 
Abacavir 8mg/kg (adult 300mg) 12H oral.

### Abacavir + lamivudine 600mg/300mg tab, >12yr (NOT/kg): 1tab

### daily oral.

### Abacavir + lamivudine + zidovudine 300mg/150mg/300mg tab,

### >18yr (NOT/kg): 1tab 12H oral.

### Abarelix Adult (NOT/kg): 1 vial (delivers 100mg) IM on day 1, 15

### and 29, and then every 28 days.

### Abatacept NOT/kg: 500mg (40-60kg) 750mg (60-100 kg) 1g

### (>100kg) IV over 30min day 1, 2wk, 4wk, then every 4wk.

### Abciximab 0.25mg/kg IV stat 10min before angioplasty, then

### 0.2mcg/kg/min (max 10mcg/min) IV for 12hr. .

### Acamprosate calcium Adult (NOT/kg). <60kg: 666mg mane, 333mg

### noon and nocte oral. >60kg: 666mg 8H.

### Acarbose 1-4mg/kg (adult 50-200mg) 8H oral.

### Acebutolol 4-8mg/kg (adult 200-400mg) 8-24H oral.

### Aceclofenac 2mg/kg (adult 100mg) 12H oral.

### Acemetacin 1.2mg/kg (adult 60mg) 8-12H oral.

### Acenocoumarol See nicoumalone.

### Acetaminophen See paracetamol.

### Acetazolamide 5-10mg/kg (adult 100-250mg) 6-8H (daily for

### epilepsy) oral.

### Acetohydroxamic acid 5mg/kg (adult 250mg) 6-8H oral.

### Acetylcholine chloride Adult (NOT/kg): 1% instil 0.5-2ml into

### anterior chamber of the eye.

### Acetylcysteine Paracetamol poisoning (regardless of delay):

### 150mg/kg in 5%D IV over 1hr; then 10mg/kg/hr for 20hr (delay

### <10hr), 32hr (delay 10-16hr), 72hr (delay >16hr) and longer if still

### encephalopathic; oral 140mg/kg stat, then 70 mg/kg 4H for 72hr.

### Monitor serum K+

### Acetylsalicylic acid See aspirin.

### Acetyl sulfisoxazole 1.16g = 1.0g sulphafurazole (qv).

### Aciclovir Neonate-12wk: 20mg/kg IV over 1hr daily (<30wk gest),

### 18H (30-32wk), 12H (1st wk life), 8H (2-12wk) for 2wk (3wk and

### CSF PCR -ve if herp enceph). >12wk: EBV, herpes enceph,

### immunodef, varicella: 500mg/m2 (12wk-12 yr) 10mg/kg (>12yr) 8H

### IV over 1hr. Cutane

### Acipimox 5mg/kg (adult 250mg) 8-12H oral.

### Acitretin 0.5-1mg/kg (adult 25-50mg) daily oral.

### Acriflavine hydrochloride 0.1% soltn: apply 12-24H.

### Acrivastine 0.15mg/kg (adult 8mg) 8H oral.

### Actinomycin D See dactinomycin.

### Activated charcoal See charcoal, activated.

### Acyclovir See aciclovir.

### Adalimumab Adult (NOT/kg): 40mg every 1-2wk SC.

### Adapalene 0.1% gel: apply once a day before bedtime.

### Adefovir Adult (NOT/kg): 10mg daily oral.

### Adenosine Arrhythmia: 0.1mg/kg (adult 3mg) stat by rapid IV

### push, incr by 0.1mg/kg (adult 3mg) every 2min to max 0.5 mg/kg

### (adult 18mg). Pul hypertension: 50mcg/kg/min (3 mg/ml at

### 1ml/kg/hr) into central vein.

### Adrenaline Croup: 1% 0.05 ml/kg diluted to 4ml, or 1/1000

### 0.5ml/kg (max 6ml) by inhaltn. Cardiac arrest (repeat if reqd):

### 0.1ml/kg of 1/10,000 IV or intracardiac; via ETT 0.1 ml/kg of 1/1000.

### Anaphylaxis: IV 0.05-0.1ml/kg of 1/10,000, repeat if reqd; IM into

### thigh:

### Adrenocorticotrophic hormone (ACTH) See corticotrophin.

### Agalsidase beta 0.2-1mg/kg every 2wk IV over 40min.

### Agar + paraffin 65% NOT/kg: 6mo-2yr 5ml, 3-5yr 5-10ml, >5yr

### 10ml 8-24H oral.

### Agar + paraffin + phenolphthalein (Agarol) NOT/kg: 6mo-2yr

### 2.5ml, 3-5yr 2.5-5ml, >5yr 5ml 8-24H oral.

### Alatrofloxacin 4mg/kg (adult 200mg) daily IV over 60min.

### Severe inftn: 6mg/kg (adult 300mg) daily IV over 90min.

### Albendazole Pinworm, threadworm, roundworm, hookworm,

### whipworm: 20mg/kg (adult 400mg) oral once (may repeat after

### 2wk). Strongyloides, cutaneous larva migrans, Taenia, H.nana,

### O.viverrini, C.sinesis: 20mg/kg (adult 400mg) daily for 3 days,

### repeated in 3wk. 7.5mg/kg (

### Alcohol See chlorhexidine.

### Albumin 20%: 2-5ml/kg IV. 4%: 10-20ml/kg. If no loss from plasma:

### dose (ml/kg) = 5 x (increase g/L) / (% albumin).

### Albuterol See salbutamol.

### Alclometasone 0.05% cream or ointment: apply 8-12H.

### Aldesleukin (synthetic IL-2) Malignancy: constant IV infsn less

### toxic than bolus injtn: 3,000,000-5,000,000u/m2/day for 5 days, if

### tolerated repeat x1-2 with 5 day interval.

### Alefacept Adult (NOT/kg): 7.5mg IV, 15mg IM wkly 12wk.

### Alemtuzumab Adult (NOT/kg): 3mg daily IV over 2hr for 2-3

### days, 10mg daily 2-3 days, then 30mg x3/wk for up to 12wk.

### Alendronate 0.5mg/kg (adult 40mg) daily oral. Postmenopausal

### osteoporosis (adult, NOT/kg): 10mg daily, or 70mg slow-release

### wkly.

### Alendronate 70mg + vitamin D3 2800u 1 tab each wk oral.

### Alfacalcidol 0.05mcg/kg (max 1mcg) daily oral or IV, adjusted

### according to response.

### Alfentanil 10mcg/kg IV or IM stat, then 5mcg/kg prn. Theatre

### (ventilated): 30-50mcg/kg IV over 5min, then 15mcg/kg prn or 0.5-

### 1mcg/kg/min. ICU: 50-100mcg/kg IV over 10min, then 0.5-

### 4mcg/kg/min.

### Alfuzosin Adult (NOT/kg): 10mg daily oral.

### Alginic acid (Gaviscon single strength) <1yr: liquid 2ml with feed

### 4H. 1-12yr: liquid 5-10ml, or 1 tab after meals. >12yr: liquid 10-

### 20ml, or 1-2 tab after meals.

### Alglucerase Usual initial dose is 60u/kg every 2wk IV over 2hr,

### adjusted according to response; reduce every 3-6mo.

### Alimemazine See trimeprazine.

### Aliskiren Adult (NOT/kg): 150mg (max 300mg) daily oal.

### Alitretinoin 0.1% gel: apply 6-12H.

### Allopurinol 10mg/kg (adult 300mg) 12-24H oral. Chemotherapy:

### 50-100mg/m2 6H IV, oral.

### Almotriptan Adult (NOT/kg): 6.25-12.5mg oral, repeat in 2hr if

### reqd (max 2 doses in 24hr).

### Alosetron Adult (NOT/kg): 1mg daily oral, incr if reqd after 4wk

### to 1mg 12H (stop if no response after 4wk).

### Alpha1 proteinase inhibitor See alpha1 antitrypsin.

### Alpha1 antitrypsin 60mg/kg once wkly IV over 30min.

### Alpha tocopheryl acetate One alpha-tocopheryl (at) equivalent =

### 1mg d-at = 1.1mg d-at acetate = 1.5mg dl-at acetate = 1.5u vit E.

### Abetalipoproteinaemia: 100mg/kg (max 4g) daily oral. Cystic

### fibrosis: 45-200mg (NOT/kg) daily oral. Newborn (high dose,

### toxicity reported): 10-25mg/kg

### Alprazolam 0.005-0.02mg/kg (adult 0.25-1mg) 8H oral. Slow rel:

### 0.5-1mg daily, incr to 3-6mg (max 10mg) daily oral.

### Alprenolol 1-4mg/kg (max 200mg) 6-12H oral.

### Alprostadil (prostaglandin E1, PGE1) Maintain PDA: 60 mcg/kg

### in 50ml 0.9% saline 0.5-3ml/hr (10-60ng/kg/min). Erectile

### dysfunction (adult NOT/kg): 2.5mcg intracavernous inj, incr by

### 2.5mcg if reqd to max 60mcg (max 3 doses/wk).

### Alteplase (tissue plasminogen activator) 0.1-0.6mg/kg/hr IV for 6-

### 12hr (longer if no response); keep fibrinogen >100mg/dL (give

### cryoprecipitate 1bag/5kg), give heparin 10u/kg/hr IV, give fresh

### frozen plasma (FFP) 10ml/kg IV daily in infants. Local IA infsn:

### 0.05mg/kg/hr, give FFP 10ml/kg IV dail

### Altretamine 150-300mg/m2 daily oral.

### Aluminium acetate 13% soltn (Burrow's lotion): for wet

### compresses, or daily to molluscum contagiosum.

### Aluminium chloride hexahydrate 20% lotion: x1-2/wk.

### Aluminium hydroxide 25mg/kg (adult 0.5-1g) 4-6H oral. Gel

### (64mg/ml) 0.1ml/kg 6H oral.

### Aluminium hydroxide 40mg/ml, Mg hydroxide 40mg/ml, simethicone

### 4mg/ml (Mylanta, Gelusil) 0.5-1ml/kg (adult 10-20ml) 6-8H oral.

### ICU: 0.5ml/kg 3H oral if gastric pH <5.

### Aluminium sulphate 20% soltn: apply promptly to sting.

### Alverine 1-2mg/kg (adult 60-120mg) 8-12H oral.

