- If you get COVID-19
and you recover from it,
does that mean you're immune to the virus?
And even if you were to become immune,
how long would that immunity last?
Now we're still waiting on studies
to really give us definitive
answers to these questions.
But in the meantime I
think what can help us
understand COVID-19 immunity,
is thinking about our body's
responses to other infections
and I kind of think of it
as an immunity spectrum.
So what I wanna do now,
is talk us through some examples
along that immunity spectrum
to help us better understand
where COVID-19 might fit in.
[upbeat music]
On one end of the spectrum
is Varicella-zoster virus,
the virus that causes Chickenpox.
And you might remember
from your own childhood,
that if you get Chickenpox once
you usually develop a
lifelong immunity to it
and you don't get it again.
This kind of lifelong immunity
happens because of antibodies.
Something you've probably been
hearing loads about recently.
Antibodies are proteins
made by our immune system
that protect us from harmful things.
Those can be infections
like viruses and bacteria,
but also toxins and cancer cells.
With Chickenpox,
your body churns out antibodies
that are in it for the long haul.
And it also has cells
that are ready to make more antibodies.
Should you meet the virus again,
you can get exposed to viruses
through natural infection
or this is a preferable
way, you get immunized.
Meaning you get a vaccine
that introduces your body
to a weakened version or
a dead version of a virus,
so that your body knows what to recognize
and it mounts a solid immune response
that stops you getting sick.
And if you didn't get sick
with Chickenpox as a kid,
you get two shots of the vaccine
that gives you longterm immunity.
Now, some people who have
a weakened immune system
can get Chickenpox a second time,
and in fact,
our bodies are never able to
get rid of the virus totally.
It stays latent inside our nerve cells
and in around one third of people,
the virus reactivates later
in life and causes Shingles.
So how does COVID-19
compare to this example,
obviously the ideal situation would be
that you get COVID-19 once and that's it.
You're immune forever to the
virus that causes the disease.
Unfortunately, this
doesn't seem that likely.
And here's why.
There were early studies showing
that when people recover from COVID-19
they do have antibodies in their system,
but because this is such a new infection.
One, we're not sure how
long those antibodies
hang around for and two,
there are some reports
of those antibody levels
dropping really low, just a
few weeks after infection.
[upbeat music]
Here's another example, Whooping cough,
this is caused by a bacteria,
and usually if you get infected once
that immunity lasts from 4 to 20 years.
So quite a big range.
Because immunity fades over time.
The CDC recommends you get vaccinated
against Whooping cough,
but even with that,
you need to get booster shots.
Those are shots that you get
your initial vaccinations
to make sure you stay protected
over a period of time.
So even if we do develop a
successful vaccine for COVID-19,
maybe that vaccination
scenario will be similar to
Whooping cough where you get
your initial doses of vaccine,
but then you have to get
booster shots as well.
[upbeat music]
So here's our next example.
H1N1 Influenza, also known as Swine Flu.
Studies have shown that immunity to H1N1
can last anywhere from
2 years to 10 years.
This is a strain of flu that
caused a pandemic in 2009
but now circulates pretty regularly
alongside other common flu strains.
And with the flu the
reason that we're getting
new flu shots every single flu season,
is because flu strains are changing.
And so literally every summer
in the Northern hemisphere,
scientists are racing to predict
which flu strains are gonna hit us.
And what kind of vaccine they need to make
for that specific flu season.
Some experts predict that SARS-COV-2
will follow that same path as H1N1.
Meaning it causes a
terrible pandemic at first
but then circulates much
more like a regular virus
after the fact.
[upbeat music]
Now when it comes to figuring
out where the new Coronavirus
might fit on the immunity spectrum.
I think our best bet
might be to compare it to the
original SARS Coronavirus.
SARS stands for Severe
Acute Respiratory Syndrome,
and that's caused by the
Coronavirus that emerged in 2002
and caused a pandemic in 2003.
Infecting more than 8000
people around the world.
Studies of SARS patients who recovered,
showed their antibody levels
peaked around 2 to 4 months
and that they offered
protection for 2 to 3 years.
So is this a timeline
that we might consider
for SARS-COV-2.
Well, there are some studies that show
that when our bodies are
infected with SARS-COV-2,
we produce what we call a
neutralizing antibodies.
And these can stick around
and offer protection
for a couple of weeks.
That's what the early studies are showing.
But clearly a couple
of weeks is a ways off
from two to three years.
I think the glimmer of hope might be
that there's so much genetic
similarity between SARS-COV-2,
and SARS-COV-1.
[upbeat music]
Another good comparison we have right now
is to the four Coronaviruses
that caused the cold
immunity to these seasonal Coronaviruses
starts fading just after a
few months and within a year.
Most people are vulnerable to reinfection,
meaning it won't go away.
It will still infect people,
but it won't cause such serious disease
and it won't cause so many infections.
So that's a possible
scenario that we might see
with the new Coronavirus.
[upbeat music]
So on the other end of
the immunity spectrum
compared to where we started is HIV.
People with HIV do develop
antibodies to the virus,
but either those antibodies
don't stick around for long,
or the virus has really cunning ways
to hide from the antibodies.
That's partly because HIV
is constantly mutating
every time it's
replicating inside the body
that makes the virus a moving
target for our immune system.
Some good news on the COVID-19 front,
is that this Coronavirus
does not seem to mutate
anywhere near as
frequently as HIV mutates.
That means it stays a much more consistent
and it means we have far
less of a moving target.
And because of that,
some experts are saying that reinfection
with the new Coronavirus
could be less likely
just because the virus
isn't changing so much.
So our immune systems recognize
it and know how to fight it.
But I still think it's way too early
to be saying that reinfection is unlikely
just because of how new this virus is
and how much we're learning day to day.
So we don't know exactly where COVID-19
is gonna fit along this immunity spectrum.
But let's say you get
infected with the virus
and it does give you antibodies
that hang around for months,
maybe even a year or so.
In that scenario,
you can start thinking about herd immunity
as one way out of the pandemic.
Herd immunity is when a
significant proportion
of the population has
become immune to a disease.
Either through becoming
infected or being vaccinated,
and when herd immunity is achieved,
it stops a disease spreading like wildfire
through a population.
That exact proportion of
people that need to be immune
to a disease in order to
achieve herd immunity.
It varies from pathogen to pathogen
and it depends on how
infectious a microbe is.
We're still a ways off from
thinking about herd immunity
as our way out of the COVID-19 pandemic
for at least two reasons.
The first being that
we just don't know yet
how long those antibodies
will hang around for
and how protective they'll be.
But second, because for
herd immunity for COVID-19,
you'd need between 50%
to 70% of a population
to become immune.
And we don't have a vaccine yet,
meaning we'd have to see a
lot of people just get sick
from the virus and that's not
a feasible way out of the pandemic.
And finally, there's that
question about antibody testing.
I think if we get studies that show us
how protective antibodies
are to this virus
and how long those
antibodies stick around.
Then in that case,
widespread antibody testing
could be really useful,
especially if it's a quick
fingerprint blood test
to help us understand who is immune,
for whom is it safe to go back to work
and how quickly could we start
resuming normal activities?
But even if a large number
of people have been infected,
recovered, and have immunity,
it's still not gonna trigger
a sudden reopening of society.
There's gonna have to be
a gradual peeling back
of containment measures
like sheltering in place
to make sure that we're
constantly guarding
against a second wave and
against future outbreaks.
And that's gonna be our reality
until we have a vaccine.
Thanks so much for watching.
Drop your questions here
in the comments below
or reach out to me on social media.
