Basics of organometallic chemistry by a Anil
J. Elias it is our colleague at IIT Delhi
of course the other fundamental books include
Crabtree organometallic chemistry and Elschenbroich
as well as very I do not know excellent book
by John Hartwig these are the books one can
consult other than that any I think any other
book of organometallic chemistry can also
be consulted or you know I hope for if you
try to focus on this course and pick up any
other book that should be good enough for
this activity.
Now mainly we will try to outline the syllabus
of this course okay for this purpose we would
like to usually go one topic at a time on
a half an hour class bases so although it
is like a total ten course so definitely there
will divide into 20 class so 20 small, small
class each class roughly will discuss one
topic sometime it will spin over to another
class but most often in half an hour slot
you will try to discuss one topic sometime
two topics priory will discuss one topic into
the two half an hour courses if the topic
happen to be little bit of a more importance
and we need to discuss more about it, okay.
So let us look at the syllabus roughly.
While you will start as almost every you know
chemist need to discuss the 18 electron rules
briefly we will discuss that okay, 18 electron
rules and expecting you are familiar with
but you will just try to discuss electron
count of it and electron count of the organ
material complexes and try to give some example
and then move on from the top the major focus
from their won will be the ligand substitution
reaction, ligand substitution reactions, okay.
These are, are of two types one will be on
associative mechanism another will be the
dissociative one okay, this is the first topic
major topic we will be focusing regarding
the substitution reaction followed by you
know one of the most important topic will
be the oxidative addition with the plenty
of example all of them will be discussing
each of every topic with 20 of the example
oxidative addition.
These examples again are influenced by my
previous exposure or from different books
and so on, so these are going to be concerted
mechanism oxidative addition there are 3 different
mechanisms it will be so consorted SN 2 and
the radical mechanism these three different
mechanism will be discussed, of course almost
the microscopic green house of oxidative addition
will be the reductive elimination which is
again although it is microscopic reverse we
need to discuss quite efficiently on this
elimination, okay.
Moving on farther from this we will be discussing
the migratory aptitude, migratory insertion
and elimination reaction there would be a
and ß migratory insertion and elimination.
So the next topic will be the 
migratory insertion and elimination reaction
and elimination so here we will be discussing
a of course a migratory insertion, a migratory
elimination and of course ß migratory insertion,
ß migratory elimination and you know will
also discuss quite a lot about the example
of it and lot of examples where we will combine
both the ß migratory insertion and ß elimination
reactions.
Subsequently we will move to a abstraction
a abstraction and ß abstractions reactions
and finally moving for that four centre reactions
2 + 2 reactions these are various type of
reaction patterned are we will be discussing
and attack by external Ligand so when let
us say for example we have you know we have
an Olefin and then we would like to interact
to with this meta center show that is the
external ligand attack external ligand attack.
And then of course the reductive coupling
these are the topic mainly will be discussing.
Now of course some of these topic you may
have heard of we will try to discuss each
and every topic in greater detail once again
almost each of these topic will be discussed
in half in our time scale so roughly you know
1,2,3,4,5,6 and nearly 10 topics will be discussed
and each topic maybe having sub topics so
one topic will have nearly one hour of discussion
in some topic if you are having two sub topic
on the one topic we might will discuss half
an hour each of those, okay.
Of course after learning all these reaction
you know pattern or reactivity pattern we
then must apply some of these pattern some
of these reaction types to generalize reactions
scheme show to speak one of the catalytic
cycle.
Subsequently we would like to discuss let
us say mainly we will try to focus or we will
try to restrict ourselves to the hydrogenise
reaction and carbon lysine reaction and try
to see how some of these reaction types or
protocols can be applied to the catalytic
cycle.
Usually as you know a catalytic cycle will
have multiple steps, right so maybe having
let us say four steps, five steps and so on.
Now each of these four steps is necessarily
go forward by all these 10 topics or total
20 different subtopics we are talking about,
each of the catalytic cycle can be broken
down into these topics or subtopics, okay.
So therefore by knowing these topics we should
be able to discuss about any catalytic cycle
with confidence and we will be able to understand
the mechanism in details that is I guess will
be the strongest point of these organic metal
chemistry one.
So once again we will be discussing the ligand
substitution reaction to start with we will
have associative and dissociative mechanism
how the ligand substitution reaction occurs
at the beginning you have your organ metallic
components.
Of course the organ metallic component you
are going to have is going to be usually stable
1 you need to do some chemistry with it therefore
you need to undergo a ligand dissociation
or association reaction, right if it is an
eighteen electron spices for example you need
to loss one ligand to make it 16 electron
show that the metal fill encourage for an
heterogeneous substance otherwise 18 electron
species complex will not be really filling
that much encourage to undergo any reaction,
right.
So ligand substitution reaction how it occurs
associative mechanism and dissociative mechanism
will be discussing subsequently we will discuss
the oxidatie validation again this is one
of the topic which is quite popular oxidatie
validation usually remains as a bound like
you know insert some into the carbon bromine
bond of the bromobenzene for example by a
organic metallic species let us for example
platinum and then we get a platinum GL oxidation
state to platinum two place oxidation step
right and where we have a Arial carbon metal
bond allow with metal bromine bonds, right.