### Amantadine hydrochloride 2mg/kg (adult 100mg) 12-24H oral. Flu

### A prophylaxis (NOT/kg): 100mg daily (5-9yr), 100mg 12H (>9yr).

### Ambrisentan Adult (NOT/kg): 5mg (max 10mg) daily oral.

### Amcinonide 0.1% lotion, cream, ointment: apply 8-12H.

### Amethocaine Gel 4% in methylcellulose (RCH AnGel): 0.5g to skin,

### apply occlusive dressing, wait 30-60min, remove gel. 0.5%, 1%: 1

### drop/eye.

### Amifostine 910mg/m2 IV over 15min daily 30min before

### chemotherapy; reduce to 740mg/m2 if severe side effects.

### Amikacin Single daily dose IV or IM. Neonate: 15mg/kg stat,

### then 7.5mg/kg (<30wk) 10mg/kg (30-35wk) 15mg/kg (term <1wk)

### daily. 1wk-10yr: 25mg/kg day 1, then 18mg/kg daily. >10yr:

### 20mg/kg day 1, then 15mg/kg (max 1.5g) daily. Trough level

### <5.0mg/L.

### Amiloride 0.2mg/kg (adult 5mg) 12-24H oral.

### Aminoacridine hydrochloride See aminacrine.

### Aminacrine hydrochloride 0.02% 1 drop/eye 2-4H.

### Aminobenzoic acid 60mg/kg (max 3g) 6H oral.

### Aminocaproic acid 3g/m2 (adult 5g) over 1hr IV, then 1g/m2/hr

### (adult 1-1.25g/hr). Prophylax: 70mg/kg 6H IV, oral.

### Aminoglutethimide Adult (NOT/kg): 250mg daily oral, incr over

### 4wk to 250mg 6H.

### Aminohippuric acid (PAHA) 6-10mg/kg stat, then 0.2-0.5

### mg/kg/min IV gives 2mg/100ml in plasma.

### Aminolevulinic acid 20% soltn: apply to lesions, expose to 400-

### 450nm blue light for 1000sec (10 J/cm2) next day; repeat after 8wk

### if reqd.

### Aminophylline (100mg = 80mg theophylline) Load: 10 mg/kg (max

### 500mg) IV over 1hr. Maintenance: 1st wk life 2.5mg/kg IV over 1hr

### 12H; 2nd wk life 3mg/kg 12H; 3wk-12 mo ((0.12 x age in wk) + 3)

### mg/kg 8H; >12mo and <35kg, 55 mg/kg in 50ml 5%dex-hep at

### 1ml/hr (1.1mg/kg/hr) or 6mg/kg IV over 1hr 6H; >

### Aminosalicylic acid (4-Aminosalicylic acid, ASA, 4-ASA, para-ASA,

### PAS) 50-100mg/kg (adult 4g) 8H oral.

### 5-Aminosalicylic acid See mesalazine.

### Amiodarone IV: 15mg/kg in 50ml 5%dex (no heparin) at 5ml/hr

### (25mcg/kg/min) for 4hr, then 1-3ml/hr (5-15mcg/kg /min, max

### 1.2g/24hr). Oral: 4mg/kg (adult 200mg) 8H 1 wk, 12H 1 wk, then

### 12-24H. After starting tablets, taper IV infsn over 5 days. Reduce

### dose of digoxin

### Amisulpride 1-6mg/kg (adult 50-300mg) daily oral; acute

### psychosis 5-15mg/kg (adult 300-800mg) 12H.

### Amitriptyline Usually 0.5-1mg/kg (adult 25-50mg) 8H oral.

### Enuresis: 1-1.5mg/kg nocte.

### Amlodipine 0.05-0.2mg/kg (adult 2.5-10mg) daily oral.

### Amlodipine + olmesartan (5mg/20mg, 5/40, 10/20, 10/40) Adult

### (NOT/kg): 1 tablet daily oral.

### Amlodipine + valsartan (5mg/160mg, 5/320, 10/160, 10/320)

### Adult (NOT/kg): 1 tablet daily oral.

### Amobarbital See amylobarbitone.

### Amodiaquine Treatment: 10mg/kg daily for 3 days oral. Prophylaxis:

### 5mg/kg once a wk.

### Amorolfine Nail lacquer 5%: apply x1-2/wk.

### Amoxapine 0.5-2mg/kg (adult 25-100mg) 8H oral. .

### Amoxicillin See amoxycillin.

### Amoxycillin 10-25mg/kg (adult 0.25-1g) 8H IV, IM or oral; or

### 20mg/kg 12H oral. Severe inftn: 50mg/kg (adult 2g) IV 12H (1st wk

### life), 6H (2-4 wk), 4-6H or constant infsn (4+ wk). .

### Amoxycillin + clavulanic acid Dose as amoxycillin. 4:1 (non-Duo

### products) 8H, 7:1 (Duo) 12H, 16:1 (XR) 12H oral.

### Amphetamine See dexamphetamine.

### Amphotericin B (Fungizone) Usually 1.5mg/kg/day (up to

### 2mg/kg/day) by continuous infsn IV. Central line: 1.5mg/kg in 50ml

### 5%dex-hep at 2ml/hr (up to 46kg); 1.5 mg/kg in 1.2 ml/kg 5%dexhep

### (1.25mg/ml) at 0.05ml/kg/hr (over 46kg). Peripheral IV: usually

### 1.5mg/kg in 12ml/kg 5% dex-he

### Amphotericin, colloidal dispersion (Amphocil, Amphotec) Usually

### 3-4mg/kg (up to 6mg/kg for aspergillus) daily IV at 2.5mg/kg/hr.

### Amphotericin, lipid complex (Abelcet) 2.5-5mg/kg daily over 2hr

### IV, typically for 2-4wk.

### Amphotericin, liposomal (AmBisome) 3-6mg/kg (up to 15 mg/kg

### if severe inftn) daily over 1-2hr IV, typically for 2-4wk.

### Ampicillin 10-25mg/kg (adult 0.25-1g) 6H IV, IM or oral. Severe

### inftn: 50mg/kg (max 2g) IV 12H (1st wk life), 6H (2-4 wk), 3-6H or

### constant infsn (4+ wk).

### Ampicillin + flucloxacillin NOT/kg. 125mg/125mg or 250/ 250

### (child), 250/250 or 500/500 (adult) 6H oral, IM or IV.

### Ampicillin 1g + sulbactam 0.5g 25-50mg/kg (adult 1-2g) of

### ampicillin 6H IM or IV over 30min.

### Amprenavir Age 4yr or more. Soltn (max 2.8g/day): 22.5 mg/kg

### 12H, or 17mg/kg 8H oral. Caps (max 2.4g/day): 20mg/kg 12H, or

### 15mg/kg 8H oral.

### Amrinone <4wk old: 4mg/kg IV over 1hr, then 3-5mcg/kg /min.

### >4wk: 1-3mg/kg IV over 1hr, then 5-15mcg/kg/min.

### Amsacrine 450-600mg/m2 IV over 2hr daily for 3-5days.

### Amylase See pancreatic enzymes.

### Amylobarbitone 0.3-1mg/kg (adult 15-50mg) 8-12H, or 2-4mg/kg

### (adult 200-400mg) at night, oral.

### Anagrelide Adult (NOT/kg): 0.5mg 12H, incr slowly if reqd to max

### 2.5mg 6H oral.

### Anakinra Adult (NOT/kg): 100mg daily SC.

### Anastrozole Adult (NOT/kg): 1mg daily oral.

### Ancestim (human stem cell factor) 20mcg/kg/day SC.

### Aneurine See thiamine.

### Anidulafungin 2-4mg/kg (adult 100-200mg) oral day 1, then 1-

### 2mg/kg (adult 50-100mg) daily.

### Anistreplase Adult (NOT/kg): 30u IV over 5min.

### Anthraquinone See sennoside.

### Antihaemophilic factor See factor 8.

### Anti-inhibitor coagulant complex See factor 8 inhibitor bypassing

### fraction.

### Antilymphocyte globulin See immunoglobulin, antilym'te.

### Antithrombin III No. IU = (desired - actual level) x Wt / 2.2.

### Antithymocyte globulin See immunoglobulin, antilymphocyte.

### Antivenom to Australian box jellyfish, snakes (black, brown, death

### adder, sea, taipan, tiger), spiders (funnel-web) and ticks Dose

### depends on amount of venom injected, not size of patient. Higher

### doses needed for multiple bites, severe symptoms or delayed

### administration. Give adrenaline 0.005mg/kg (0.005ml/kg of 1 in

### 1000) SC. Initial dose usually 1-2 amp diluted 1/10 in Hartman

### Antivenom to black widow spider (USA), red back spider (Australia)

### 1amp IM, may repeat in 2hr. Severe envenomation: 2amp

### diluted 1/10 in Hartmann soltn IV over 30min.

### Antivenom to coral snake (USA) 3-6 vials IV over 1-2hr, repeat if

### signs progress. Premedicate with diphenhydramine 5mg/kg (adult

### 300mg) IV, have adrenaline available.

### Antivenom to Crotalidae (pit vipers, rattlesnakes - USA) 4-6

### vials, with higher dose for more severe envenomation, diluted 1/10

### in saline IV over 1hr, repeated 1hr later if reqd; then 2 vials 6H for 3

### doses.

### Antivenom, stonefish 1000u (2ml) per puncture IM. Severe:

### 1000u/puncture dilutd 1/10 in Hartmann soltn IV over 30min.

### Apomorphine Adult (NOT/kg): usually 2.4-3.6mg/dose (max 6mg)

### prn to max 50mg/day SC. Infsn: 0.02-0.08 mg/kg/hr (max

### 200mg/day) SC.

### Apraclonidine 1 drop/eye 8H (0.5%), 12H (1%).

### Aprepitant Adult (NOT/kg): 125mg oral 1hr before chemo, then

### 80mg on days 2 and 3.

### Aprostadil See alprostadil.

### Aprotinin (1kiu = 140ng = 0.00056epu, 1mg = 7143kiu).

