Hello, everyone. Nice to meet you. There are times when your body suddenly hardens, right?
This time, we're going to talk about cancer and DNA.
When your body is hardened like this, you're going to do
only 3 movements of stretching on the neck, shoulders, and back.
Actually, it's been more than 10 years since I ran a marathon.
By the way, before I exercise,
I must do some of the stretching that I do.
First of all, put your fingers on both hands and head back.
Then bend your elbows and naturally pull your fingers like this.
Then, 1, 2, 3, 4, 5. Like this.
By the way, it helps to stretch if you pull it hard.
Next is the second one.
Second, the elbow of the left arm is drawn by walking with the right hand.
Do this and count to one, two, three, four, five.
Then, now change the order,
put your right elbow with your left arm and pull it like this.
And then count to one, two, three, four, five.
Then, the shoulders have been loosened to some extent.
Now, there is a way to make it easier by turning the shoulders.
Put your shoulders back like this.
And then you go back and down, forward, up, and do this motion one after another.
Do this one after another, and return this five times.
Then it would be nice if you did the opposite.
So you put your shoulders back and down earlier, right?
This time, you turn it up, forward, and down like this. 
It was the opposite direction earlier, right?
If you turn it like this, you'll feel like your shoulder muscles are loosening up a little.
How do you feel? Are you feeling better?
Stretching like this to relieve tension
will increase your immersion in the video
and help you focus.
This time, I think you can get an idea about
how to use DNA for cancer treatment, and if you watch this video until the end.
Shall we take a look?
In our body, every cell contains DNA,
and DNA contains genes.
The tissue to which each cell belongs, i.e. skin, internal organs, bones, etc.,
the appropriate genes selectively work,
and proteins are synthesized from them to create the desired tissues and organs.
Here's a picture.
If you look at this picture, this DNA looks like this, because of the ultraviolet light.
It shows DNA being destroyed by ultraviolet light.
DNA is a relatively stable double-helix structure,
but you can see this form for what is called a double-helix structure, right?
Of course, on the left, before the destruction was caused by ultraviolet light,
Before the damage occurs, on the right side, after the damage, there is a difference.
The basic skeleton structure is the same.
Now, so this picture shows that DNA is damaged by UV rays,
and DNA errors include DNA damage and DNA mutations.
DNA damage is a result of the DNA having an abnormal chemical structure, 
and mutations are a change in the order of standard base pairs.
DNA damage can be repaired to a large extent by repair and repair systems.
Unrepaired DNA damage can accumulate in cells
and cause aging, and these changes can alter gene function,
gene expression conditions, and lead to cancer.
Mutation is when the DNA molecule on which the genetic information is recorded
differs from the original by a number of factors.
Mutations are inherited, but damaged DNA is not inherited.
There are many cases where DNA is damaged and leads to cancer,
so it is good to know how DNA damage occurs.
Some of the factors that cause DNA damage
include ultraviolet rays,
and radiation such as X-rays,
alpha rays, beta rays, and gamma rays.
These are included all these things.
And cigarette smoke, this is one of the factors
that damage DNA as well as radiation.
Reactive oxygen species occur naturally, 
but too much of these are a problem.
So, antioxidants are important.
And then you think of genetic toxicity, so-called carcinogens.
Genetic toxic chemicals.
By the way, leaving damaged DNA can lead to mutations and disease,
so the repair system works.
Individual cells can undergo up to 1 million DBA changes a day.
The cells whose DNA recovery path is interrupted accumulate DNA damage.
As cancer progresses, tumors accumulate more mutations in DNA recovery proteins.
The genome and mitochondrial DNA are constantly 
under threat of damaging exposure to chemical, physical and genotoxic substances.
When the DNA repair system is not working effectively,
DNA lesions, mutations, and carcinogenic modifications occur.
100,000 mutations per cell are the driving force behind the tumor.
The figure shows an example of a DNA recovery system working.
Now, if you look at the picture here, this is normal DNA.
This is an example of a DNA damaged by some factor,
and the repair system starts 
working on the damaged part 
and proceeds in this way.
There are many examples of recovery working, just as damage varies.
However, cancer cells must have a DNA damage and repair system to survive.
Some anticancer drugs are said to be fatal to cancer 
by interfering with the DNA repair of cancer cells.
These are published May 19, 2019
in Science Translational Medicine.
Oh, in the picture here, the title from the homepage of
Science Translational Medicine is taken like this.
There is an anti-cancer drug called Cediranib.
However, research shows that this is effective
when used in combination with other drugs, but it is still clinically insufficient.
Originally, cediranib was developed
to inhibit the formation of blood vessels that tumors need to grow.
Cancer cells grow at a rapid rate,
but rapid replication can also damage the cell's genetic structure.
Too much damage interferes with cell function,
so cancer cells must repair themselves regularly.
For cancer cells, DNA recovery is a double-edged sword.
Cancer cells continue to grow and can mutate.
In some ways, fast-growing cancer cells 
made themselves more vulnerable.
These studies were done by Yale University in the United States.
I think cancer cells are just cells that are no different from normal cells.
If normal cells are damaged, cancer cells can't do much.
It's going to be a situation where cancer cells are bound to be damaged.
So, I realized that cancer is not a monster anymore.
In fact, I've been afraid of cancer.
Now, then we now understand the nature of cancer, 
and then I think it's worth fighting against cancer.
This is the end of this video. Thank you for watching until the end. 
If you like this video, please let me know.
I'm sure you'll subscribe, like, and set notifications.
In the next video, I hope to see you all
in a healthier and happier appearance. Everyone, good job.
Good-bye. That's it for now.