So these oxidatie addition reaction can be
of different type it could be contortioned
mechanism it could be SN2 mechanism of course
it can be of radical type in nature, right.
So that different types of oxidatie addition
we will discuss subsequently you would like
to see the reductive elements which is the
opposite of it, so imagine two partners are
on one metal and then we want to take out
those two partners and combine those two partner
together.
And then living a lot of vacancy side to the
metal center those will be again essential
for often regenerating the catalyst of making
the catalyst more effective okay.
As we go alone we will see how the migratory
incursion is occurring how you have one group
with the metal center and then that group
is trying to my great on the another group
such as all if in other unsaturated partner
which is associated with the metal center
now we can have various type of reaction form
that angle we can have alpha migratory incursion.
So at the alpha position of that Oliphant
or let us a carbonyl we will be migrating
another group which is associated with the
metal center then also we can have the you
know incursion or elimination and form the
ß position of the legated partner on the
metal center of course another variation of
such type of reaction will be the abstraction
this abstraction could be you know similar
in a way it is essentially going to be similar
compare to your migratory incursion or elimination
reaction.
So alpha extracts and the beta abstracts in
the you will be similar to the you know alpha
migratory elimination or beta migratory elimination
but fundamentally this are different type
of reaction that you will see the difference
in lot of cases we may not be having an opportunity
to let say undergo traditional oscillate word
or traditional reductive elimination re access.
So what will then have that particular case
is we might will haven opportunity to go about
the four center reaction mechanism right.
So that is also essential when we need that
what are the major type of reaction and when
we cannot have those major type of reaction
pattern alternative has to be looked up.
similarly like alpha and beta migratory incursion
elimination when we talk about those at the
major one but when the abstracts and reaction
dominant that also need to be looked at, others
will be of course the 2+2 reactions where
you know 2 unsaturated unit will be coupling
together.
So curve you know fray famous you know reactions
ewe have seen that might a three sees reactions
how the reactions occurred what is the basic
fundamental outline principle for this reaction
would like to also discuss.
Then you know simple if you take let us a
simple all if new on to a react it with a
nuclei file you may not be getting such any
reaction but that all if in if you want to
interact with the metal center then you might
will have an opportunity to react the nuclear
file with the all if in this is another class
of reaction you know external attack by nuclei
file to the olefin center.
Sub sequent of course we would also like to
discuss the detective coupling which is again
another fundamental class of reactions so
these at the major type of reaction will be
discussing in depth in detail regarding this
course after discussing this we will be discussing
the hydrogenous reactions, and a carbonilious
reaction, in terms of hydrogenous and catalyst
we have two types of catalysts, one is mono
hydride catalysts, and the other will be the
de-hydride catalysis, how fundamentally these
two catalyst are different?
What are the steps to undergo the hydro no
2, under to understand the hydrogenous reactions
that will be trying to discuss.
Mainly you will see usually it’s a elegant
association, and disassociation reaction then
of course oxidity addition, or olefin co-ordinance
and sub sequent oxidity addition in suction
and then derive illumination reaction, to
view the product that these are going to be
the simplest reaction of all, finally we will
move on for this course the carbonation where
we would like to look at quite lot of topics.
Such as hydro formulation reaction of course
monsoon to acetic acid, process where will
be discussing about the methanol getting converted
in to the carboxylic acid, and in hydro formulisation
reaction we will be discussing olefin reacting
with the carbon monoxide, and hydrogen mix
are to be viewed, al-de Hyde this al de hide
can be of two different type, it could be
the terminal al de hide, it could be the branch
one as well, and subsequently we will be discussing
the hydro carbonisation reaction.
And we will cap of the discussion why having
the hydro nation reaction, and hydro nation
of olefin, we also like to touch up on little
bit, just little bit on the asymmetric version
of this reactions.
Okay we may not be able to discuss to the
infests of time, wait for much about asymmetric
reaction but whenever possible, whenever an
asymmetric version of a catalysts’ will
be possible we will be discussing in briefly.
So that will be also discussed in this fundamental
type of reaction, look oxidative values and
reductive luminous and you know the type of
reactions whenever there is a scope of a discussing
the asymmetric catalysis or asymmetric accented
how fundamentally it will be tell to it by
a reaction type, also be a discussed during
this course, okay.
So we will come again so we will total again
including this one we will have total ten
hours discussion, and I would like you to
ask as many question as possible, of each
and every section and of course there will
be some evolution as want to expect for this
courses, allow with it we will try to see
if your understanding can be border, if you
have any quarries please feel free to ask
me, okay.
So in the next class, mainly we will try to
discuss the eighteen lection rule, and from
there on various elegance substation we will
focus on them, okay so this will be all for
the introductive part of this course and you
know, feel free to drop me any quarries that
you may be having regarding course, thank
you.