### 1,200,000 kiu/m2 IV over 1hr (plus 1,200,000 kiu/m2 in prime),

### then 300,000 kiu/m2/hr; half for ""low dose"". Adult (NOT/kg):

### 2,000,000 kiu IV over 1hr (plus 2,000,000 kiu in prime), then

### 500,000 kiu/hr; half for ""low dose"". Prophylaxis: 4000 kiu/kg, th

### Arachis oil 130ml enema as required.

### Arachis oil 57% + chlorbutol 5% + dichlorobenzene 16% (Cerumol)

### 5 drops to ear 15-30min before syringing.

### Arformoterol NOT/kg: 15mcg in 2ml 12H by nebulisation.

### Argatroban 2mcg/kg/min; adjust to maintain APTT x1.5-3. .

### Arginine hydrochloride Dose (mg) = BE x Wt(kg) x 70; give half this

### IV over 1hr, then repeat if reqd.

### Arginine vasopressin See vasopressin.

### Argipressin See vasopressin.

### Aripiprazole Adult (NOT/kg): 10-15mg daily oral, incr if reqd after

### 2wk to max 30mg daily.

### Artemether, oily soltn 3.2mg/kg IM stat, then 1.6mg/kg daily unitl

### oral therapy possible.

### Artemether 20mg + lumefantrine 120mg NOT/kg: 1 tab (10-14kg), 2

### tab (15-24kg), 3 tab (25-34kg), 4 tab (>34kg) at 0hr, 8hr, 24hr, 36hr,

### 48hr and 60hr. Repeat dose if vomit within 1hr of ingestion.

### Artemisinin 25mg/kg oral day 1; then 12.5mg/kg daily for 2 days

### (with mefloquine 15-25mg/kg on day 2), or for 4-6 days if

### mefloquine resistance.

### Artesunate Oral: 5mg/kg day 1; then 2.5mg/kg daily for 2 days

### (with mefloquine 15-25mg/kg on day 2), or for 4-6 days if

### mefloquine resistance. IM, or IV over 1-2min: 2mg/kg stat, then

### 1mg/kg in 6hr if hyperparasitic, then 1mg/kg daily until oral therapy

### possible.

### Articane 40mg/ml + adrenaline 1:100,000 Adult (NOT/kg) avge

### dose 1.7ml (max 7mg/kg = 0.175ml/kg) by injection.

### Ascorbic acid Burn (NOT/kg): 200-500mg daily IV, IM, SC, oral.

### Metabolic dis (NOT/kg): 250mg (<7yr) 500mg (>7yr) daily oral.

### Scurvy (NOT/kg): 100mg 8H oral for 10 days. Urine acidification:

### 10-30mg/kg 6H.

### Asparaginase See colaspase.

### Aspirin 10-15mg/kg (adult 300-600mg) 4-6H oral. Antiplatelet: 3-

### 5mg/kg (max 100mg) daily. Kawasaki: 10mg/kg 6H (low dose) or

### 25mg/kg 6H (high dose) for 2wk, then 3-5 mg/kg daily. Arthritis:

### 25mg/kg (max 2g) 6H for 3 days, then 15-20mg/kg 6H. Salicylate

### level (art

### Aspirin 25mg + dipyridamole 200mg Adult (NOT/kg) 1 sustained rel

### cap 12H oral.

### Astemizole 0.2mg/kg (adult 10mg) daily oral.

### Atazanavir >16yr (NOT/kg): 400mg daily oral.

### Atenolol Oral: 1-2mg/kg (adult 50-100mg) 12-24H. IV: 0.05 mg/kg

### (adult 2.5mg) every 5min if reqd (max 4 doses), then 0.1-0.2mg/kg

### (adult 5-10mg) over 10min 12-24H.

### Atomoxetine 0.5mg/kg (>70kg 40mg) daily oral, incr after at least 3

### days to max 1.2mg/kg (>70kg 100mg) as single daily dose or

### divided 12H. .

### Atorvastatin 0.2mg/kg (adult 10mg) daily, incr if reqd every 4wk to

### max 1.6mg/kg (adult 80mg) daily.

### Atosiban Adult (NOT/kg): 6.75mg IV over 1min, then 300 mcg/min

### for 3hr, then 100mcg/min for max 45hr.

### Atovaquone, micronised Pneumocystis: 3-24mo 45mg/kg, >24mo

### 30mg/kg (max 1500mg) daily oral.

### Atovaquone 250mg + proguanil 100mg (Malarone) Malaria

### treatment: 20mg/kg of atovaquone (adult 1g) daily for 3 days oral;

### prophylaxis: 5mg/kg of atovaquone (adult 250mg) daily.

### Atovaquone 62. 5mg + proguanil 25mg (Malarone paediatric).

### Malaria prophylaxis: 5mg/kg (adult 250mg) daily oral.

### Atracurium besylate 0.3-0.6mg/kg stat, then 0.1-0.2mg/kg when

### reqd or 5-10mcg/kg/min IV.

### Atropine 0.02mg/kg (max 0.6mg) IV or IM, then 0.01mg/kg 4-6H.

### Organophosphate poisoning: 0.05-1mg/kg (adult 2mg) IV, then

### 0.02-0.05mg/kg (adult 2mg) every 15-60min until atropinised, then

### 0.02-0.08mg/kg/hr for several days. .

### Atropine 25mcg + diphenoxylate 2. 5mg tab (Lomotil). Adult

### (NOT/kg): 1-2 tab 6-8H oral.

### Attapulgite Adult (NOT/kg): 0.6-1.2g 3-6H oral.

### Auranofin 0.1mg/kg (adult 6mg) daily oral, incr if reqd to max

### 0.05mg/kg (adult 3mg) 8H.

### Aurothioglucose 0.25mg/kg weekly IM, incr to 1mg/kg (max 40mg)

### weekly for 20wk, then every 1-4wk.

### Azacitidine 75mg/m2 SC daily for 7 days, repeated every 4wk;

### incr if reqd after 2 cycles to 100mg/m2 daily.

### Azapropazone 10mg/kg (max 600mg) 12H oral. Acute gout: 6H

### (day 1), 8H (day 2), then 12H.

### Azatadine NOT/kg: 0.5-1mg (child >6yr), 1-2mg (adult) 12-24H

### oral.

### Azathioprine 25-75mg/m2 (approx 1-3mg/kg) daily oral, IV.

### Azelaic acid 20% cream, 15% gel: apply 12H. .

### Azelastine 0.1% spray, >5yr: 0.15ml to each nostril 12H.

### Azidothymidine (AZT) See zidovudine. .

### Azithromycin Oral (only 40% bioavailable): 15mg/kg (adult 500mg)

### on day 1 then 7.5mg/kg (adult 250mg) days 2-5, or 15mg/kg (adult

### 500mg) daily for 3 days; trachoma 20 mg/kg (adult 1g) wkly x3;

### MAC prophylaxis (adult) 1.2g wkly; Gp A strep 20mg/kg daily x3.

### IV: 15mg/kg

### Aztreonam 30mg/kg (adult 1g) 8H IV. Severe inftn: 50mg/kg

### (adult 2g) 12H (1st wk life), 8H (2-4 wk), 6H or infsn (4+ wk). .

### Bacampicillin 15-25mg/kg (adult 400-800mg) 12H oral. .

### Bacillus Calmette-Guerin (BCG) vaccine (CSL) Live. Intradermal

### (1mg/ml): 0.075ml (<3mo) or 0.1ml (>3mo) once. Percutaneous

### (60mg/ml suspension): 1 drop on skin, inoculated with Heaf

### apparatus, once.

### Bacillus Calmette-Guerin (BCG) suspension, about 5 x 10^8 cfu/vial

### Adult: 1 vial (OncoTICE) or 3 vials (ImmuCyst) left in bladder

### for 2hr each wk for 6wks, then at 3, 6, 12, 18 and 24mo.

### Bacitracin 500u/g + polymyxin B 10,000u/g Eye ointment: apply

### x2-5/day.

### Bacitracin 400u/g + polymyxin B 5000u/g + neomycin 5mg/g

### (Neosporin) Ointment or eye ointment: apply x2-5/day. Powder:

### apply 6-12H (skin inftn), every few days (burns). Eye drops: see

### gramicidin.

### Baclofen 0.2mg/kg (adult 5mg) 8H oral, incr every 3 days to 1mg/kg

### (adult 25mg, max 50mg) 8H. Intrathecal infsn: 2-20mcg/kg (max

### 1000mcg) per 24hr.

### Balsalazide Adult (NOT/kg): 2.25g 8H oral (= 2.34g mesalazine

### daily).

### Bambuterol 0.2-0.4mg/kg (adult 10-20mg) nocte oral.

### Basiliximab 12mg/m2 (max 20mg) IV 2hr preop, repeated 4 days

### later.

### BCG vaccine See Bacillus Calmette-Guerin vaccine.

### Beclomethasone dipropionate Rotacap or aerosol (NOT /kg): 100-

### 200mcg (<8yr), 150-400mcg (>8yr) x2/day (rarely x4/day). Nasal

### (NOT/kg): aerosol or pump (50mcg /spray): 1spray 12H (<12yr),

### 2spray 12H (>12yr).

### Bemiparin Surgery (adult, NOT/kg): 2500u (orthopaedics 3500u)

### SC 2hr pre-op or 6hr post-op, then daily for 7-10 days. DVT:

### 115u/kg daily 5-9 days (or until oral anticoag).

### Benazepril 0.2-0.4mg/kg (adult 10-20mg) 12-24H oral.

### Bendroflumethiazide See bendrofluazide.

### Bendrofluazide 0.1-0.2mg/kg (adult 5-10mg) daily oral.

### Benflumetol (lumefantrine) See artemether.

### Benorylate 30mg/kg (adult 1.5g) 8H oral.

### Benperidol 5-15mcg/kg (adult 0.25-1.5mg) 12-24H oral.

### Benserazide See levodopa + benserazide. .

### Benzathine penicillin See penicillin, benzathine.

### Benzatropine See benztropine.

### Benzbromarone Adult (NOT/kg): 50-300mg daily oral, or 20-25mg

### with allopurinol.

### Benzhexol >3yr: 0.02mg/kg (adult 1mg) 8H, incr to 0.1-0.3 mg/kg

### (adult 1.5-5mg) 8H oral.

### Benzocaine 1%-20% topical: usually applied 4-6H.

