Time magazine has called it the most horrible drug in the world, and last month, we got to have some of it here
in the U.S.
Meanwhile, scientists have a shiny new method for understanding how other street drugs affect
the human body.
I'm Hank Green, and this is your brain on SciShow News.
In September, a poison control center in Phoenix, Arizona reported the first two medical emergencies in
the US to be caused by the drug known as "Krokodil", a ferociously toxic opiate made by cooking codeine
pain medicine with ridiculous stuff like gasoline, paint thinner, or alcohol.
After being injected, the drug crosses the blood-brain barrier, where it binds to opiate receptors and causes a
brief high described as being similar to that of heroin.
And just like with heroin, the user quickly builds a dependence that's difficult and painful to break, but
krokodil is so corrosive that in addition to messing up your mind, it dissolves bones, brain tissues, and veins.
And it can cause gangrene, often leading to amputations.
Users are known to quickly develop scaly, gangrenous skin, giving the drug its name.
This stuff is so toxic that in Russia, where it's been used since about 2003, it's reported that the average life
expectancy of a krokodil user is two or three years.
So, what is it?
Desomorphine, the active ingredient krokodil, is made by dissolving codeine in powerful solvents, and then
running it through a bunch of a simple but dangerous reactions to create codeine salts that quickly dissolve in
body tissues.
Desomorphine was actually patented in the US in 1932 and marketed for a while as a sedative and pain reliever.
But without the pharmaceutical grade chemicals necessary to make the old drug, street cooks have been
content to use most easily available substitutes, no matter how stupid or dangerous.
The result is a substance that's chemically very similar to heroin, but with traces of stuff like paint thinner,
iodine, or gasoline thrown in, making it much more dangerous than even the stuff that was off the market in
the first place.
In this case, krokodil is a lot like another drug that's gained popularity in the last decade: designer
cannabinoids.
Sold under names like "Spice" and "K2", it's reported to be the second most popular drug in the US and Europe,
used by one in nine high school students in the US.
And while its marketed as a bunch of herbs that imitate the effects of marijuana, it's actually just a bunch of
synthetic, untested chemicals with names like JWH-018 and AM-2201 that have been sprayed onto dried leaves.
The leaves are just for flair; the synthetic chemicals bind to cannabinoid receptors in the brain and create a high
similar to that of THC, except with way nastier side effects like psychosis, seizures, severe kidney damage,
and heart attacks.
As more and more teens been hospitalized in the last few years after using the drug, chemists have begun to
wonder: how exactly does it affect the body?
Attempting to answer that question, a group of chemists from the University of Arkansas analyzed the urine of
fifteen subjects who had recently taken the drug.
By carefully separating the compounds in the users' pee, they identified what materials the drug had broken down
into, called metabolites, and the proportions of those metabolites.
Interestingly, the results varied to a huge degree among users, unlike with THC.
So while what exactly these compounds are and how they work are still unknown, the new research may have
at least developed a way to detect them as users keep showing up in hospital emergency rooms.
But until there are more answers, there's at least some useful input from an authoritative source about the use
of spice.
Doctor John Huffman is a chemist at Clemson University whose research on marijuana's effects in the
eighties and nineties led to the development of these knock-off cannabinoids.
And he told The Associated Press in 2010, and I quote, "People who use it are idiots". This is Hank Green in the
Keith Chim Studio, thanking all of our SciShow viewers, especially our Subbable supporters, for continuing to
support SciShow.
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