### Benzoczine + cetylpyridinium Mouth wash (Cepacaine): apply 3H

### prn, do not swallow.

### Benzocane + phenazone 5.4% (Auralgin). 3 drops per ear 3

### times a day for 2-3 days.

### Benzoic acid 6% + salicylic acid 3% Whitfield's ointment: apply 12H.

### Benzonatate 2-4mg/kg (adult 100-200mg) 8H oral.

### Benzoyl peroxide Liquid, gel 2.5%-10%: apply x1-3/day.

### Benzquinamide IM: 0.5-1mg/kg (adult 50mg) stat and repeat in

### 1hr if needed, then 3-4H prn. IV over 1-5min: 0.2-0.4mg/kg (adult

### 25mg) once.

### Benzthiazide 25mg + triamterene 50mg Adult (NOT/kg): 1-2 tab on

### alternate days, oral.

### Benztropine >3yr: 0.02mg/kg (adult 1mg) stat IM or IV, may repeat

### in 15min. 0.02-0.06mg/kg (adult 1-3mg) 12-24H oral.

### Benzyl benzoate 25% lotion. Scabies: apply from neck down after

### hot bath, wash off after 24hr; repeat in 5days. Lice: apply to

### infected region, wash off after 24hr; repeat in 7days.

### Bepridil 4-8mg/kg (adult 200-400mg) daily oral.

### Beractant (bovine surfactant, Survanta) 25mg/ml soltn. 4ml/kg

### intratracheal 2-4 doses in 48hr, each dose in 4 parts: body inclined

### down with head to right, body down head left, body up head right,

### body up head left.

### Beta carotene Porphyria: 1-5mg/kg (adult 30-300mg) daily.

### Betahistine 0.15-0.3mg/kg (adult 8-16mg) 8H oral.

### Betaine hydrochloride Usually 60mg/kg (adult 3g) 12H oral, max

### 100mg/kg (adult 5g) 12H.

### Betamethasone 0.01-0.2mg/kg daily oral. Betamethasone has no

### mineralocorticoid action, 1mg = 25mg hydrocortisone in

### glucocorticoid action. Gel 0.05%; cream, lotion or ointment, 0.02%,

### 0.05%, 0.1%: apply sparingly 8-24H. Eye 0.1%: initially 1drop/eye

### 1-2H, then 6H; or 0

### Betamethasone 0.1% + neomycin 0.5%. 1drop/eye 4-8H.

### Betamethasone acetate 3mg/ml + betamethasone sodium

### phosphate 3. 9mg/ml (Celestone Chronodose). Adult: 0.25-2ml

### (NOT/kg) intramuscular, intra-articular, or intralesional injection.

### Betamethasone dipropionate 0. 064% + calcipotriol 0.005%

### (Dovonex ). Ointment: apply daily to no more than 30% of body

### for up to 4wk (max 100g/wk in adult).

### Betaxolol 0.4-0.8mg/kg (adult 20-40mg) daily oral. Eye drops

### 0.25%-0.5%: 1 drop/eye 12H.

### Bethanecol Oral: 0.2-1mg/kg (adult 10-50mg) 6-8H. SC: 0.05-

### 0.1mg/kg (adult 2.5-5mg) 6-8H.

### Bevacizumab 5mg/kg IV every 14 days.

### Bexarotene 300mg/m2 (range 100-400mg/m2) daily oral.

### Bezafibrate 4mg/kg (adult 200mg) 8H oral with food.

### Bicalutamide Adult (NOT/kg): 50-150mg daily oral.

### Bicalutamide + goserelin Adult (NOT/kg): 50mcg daily oral, +

### goserelin 10.8mg implant 4wkly or 10.8mg SC every 3mo.

### Bicarbonate Slow IV: dose (mmol) = BE x Wt/4 (<5kg), BE x Wt/6

### (child), BE x Wt/10 (adult). These doses correct half the base

### deficit. Alkalinise urine: 0.25mmol/kg 6-12H oral.

### Bifonazole 1% cream: apply daily for 2-4wk.

### Bimatoprost 0.03% drops: 1 drop/eye each evening.

### Bimatoprost 0.3mg/ml + timolol 5mg/ml. 1drop/eye daily.

### Biotin (coenzyme R, vitamin H) NOT/kg: 5-20mg daily IV, IM, SC or

### oral.

### Biperiden hydrochloride 0.02-0.04mg/kg (adult 1-2mg) 8-12H

### oral. IM or slow IV: 0.05-0.1mg/kg (adult 2.5-5mg), max x4/day.

### Bisacodyl NOT/kg: <12mo 2.5mg PR, 1-5yr 5mg PR or 5-10mg

### oral, >5yr 10mg PR or 10-20mg oral. Enema: half daily (6mo-3yr), 1

### enema daily (>3yr).

### Bisacodyl 10mg + docusate sodium 100mg <2yr half suppos, 1-

### 11yr half to 1 suppos, >11yr 1 suppos daily.

### Bismuth subsalicylte 5mg/kg (adult 240mg) 12H oral 30min before

### meal. H.pylori (adult, NOT/kg): 107.7mg x4/day with meals and

### nocte for 2wk + tetracycline 500mg x4/day + metronidazole 200mg

### with meals and 400mg nocte; see also omeprazole + bismuth.

### Bismuth subgallate See bismuth subcitrate.

### Bisoprolol 0.2-0.4mg/kg (adult 10-20mg) daily oral.

### Bitolterol Resp soltn (0.2%): 1ml diluted to 4ml 3-6H (mild), 2ml diltd

### to 4ml 1-2H (moderate), undiltd constant (severe, in ICU). Aerosol

### 370mcg/puff: 1-2 puff 4-6H.

### Bivalirudin 0.75-1mg/kg IV stat, then 1.75-2.5mg/kg/hr for 4hr,

### then stop or give 1.75-2mg/kg/hr for 14-20hr.

### Bleomycin sulfate 10-20u/m2 IM, SC or IV over 15min x1-2/wk. Max

### total dose 250u/m2.

### Blood 4ml/kg packed cells raises Hb 1g%. 1 bag = 300ml.

### Bortezomib 1.3mg/m2 on days 1, 4, 8, 11; then 10 day rest (21

### day cycle, average 6 cycles). Stop if toxicity, then use 1

### mg/m2/dose; stop if toxicity recurs, then use 0.7mg/m2/dose.

### Bosentan 1mg/kg (adult 62.5mg) 12H oral for 1-4wk, then

### 2mg/kg (adult 125mg) 12H. IV: half oral dose.

### Botulinum toxin type A NOT/kg: 1.25-2.5u/site (max 5u/site) IM, max

### total 200u in 30 days. Oesoph achalasia: 100u per session divided

### between 4-6 sites. Hyperhidrosis: 50u/2ml intradermal per axilla

### (given in 10-15 sites).

### Botulinum toxin type B NOT/kg: usual total dose 2,500-10,000u,

### repeated every 3-4mo if reqd.

### Bowel washout See colonic lavage soltn.

### Bretylium tosylate 5mg/kg IV in 1hr, then 5-30 mcg/kg/min. .

### Brinzolamide 1%: 1 drop/eye 8-12H.

### Bromazepam 0.02-0.1mg/kg (adult 1-3mg) 8H oral.

### Bromhexine 0 3mg/kg (adult 16mg) 8H oral for 7 days, then

### 0.15mg/kg (adult 8mg) 8H.

### Bromocriptine 0.025mg/kg (adult 1.25mg) 8-12H, incr wkly to

### 0.05-0.2mg/kg (adult 2.5-10mg) 6-12H oral. Inhibit lactn, NOT/kg:

### 2.5mg 12H for 2wk.

### Brompheniramine 0.1-0.2mg/kg (adult 5-10mg) 6-8H oral, SC, IM or

### slow IV.

### Buclizine 0.25-1mg/kg (adult 12.5-50mg) 8-24H oral.

### Budesonide Metered dose inhaler (NOT/kg): <12yr 50-200 mcg 6-

### 12H, reducing to 100-200mcg 12H; >12yr 100-600 mcg 6-12H,

### reducing to 100-400mcg 12H. Nebuliser (NOT/kg): <12yr 0.5-1mg

### 12H, reducing to 0.25-0.5mg 12H; >12yr 1-2mg 12H, reducing to

### 0.5-1mg 12H. Croup: 2mg

### Budesonide + formoterol NOT/kg: 80mcg/4.5mcg or

### 160mcg/4.5mcg, two inhalations 12H.

### Bumetanide 25mcg/kg (adult 1mg) daily oral, may incr to max

### 50mcg/kg (adult 3mg) 8-12H.

### Bupivacaine Max dose: 2-3mg/kg (0.4-0.6ml/kg of 0.5%). With

### adrenaline: max dose: 3-4mg/kg (0.6-0.8ml/kg of 0.5%). Intrathecal:

### 1mgkg (0.2ml/kg of 0.5%). Epidural: 2mg/kg (0.4ml/kg of 0.5%) stat

### intraop, then 0.25mg/kg/hr (0.2ml/kg/hr of 0.125%) postop.

### Intrapleural:

### Buprenorphine Adult (NOT/kg): 200-800mcg 6-8H sublingual, IM

### or slow IV.

### Bupropion 2-3mg/kg (adult 100-150mg) 8-12H oral.

### Burrow's solution See aluminium acetate soltn.

### Buserelin Adult, NOT/kg. Intranasal: 100mcg 4H, or 150 mcg

### each nostril 8H. Prostate carcinoma: 0.5mg 8H SC for 7 days, then

### 100mcg dose of spray to each nostril x6/day.

### Buspirone 0.1mg/kg (adult 5mg) 8-12H oral, incr to max

### 0.3mg/kg (adult 15mg) 8-12H.

### Busulfan Induction: 0.06mg/kg (max 4mg) daily oral if leucocytes

### >20,000/mm3 and platelets >100,000/mm3. Maintenance: 0.01-

### 0.03mg/kg (max 2mg) daily.

### Butabarbital See secbutobarbitone.

### Butalbital 1-2mg/kg (adult 50-100mg) 8-24H oral.

### Butenafine 1% cream: apply 12-24H for 1-4wk.

### Butobarbitone 2-4mg/kg (adult 100-200mg) nocte oral.

### Butoconazole nitrate 2% vaginal cream: 5g (NOT/kg) nocte.

### Butorphanol IM: 0.02-0.1mg/kg (adult 1-4mg) 3-4H. IV: 0.01-

### 0.05mg/kg (adult 0.5-2mg) 3-4H.

### C1 esterase inhibitor 1u = activity 1ml plasma. 10-50u/kg IV over

### 1hr once (prophylaxis), 12-24H (treatment).

### Cabergoline 10mcg/kg/wk (adult 0.5mg) in 1-2 doses, incr if reqd

### monthly by 10mcg/kg/wk to usually 20mcg/kg/wk (adult 1mg) in 1-4

### doses, max 90mcg/kg/wk (adult 4.5mg). Inhibit lactation: 1mg oral

### stat.

### Caffeine citrate 2mg citrate = 1mg base. 1-5mg/kg (adult 50-

### 250mg) of citrate 4-8H oral, PR. Neonate: 20mg/kg stat of citrate,

### then 5mg/kg daily oral or IV over 30min; weekly level 5-30mg/L

### midway between doses.

### Calcifediol (25-OH D3) Deficiency: 1-2mcg/kg daily oral.

### Calciferol (Vitamin D2) See ergocalciferol.

### Calcipotriene See calcipotriol.

### Calcipotriol 50mcg/g (0.005%) ointment: apply 12-24H. See also

### betamethasone + calcipotriol ointment.

### Calcitonin Hypercalcaemia: 4u/kg 12-24H IM or SC, may incr up

### to 8u/kg 6-12H. Paget's: 1.5-3u/kg (max 160u) x3/wk IM or SC.

### Nasal spray: 200u daily.

### Calcitriol (1,25-OH vitamin D3) Renal failure, vit D resistant rickets:

### 0.02mcg/kg daily oral, incr by 0.02mcg/kg every 4-8wk according to

### serum Ca (adult usually 0.25mcg 12H). .

### Calcium (as carbonate, lactate or phosphate) NOT/kg. Neonate:

### 50mg x4-6/day; 1mo-3yr: 100mg x2-5/day oral; 4-12yr: 300mg x2-

### 3/day; >12yr: 1000mg x1-2/day.

### Calcium carbimide 1-2mg/kg (adult 50-100mg) 12H oral.

### Calcium carbonate Adult NOT/kg: 1250-1500mg (500-600 mg

### calcium) 8H oral with meals for hyperphosphataemia.

### Calcium chloride 10% soltn (0.7mmol/ml Ca): 0.2ml/kg (max 10ml)

### slow IV stat. Requirement <16yr 2ml/kg/day IV. Inotrope: 0.03-

### 0.12ml/kg/hr (0.5-2mmol/kg/day) via CVC.

### Calcium edetate (EDTA) See sodium calciumedetate.

### Calcium folinate NOT/kg: 5-15mg oral, or 1mg IM or IV daily.

### Rescue starting up to 24hr after methotrexate: 10-15 mg/m2 6H for

### 36-48hr IV. Methotrexate toxicity: 100-1000mg/m2 6H IV. Before a

### fluorouracil dose of 370 mg/m2: 200mg/m2 IV daily x5, repeat

### every 3-4wk.

### Calcium gluconate 10% soltn (0.22mmol/ml Ca): 0.5ml/kg (max

### 20ml) slow IV stat. Requirement <16yr 5ml/kg/day IV. Inotrope: 0.5-

### 2mmol/kg/day (0.1-0.4ml/kg/hr) via CVC.

### Calcium heparin See heparin.

### Calcium levofolinate Half the dose of calcium folinate.

### Calcium leucovorin See calcium folinate.

### Calcium polystyrene sulfonate (Calcium Resonium) 0.3-0.6g/kg

### (adult 15-30g) 6H NG (+ lactulose), PR.

### Calfactant 35mg/ml phosphlipids, 0.65mg/ml proteins: 1.5 ml/kg

### intratracheal gradually over 20-30 breaths during inspiration with

### infant lying on one side, then another 1.5 ml/kg with infant lying on

### other side.

### Candesartan 0.1-0.3mg/kg (adult 4-16mg) daily oral.

### Canrenoate 3-8mg/kg (adult 150-400mg) daily IV.

### Capecitabine 1250mg/m2 12H oral for 2wk then 1wk off, in 3wk

### cycles.

### Capreomycin sulphate 20mg/kg (adult 1g) IM daily, decr after 2-4mo

### to 2-3 times per wk.

### Capsaicin Cream 0.025%, 0.075%. Apply 6-8H.

### Captopril Beware hypotension. 0.1mg/kg (adult 2.5-5mg) 8H

### oral, incr if reqd to max 2mg/kg (adult 50mg) 8H. Less hypotension

### if mixed with NG feeds given continuously (or 1-2H).

### Carbachol 0.01%: max 0.5ml in anterior chamber of eye.

### Carbamazepine 2mg/kg (adult 100mg) 8H oral, may incr over 2-

### 4wk to 5-10mg/kg (adult 250-500mg) 8H. Bipolar disorder (adult,

### NOT/kg): 200mg as slow-rel cap 12H oral, incr if reqd to max

### 800mg 12H. Level 20-40umol/L (x0.24=mg/l).

### Carbaryl 0.5% lotion: rub into hair, leave 12hr, shampoo.

### Carbenicillin 382mg tab, adult (NOT/kg): 1-2 tab 4H oral.

### Carbenoxolone sodium Adult (NOT/kg): 20-50mg 6H oral.

### Mouth gel 2%, or 2g granules in 40ml water, apply 6H.

### Carbetocin Adult (NOT/kg): 100mcg IV over 1min, or IM.

### Carbidopa See levodopa + carbidopa.

### Carbimazole 0.4mg/kg (adult 20mg) 8-12H oral for 2wk, then

### 0.1mg/kg (adult 5-10mg) 8-24H.

### Carbinoxamine NOT/kg: 2mg (1-3yr), 2-4mg (3-6yr), 4-8mg

### (>6yr) 6-8H oral.

### Carbocisteine 10-15mg/kg (adult 500-750mg) 8H oral.

### Carboplatin 300-400mg/m2 IV over 60min every 4wk.

### Carboprost (15-Me-PGF2-alpha) Termination (NOT/kg): 250-

### 500mcg 1-4H (max total 12mg) IM. Postpartum hge (NOT/kg):

### 250mcg every 15-120min IM (max total 12mg).

### Carglumic acid 50mg/kg 12H oral, incr to 6H if reqd.

### Carisoprodol 7mg/kg (adult 350mg) 6H oral.

### Carmustine (BCNU) 200mg/m2 IV over 2hr every 6wk (reduce if

### leucocytes <3000/mm3 or platelets <75,000).

### Carnitine, L form IV: 5-15mg/kg (max 1g) 6H. Oral: 25mg/kg 6-12H

### (max 3g/day).

### Carob bean gum (Carobel Instant) NOT/kg: 1 scoop (1.8g) in

### 100ml water, give 10-20ml by spoon; or add half a scoop to every

### 100-200ml of milk.

### Carteolol 0.05-0.2mg/kg (adult 2.5-10mg) daily oral. 1%, 2%:

### 1drop/eye 12H.

### Carvedilol 0.08mg/kg (adult 3.125mg) 12H oral; if tolerated incr

### by 0.08mg/kg (adult 3.125mg) every 1-2wk to max 0.5-0.75mg/kg

### (adult 25mg) 12H.

### Casanthranol + docusate sodium Cap 30mg/100mg (NOT/kg):

### adult 1-2cap 12-24H oral. Syrup 2mg/4mg per ml (NOT/kg): child 5-

### 15ml bedtime, adult 15-30ml 12-24H.

### Caspofungin 70mg/m2 (max 70mg) day 1, then 50mg/m2 (usual

### max 50mg, up to 70mg) daily IV over 1hr.

### Cefaclor 10-15mg/kg (adult 250-500mg) 8H oral. Slow release tab

### 375mg (adult, NOT/kg): 1-2 tab 12H oral.

### Cefadroxil 15-25mg/kg (adult 0.5-1g) 12H oral.

### Cefamandole See cephamandole.

### Cefazolin See cephazolin.

### Cefdinir 14mg/kg (adult 600mg) daily (or in 2 divided doses) oral.

### Cefditoren 4-8mg/kg (adult 200-400mg) 12H oral.

### Cefepime hydrochloride 25mg/kg (adult 1g) 12H IM or IV. Severe

### inftn: 50mg/kg (adult 2g) IV 8-12H or constant infsn.

### Cefixime 5mg/kg (adult 200mg) 12-24H oral.

### Cefodizime 25mg/kg (max 1g) 12H IV or IM.

### Cefonicid 15-50mg/kg (adult 0.5-2g) IV or IM daily.

### Cefoperazone 25-60mg/kg (max 1-3g) 6-12H IV in 1hr or IM.

### Cefotaxime 25mg/kg (adult 1g) 12H (<4wk), 8H (4+wk) IV. Severe

### inftn: 50mg/kg (adult 2-3g) IV 12H (preterm), 8H (1st wk life), 6H (2-

### 4 wk), 4-6H or constant infsn (4+ wk).

### Cefotetan 25mg/kg (adult 1g) 12H IM, IV. Severe inftn: 50mg/kg

### (max 2-3g) 12H or constant infsn.

### Cefoxitin 25-60mg/kg (adult 1-3g) 12H (1st wk life), 8H (1-4wk), 6-

### 8H (>4wk) IV.

### Cefpirome 25-50mg/kg (adult 1-2g) 12H IV.

### Cefpodoxime 5mg/kg (adult 100-200mg) 12H oral.

### Cefprozil 15mg/kg (adult 500mg) 12-24H oral.

### Ceftazidime 15-25mg/kg (adult 0.5-1g) 8H IV or IM. Severe inftn,

### cystic fibrosis: 50mg/kg (max 2g) 12H (1st wk life), 8H (2-4 wk), 6H

### or constant infsn (4+ wk).

### Ceftibuten 10mg/kg (adult 400mg) daily oral.

### Ceftizoxime 25-60mg/kg (adult 1-3g) 6-8H IV.

### Ceftriaxone sodium 25mg/kg (adult 1g) 12-24H IV, or IM (in 1%

### lignocaine). Severe inftn: 50mg/kg (max 2g) daily (1st wk life), 12H

### (2+ wk). Epiglottitis: 100mg/kg (max 2g) stat, then 50mg/kg (max

### 2g) after 24hr. Meningococ proph (NOT/kg): child 125mg, >12yr

### 250mg IM in 1% l

### Cefuroxime Oral (as cefuroxime axetil): 10-15mg/kg (adult 250-

### 500mg) 12H. IV: 25mg/kg (adult 1g) 8H. Severe inftn: 50mg/kg

### (max 2g) IV 12H (1st wk life), 8H (2nd wk), 6H or constant infsn

### (>2wk).

### Celecoxib Usually 2mg/kg (adult 100mg) 12H, or 4mg/kg (adult

### 200mg) daily oral.

### Celiprolol 5-10mg/kg (adult 200-400mg) daily oral.

### Cephalexin 7.5mg/kg (adult 250mg) 6H, or 15mg/kg (adult

### 500mg) 12H oral.

### Cephalothin 15-25mg/kg (adult 0.5-1g) 6H IV or IM. Severe inftn:

### 50mg/kg (max 2g) IV 4H or constant infsn. Irrigation fluid: 2g/L

### (2mg/ml).

### Cephamandole 15-25mg/kg (adult 0.5-1g) 6-8H IV over 10min or

### IM. Severe inftn: 40mg/kg (adult 2g) IV over 20min 4-6H or

### constant infsn.

### Cephazolin 10-15mg/kg (adult 0.5g) 6H IV or IM. Severe inftn:

### 50mg/kg (adult 2g) IV 4-6H or constant infsn. Surgical proph:

### 50mg/kg IV at induction.

### Cephradine Oral: 10-25mg/kg (adult 0.25-1g) 6H. IM or IV: 25-

### 50mg/kg (adult 1-2g) 6H.

### Certoparin Prophylaxis: 60u/kg (adult 3000u) 1-2hr preop, then

### daily SC.

### Cerumol See arachis oil + chlorbutol + dichlorobenzene otic.

### Cetirizine NOT/kg: 2.5mg (6mo-2yr), 2.5-5mg (2-5yr), 5-10mg

### (>5yr) daily oral.

### Cetrorelix (GnRH antagonist) Adult (NOT/kg): 0.25mg SC on

### stimulation day 5, then daily until hCG given.

### Cetuximab 400mg/m2 IV over 2hr, then 250mg/m2 wkly.

### Cetylpyridinium See benzocaine + cetylpyridinium.

### Cevimeline 0.6mg/kg (adult 30mg) 8H oral.

### Charcoal, activated Check bowel sounds present. 1-2g/kg (adult

### 50-100g) NG; then 0.25g/kg hrly if redq. Laxative: sorbitol 1g/kg

### (1.4ml/kg of 70%) once NG, may repeat x1.

### Chenodeoxycholic acid 5-10mg/kg 12H oral.

### Chickenpox vaccine See varicella vaccine.

### Chloral betaine 1.7mg = 1mg chloral hydrate.

### Chloral hydrate Hypnotic: 50mg/kg (max 2g) stat (ICU up to

### 100mg/kg, max 5g). Sedative: 8mg/kg 6-8H oral or PR.

### Chlorambucil Typically 0.1-0.2mg/kg daily oral.

### Chloramphenicol Severe inftn: 40mg/kg (max 2g) stat IV, IM or

### oral; then 25mg/kg (max 1g) daily (1st wk life) 12H (2-4 wk) 8H

### (>4wk) x5 days, then 6H. Eye drop, oint: apply 2-6H. Ear: 4drop 6H.

### Serum level 20-30mg/L 2hr, <15mg/L trough. .

### Chlorbutol See arachis oil + chlorbutol + dichlorobenzene. .

### Chlordiazepoxide 0.1mg/kg (adult 5mg) 12H oral, may incr to max

### 0.5mg/kg (adult 30mg) 6-8H.

### Chlorhexidine 0.1%: catheterisation prep, impetigo. 0.2%:

### mouthwash. 1%: skin disinfection. 2-4%: hand wash.

### Chlorhexidine 0.5% + alcohol 70%. Skin disinfection.

### Chlorhexidine 1.5% + cetrimide 15%. 1/30 in water: cleaning

### tissues, wounds or equipment. 140ml in 1L water: disinfecting skin,

### equipment (soak 2min, rinse in sterile water).

### Chlorhexidine + cetrimide 0.05%/0.5%, 0.1%/1%, 0.15%/0.15%

### soltn: wound cleaning.

### Chlorhexidine 1% + hexamidine 0. 15%. Powder: wounds.

### Chlormethiazole IV (edisylate 0.8%): 1-2ml/kg (8-16 mg/kg) over

### 15min, then 0.5-1ml/kg/hr (4-8mg/kg/hr). Capsule 192 mg base,

### adult (NOT/kg): 2-4cap stat (may repeat in 1-2hr), then 1-2cap 8H,

### oral.

### Chlormezanone 5mg/kg (adult 200mg) 6-8H, or 10mg/kg (adult

### 400mg) at night oral.

### Chlorophyllin copper complex 2mg/kg 8-24H oral.

### Chloroprocaine Max 11mg/kg (max 800mg). With adrenaline

### (1/200,000) max 14mg/kg (max 1000mg).

### Chloroquine, base Oral: 10mg/kg (max 600mg) daily x3 days.

### IM: 4mg/kg (max 300mg) 12H for 3 days. Prophylaxis: 5mg/kg

### (adult 300mg) oral x1/wk. Lupus, rheu arth: 12mg/kg (max 600mg)

### daily, reduce to 4-8mg/kg (max 400mg) daily.

### Chlorothiazide 5-20mg/kg (adult 0.25-1g) 12-24H oral, IV.

### Chlorphenamine See chlorpheniramine.

### Chlorphenasin 1% ointment: apply 12H.

### Chlorpheniramine 0.1mg/kg (adult 4mg) 6-8H oral.

### Chlorpheniramine 1.25mg + phenylephrine 2.5mg in 5ml. Syrup

### (NOT/kg): 1.25-2.5ml (0-1yr), 2.5-5ml (2-5yr), 5-10ml (6-12yr), 10-

### 15ml (>12yr) 6-8H oral.

### Chlorpromazine Oral or PR: 0.5-2mg/kg (max 100mg) 6-8H; up to

### 20mg/kg 8H for psychosis. IM (painful) or slow IV (beware

### hypotension): 0.25-1mg/kg (usual max 50mg) 6-8H. .

### Chlorpropamide Adult (NOT/kg): initially 125-250mg oral, max

### 500mg daily.

### Chlorquinaldol 5% paste: apply 12H.

### Chlortalidone See chlorthalidone.

### Chlortetracycline 3% cream or ointment: apply 8-24H.

### Chlortetracycline 115.4mg + demeclocycline 69.2mg + tetracycline

### 115.4mg . NOT/kg. >12yr: 1 tab 12H oral.

### Chlorthalidone 2mg/kg (max 100mg) 3 times a wk oral.

### Chlorzoxazone 5-15mg/kg (adult 250-750mg) 6-8H oral.

### Cholecalciferol (Vitamin D3) 1 mcg = 40u = 1mcg ergocalciferol

### (qv). Osteodystrophy: 0.2mcg/kg (hepatic) 15-40mcg/kg (renal)

### daily oral.

### Cholera, whole cell plus toxin b subunit recombinant vaccine

### (Dukoral) Inactivated. Dissolve granules in 150ml water. 2-6yr:

### give 75ml x3 doses 1wk apart oral, boost after 6mo. >6yr: give

### 150ml x2 doses 1wk apart, boost after 2yr .

### Cholestyramine NOT/kg. 1g (<6yr) 2-4g (6-12yr) 4g (>12yr) daily

### oral, incr over 4wk to max 1-2x initial dose 8H.

### Choline magnesium trisalicylate See aspirin.

### Choline salicylate, mouth gel (Bonjela) Apply 3H prn.

### Choline theophyllinate (200mg = theophylline 127mg) See

### theophylline.

### Choriogonadotropin alfa Adult (NOT/kg): 250mcg SC.

### Chorionic gonadotrophin NOT/kg. Cryptorchidism all ages: 500-

### 1000u x1-2/wk for 5wk. After FSH: 10,000iu IM once. Men: 7000iu

### IM x2/wk, with 75iu FSH and 75iu LH IM x3/wk.

### Chymopapain Adult (NOT/kg): 2000-4000 picokatal units per

### disc, max 10,000 picokatal units per patient.

### Ciclesonide Inhaltn (adult): 160mcg in the evening, reducing to

### 80mcg if possible.

### Ciclopirox 1% cream or lotion: apply 12H.

### Cidofovir 5mg/kg over 1hr IV on day 0, day 7, then every 14 days

### (given with probenecid). Papilloma: inject 6.25 mg/ml soltn (max

### total 0.6mg/kg) at interval of >= 2wk.

### Cilastatin See imipenem.

### Cilazapril Usually 0.02-0.1mg/kg (adult 1-5mg) daily oral. Renal

### hypertension: 0.005-0.01mg/kg daily oral.

### Cilostazol Adult (NOT/kg): 100mg 12H oral.

### Cimetidine Oral: 5-10mg/kg (adult 300-400mg) 6H, or 20 mg/kg

### (adult 800mg) nocte. IV: 10-15mg/kg (adult 200mg) 12H (newborn),

### 6H (>4wk).

### Cinacalcet Adult (NOT/kg) 30mg daily oral, incr every 2-4wk (to

### max 180mg) to control parathyroid hormone level. Parathyroid

### carcinoma: 30mg 12H, incr every 2-4wk if reqd to control serum Ca

### to max 90mg 6H oral.

### Cinnarizine 0.3-0.6mg/kg (adult 15-30mg) 8H oral. Periph vasc

### dis: 1.5mg/kg (adult 75mg) 8H oral.

### Cinchocaine Max dose 2mg/kg (0.4ml/kg of 0.5%) by injection. Oint

### 0.5% with hydrocortisone 0.5%: apply 8-24H.

### Cinnarizine Adult (NOT/kg): 75mg 8-12H oral.

### Cinoxacin 10mg/kg (adult 500mg) 12H oral.

### Ciprofibrate 2-4mg/kg (adult 100-200mg) daily oral.

### Ciprofloxacin 5-10mg/kg (adult 250-500mg) 12H oral, 4-7mg/kg

### (adult 200-300mg) 12H IV. Severe inftn, or cystic fibrosis: 20mg/kg

### (max 750mg) 12H oral, 10mg/kg (max 400mg) 8H IV; higher doses

### used occasionally. Meningococcus proph: 15mg/kg (max 500mg)

### once oral.

### Ciprofloxacin, eye drops 0.3%. Corneal ulcer: 1drop /15min for

### 6hr then 1drop/30min for 18hr (day 1), 1drop 1H (day 2), 1drop 4H

### (day 3-14). Conjunctivitis: 1 drop 4H; if severe 1 drop 2H when

### awake for 2 days, then 6H.

### Ciprofloxacin, eye ointment 0.3%. Apply 1.25cm 8H for 3 days,

### then 12H for 3 or more days.

### Cisatracurium 0.1mg/kg (child) or 0.15mg/kg (adult) IV stat, then

### 0.03mg/kg if reqd or 1-3mcg/kg/min. ICU: 0.15 mg/kg stat, then (1-

### 10mcg/kg/min) IV. .

### Cisplatin 60-100mg/m2 IV over 6hr every 3-4wk x6 cycles.

### Citalopram 0.4mg/kg (adult 20mg) daily, incr if reqd over 4wk to

### max 0.4mg/kg (adult 60mg) daily oral.

### Citric acid 0. 25g + potassium citrate 1.5g. Urine alkalinisation

### >6yr (NOT/kg): 2 tab 8-12H oral.

### Cladribine Hairy cell leuk: usually 0.09mg/kg/day for 7 days by

### continuous IV infsn. Ch lymph leuk: 0.12mg/kg/day over 2hr IV on

### days 1-5 of 28 day cycle, max 6 cycles.

### Clarithromycin 7.5-15mg/kg (adult 250-500mg) 12H oral. Slow

### release tab, adult (NOT/kg): 0.5g or 1g daily.

### Clavulanic acid See amoxycillin, ticarcillin.

### Clemastine 0.02-0.06mg/kg (adult 1-3mg) 12H oral.

### Clenbuterol Adult (NOT/kg): 20mcg (up to 40mcg) 12H oral.

### Clidinium 0.05-0.1mg/kg (adult 2.5-5mg) 6-8H oral.

### Clindamycin 6mg/kg (adult 150-450mg) 6H oral. IV over 30 min, or

### IM: 5mg/kg 12H (preterm <1wk old), 5mg/kg 8H (preterm >1wk,

### term <1wk), 7.5mg/kg 8H (term >1wk), >28 days 10mg/kg (adult

### 600mg) 8H. Severe inftn (>28 days): 15-20 mg/kg (adult 900mg) 8H

### IV over 1hr. Acn

### Clioquinol 10mg/g cream, 100% powder: apply 6-12H.

### Clobazam 0.1mg/kg (adult 10mg) daily oral, incr if reqd to max

### 0.4mg/kg (adult 20mg) 8-12H oral.

### Clobetasol 0.05% spray, cream, ointment, gel, solution, foam,

### lotion, shampoo: apply 12H.

### Clobetasone 0.1% soltn: 1drop/eye 1-6H.

### Clodronate 10-30mg/kg (adult 0.6-1.8g) IV over 2hr every 2mo; or

### 6mg/kg (adult 300mg) IV over 2hr daily x7 days, then 15-30/mg/kg

### (adult 0.8-1.6g) 12H oral.

### Clofarabine 52mg/m2 IV over 2hr for 5 days every 2-6wk.

### Clofazimine 2mg/kg (adult 100mg) daily oral. Lepra reaction: up to

### 6mg/kg (max 300mg) daily for max 3mo.

### Clofibrate 10mg/kg 8-12H oral.

### Clomethiazole Equivalent action: cap 192mg base, tab 500mg

### edisylate, syrup 250mg edisylate in 5ml. Adult (NOT/kg): 1-2 cap or

### tab, or 5-10ml syrup, at bedtime oral.

### Clomiphene Adult (NOT/kg): 50mg daily for 5 days oral, incr to

### 100mg daily for 5 days if no ovulation.

### Clomipramine 0.5-1mg/kg (adult 25-50mg) 12H oral, incr if reqd

### to max 2mg/kg (adult 100mg) 8H.

### Clonazepam 1 drop = 0.1mg. 0.01mg/kg (max 0.5mg) 12H oral,

### slowly incr to 0.05mg/kg (max 2mg) 6-12H oral. Status (may be

### repeated if ventilated), NOT/kg: neonate 0.25mg, child 0.5mg, adult

### 1mg IV. .

### Clonidine Hypertension: 1-5mcg/kg slow IV, 1-6mcg/kg (adult

### 50-300mcg) 8-12H oral. Migraine: start with 0.5 mcg/kg (adult 50-

### 75mcg) 12H oral. Analgesia: 2.5mcg/kg premed oral, 0.3 mcg/kg/hr

### IV, 1-2mcg/kg local block; ventld 0.5-2 mcg/kg/hr (<12kg

### 1mcg/kg/hr is 50mc

### Clopidogrel 1.5mg/kg (adult 75mg) daily oral.

### Clorazepate 0.3-2mg/kg (adult 15-90mg) daily at night oral, or 0.1-

### 0.5mg/kg (adult 5-30mg) 8H.

### Clostridia antitoxin See gas gangrene antitoxin.

### Clotrimazole Topical: 1% cream or solution 8-12H. Vaginal

### (NOT/kg): 1% cream or 100mg tab daily for 6 days, or 2% cream or

### 500mg tab daily for 3 days.

### Cloxacillin 15mg/kg (adult 500mg) 6H oral, IM or IV. Severe

### inftn: 25-50mg/kg (adult 1-2g) IV 12H (1st wk life), 8H (2-4wk), 4-6

### H (>4wk) or constant infsn (>4wk).

### Clozapine 0.5mg/kg (adult 25mg) 12H oral, incr over 7-14 days

### to 2-5mg/kg (adult 100-300mg) 8-12H; later reducing to 2mg/kg

### (adult 100mg) 8-12H.

### Coagulation factor, human (Prothrombinex) Factors 2, 9 and 10;

### 250u/10ml. 1ml/kg slow IV daily. Risk of thrombosis in acute liver

### failure.

### Coal tar, topical 0.5% incr to max 10%, applied 6-8H.

### Cocaine Topical: 1-3mg/kg.

### Codeine phosphate Inactive in approx. 10% of adults, poor

### activity in children <5yrs. Analgesic: 0.5-1mg/kg (adult 15-60mg) 4H

### oral, IM, SC. Cough: 0.25-0.5mg/kg (adult 15-30mg) 6H.

### Co-danthramer, co-danthrusate See dantron.

### Co-dergocrine mesylate Adult (NOT/kg): usually 3.0-4.5mg daily

### before meal oral or sublingual; 300mcg daily IM, SC or IV infsn.

### Coenzyme Q10 See ubidecarenone.

### Colaspase Test 2-50u intradermal. Typical dose 6000u/m2 every

### 3rd day x9 doses IV over 4hr, IM or SC.

### Colchicine Acute gout: 0.02mg/kg (adult 1mg) 2H oral (max 3

### doses/day). Chronic use (gout, FMF): 0.01-0.04mg/kg (adult 0.5-

### 2mg) daily oral.

### Colesevelam 625mg tab. Adult (NOT/kg): 3 tab 12H oral, or 6 tab

### daily. With statin: 4-6 tab/day (in 1-2 doses). .

### Colestipol hydrochloride 0.1-0.2g/kg (adult 5-10g) 8H oral.

### Colfosceril palmitate (Exosurf Neonatal) Soltn 13.5 mg/ml.

### Prophylaxis: 5ml/kg intratracheal over 5min straight after birth, and

### at 12hr and 24hr if still ventilated. Rescue: 5ml/kg intratracheal over

### 5min, repeat in 12hr if still ventilated.

### Colistimethate See colistin sulfomethate sodium.

### Colistin sulphomethate sodium 2.6mg = 1mg colistin base =

### 30,000u. IM, or IV over 5min: 40,000u/kg (adult 2 million u) 8H, or

### 1.25-2.5mg/kg of colistin base 12H. Oral or inhaled: 30,000-60,000

### u/kg (adult 1.5-3 million u) 8H.

### Colonic lavage, macrogol-3350 and macrogol-4000 (polyethylene

### glyol) 105g/L Poisoning, severe constipation: if bowel sounds

### present, 25ml/kg/hr (adult 1.5L/hr) oral or NG for 2-4hr (until rectal

### effluent clear). Before colonoscopy: clear fluids only to noon, 1

### whole 5mg bisacodyl tab per 10kg (adult 4 tab) at noon, wait for

### bowel

### Colony stimulating factors See ancestrim, epoetin, filgrastim,

### lenograstim, molgramostim, sargramostim.

### Coloxyl See docusate sodium.

### Conivaptan Adult (NOT/kg): 20mg over 30min IV, then 20mg (max

### 40mg) over 24hr by IV infusion. .

### Conjugated oestrogens (CO) + medroxyprogesterone (MP)

### NOT/kg. CO (NOT/kg): 0.625mg (0.3-1.25mg) daily

### continuously, with MP 10mg (up to 20mg) daily oral for last 10-14

### days of 28 day cycle.

### Co-cyprindiol See cyproterone acetate + ethinyloestradiol.

### Corticorelin 1-2mcg/kg (max 100mcg) IV.

### Corticotrophin releasing factor, hormone See corticorelin.

### Cortisone acetate 1-2.5mg/kg 6-8H oral. Physiological: 7.5 mg/m2

### 8H. Cortisone acetate 1mg = hydrocortisone 1.25mg in mineraloand

### gluco-corticoid action.

### Cosyntropin (ACTH subunit) NOT/kg: <2yr 0.125mg, >2yr 0.25-

### 0.75mg IM, IV, or infused over 4-8hr.

### Cotrimoxazole (trimethoprim 1mg + sulphamethoxazole 5mg)

### TMP 1.5-3mg/kg (adult 80-160mg) 12H IV over 1hr or oral.

### Renal proph: TMP 2mg/kg (max 80mg) daily oral. Pneumocystis:

### proph TMP 5mg/kg daily on 3 days/wk; treatment TMP 250mg/m2

### stat, then 150mg/m2 8H (<11yr) or 12H (> 10yr) IV over 1hr; in

### renal failure

### Coumarin Oral: 1-8mg/kg (adult 50-400mg) daily. Cream

### 100mg/g: apply 8-12H.

### Coxiella burnetti vaccine Inactivated. 0.5ml SC once.

### Cromoglycate See sodium cromoglycate.

### Cromolyn, sodium See sodium cromoglycate.

### Crotamiton 10% cream or lotion: apply x2-3/day.

### Cryoprecipitate Low factor 8: 1u/kg incr activity 2% (half life

### 12hr); usual dose 5ml/kg or 1bag/4kg 12H IV for 1-2 infns (muscle,

### joint), 3-6 infns (hip, forearm, retroperitoneal, oropharynx), 7-14

### infns (intracranial). Low fibrinogen: usually 5ml/kg or 1bag/4kg IV.

### Bag

### Cyanocobalamin (Vit B12) 20mcg/kg (adult 1000mcg) IM daily for 7

### days then wkly (treatment), monthly (prophylaxis). IV dangerous in

### megaloblastic anaemia. Maintenance treatment (adult NOT/kg):

### 2mg daily oral, 500mcg wkly nasal.

### Cyclizine 1mg/kg (adult 50mg) 8H oral, IM or IV. .

### Cyclizine 30mg + dipipanone 10mg Adult (NOT/kg): 1 tab 6H oral,

### incr dose by half tab if reqd to max 3 tab 6H.

### Cyclobenzaprine 0.2-0.4mg/kg (adult 5-15mg) 8H oral. Extendedrelease

### (adult, NOT/kg): 15mg or 30mg daily oral.

### Cyclopenthiazide 5-10mcg/kg (adult 250-500mcg) 12-24H .

### Cyclopentolate 0.5%, 1%: 1 drop/eye, repeat after 5min.

### Pilocarpine 1% speeds recovery.

### Cyclophosphamide A typical regimen is 600mg/m2 IV over

### 30min daily for 3 days, then 600mg/m2 IV wkly or 10mg/kg twice

### wkly (if leucocytes >3000/mm3).

### Cycloserine 5-10mg/kg (adult 250-500mg) 12H oral. Keep plasma

### conc <30mcg/ml.

### Cyclosporin 1-3mcg/kg/min IV for 24-48hr, then 5-8mg/kg 12H

### reducing by 1mg/kg/dose each mo to 3-4 mg/kg/dose 12H oral.

### Eczema, juvenile arthritis, nephrotic, syndrome, psoriasis: 1.5-

### 2.5mg/kg 12H. Usual target trough levels by Abbott TDx

### monoclonal specific assay (x

### Cyclosporin ophthalmic 0.05% 1 drop in each eye 12H.

### Cyproheptadine 0.1mg/kg (adult 4mg) 6-8H oral. Migraine

### 0.1mg/kg (adult 4mg), repeated in 30min if reqd.

### Cyproterone acetate 1mg/kg (adult 50mg) 8-12H oral. Prec

### puberty: 25-50mg/m2 8-12H oral. Hyperandrogenism: 50-100mg

### daily days 5-14, with oestradiol valerate 1mg daily days 5-25.

### Prostate carcinoma (NOT/kg): 100mg 8-12H oral. See also

### oestradiol + cyproterone.

### Cyproterone acetate + ethinyloestradiol (2mg/35mcg) x 21 tab, + 7

### inert tab In females for acne, contraception, or hirsutism: 1 tab

### daily, starting 1st day of mensturation.

### Cysteamine bitartrate 0.05mg/m2 6H oral, incr over 6wk to

### 0.33mg/m2/dose (<50kg) or 0.5mg/kg/dose (>50kg) 6H.

### Cytarabine Usually 100mg/m2 daily for 10 days by IV injn or

### constant infsn. Intrathecal: 30mg/m2 every 4 days until CSF normal

### (dissolve in saline not diluent).

### Cytomegalovirus immunoglobn See immunoglobn, CMV.

### Dacarbazine 250mg/m2 IV daily for 5 days every 3wk.

### Daclizumab 1mg/kg IV over 15min every 2wk for 5 doses.

### Dactinomycin Usually 400-600mcg/m2 IV daily for 5 days,

### repeat after 3-4wk.

### Dalfopristin 350mg + quinupristin 150mg (Synercid IV 500mg vial)

### 7.5mg/kg (combined) 8H IV over 1hr.

### Dalteparin sodium Proph (adult): 2500-5000u SC 1-2hr preop,

### then daily. Venous thrombosis: 100u/kg 12H SC, or infuse

### 200u/kg/day IV (anti-Xa 0.5-1u/ml 4hr post dose). Haemodialysis:

### 5-10u/kg stat, then 4-5u/kg/hr IV (acute renal failure, anti-Xa 0.2-

### 0.4u/ml); 30-40u/kg sta

### Danaparoid Prevention: 15u/kg (adult 750u) 12H SC. Heparin

### induced thrombocytopenia: 30u/kg stat IV, then 1.2-2u/kg/hr to

### maintain anti-Xa 0.4-0.8u/ml.

### Danazol 2-4mg/kg (adult 100-200mg) 6-12H oral.

### Dantrolene Hyperpyrexia: 1mg/kg/min until improves (max

### 10mg/kg), then 1-2mg/kg 6H for 1-3day IV or oral. Spasticity:

### 0.5mg/kg (adult 25mg) 6H, incr over 2wk if reqd to 3mg/kg (adult

### 50-100mg) 6H oral.

### Dantron + docusate (co-danthrusate) NOT/kg. 50/60mg cap: 7-

### 12yr 1cap, adult 1-3cap at night. 50/60mg in 5ml: 1-6yr 2.5ml, 7-

### 12yr 5ml, adult 5-15ml at night.

### Dantron + poloxamer 188 (co-danthramer) NOT/kg. 25/ 200mg

### cap: 7-12yr 1cap, adult 1-3cap at night. 25/200mg in 5ml: 1-6yr

### 2.5ml, 7-12yr 5ml, adult 5-15ml at night.

### Dapsone 1-2mg/kg (adult 50-100mg) daily oral. Derm herpet: 1-

### 6mg/kg (adult 50-300mg) daily oral. .

### Dapsone 100mg + pyrimethamine 12. 5mg (Maloprim). 1-4yr

### quarter tab wkly, 5-10yr half tab, >10yr 1tab. .

### Daptomycin 4mg/kg IV over 30min daily.

### Darbepoetin alfa Incr or reduce dose if reqd by 25% every 4wk.

### Renal failure: 0.45mcg/kg wkly (0.75mcg/kg wkly if not on dialysis)

### SC or IV. Cancer: 6.75mcg/kg every 3wk, or 2.25mcg/kg every wk,

### SC or IV.

### Darifenacin Adult (NOT/kg): 7.5-15mg daily oral.

### Darunavir Adult (NOT/kg): 600mg 12H oral.

### Dasatinib Adult (NOT/kg): 70mg (up to 100mg) 12H oral.

### Daunorubicin 30mg/m2 wkly slow IV, or 60-90mg/m2 every 3wk.

### Max total dose 500mg/m2.

### DDAVP See desmopressin.

### Decitabine 15mg/m2 IV over 3hr 8H for 3 days, repeated every

### 6wk (minimum of 4 cycles).

### Deferasirox 20mg/kg (15-30mg/kg) daily oral.

### Deferiprone 25mg/kg 8H (max 100mg/kg/day) oral.

### Deferoxamine See desferrioxamine.

### Deflazacort Usually 0.1-1.5mg/kg (adult 5-90mg) 24-48H oral. 1.2

### mg = 1mg prednisolone in glucocorticoid activity.

### Delavirdine Adult (NOT/kg): 400mg 8H, or 600mg 12H oral.

### Demecarium bromide 0.125%, 0.25% ophthalmic soltn. Glaucoma:

### 1 drop x2/day to x2/wk. Strabismus: 1 drop daily for 2wk, then 1

### drop alternate days for 2-3wk.

### Demeclocycline >8yr: 3mg/kg (adult 150mg) 6H, or 6mg/kg (adult

### 300mg) 12H oral. See also chlortetracycline.

### Denileukin diftitox 9-18mcg/kg daily IV over 15min for 5 consecutive

### days every 21 days.

### Dequalinium NOT/kg: one 0.25mg pastile 4H oral.

### Deserpidine 0.005-0.02mg/kg (adult 0.25-1mg) daily oral.

### Desferrioxamine Antidote: 10-15mg/kg/hr IV for 12-24hr (max

### 6g/24hr) if Fe >60-90umol/l at 4hr or 8hr; some also give 5-10g

### (NOT/kg) once oral. Thalassaemia (NOT/kg): 500mg per unit blood;

### and 5-6 nights/wk 1-3g in 5ml water SC over 10hr, 0.5-1.5g in 10ml

### water SC over 5

### Desirudin 0.3mg/kg (adult 15mg) 12H SC.

### Desloratadine 0.1mg/kg (adult 5mg) daily oral.

### Desmopressin (DDAVP) 1u = 1mcg. Nasal (NOT/kg): 5-10mcg

### (0.05-0.1ml) per dose 12-24H; enuresis 10-40mcg nocte. IV: 0.5-

### 2mcg in 1L fluid, and replace urine output + 10% hrly (but much

### better to use vasopressin). Haemophilia, von Wille: 0.3mcg/kg

### (adult 20mcg) IV over 1hr 12-24

### Desogestrel Contraception: 75mcg daily oral, starting 1st day of

### menstruation.

### Desogestrel + ethinyloestradiol (150mcg/30mcg, 150/20) x21 tab, +

### 7 inert tab Contraception: 1 tab daily, starting 1st day of

### menstruation. .

### Desonide 0.05% cream, ointment, lotion: apply 8-12H.

### Desoximetasone See desoxymethasone.

### Desoxymethasone 0.05% or 0.25% cream, oint, gel: apply 12H.

### Desoxyribonuclease See fibrinolysin. .

### Dexamethasone 0.1-0.25mg/kg 6H oral, IM or IV. BPD: 0.1mg/kg

### 6H for 3 days, then 8H 3 days, 12H 3 days, 24H 3 days, 48H 7

### days. Cerebral oedema: 0.25-1mg/kg (adult 10-50mg) stat, then

### 0.1-0.2mg/kg (adult 4-8mg) 4H IV reducing over 3-5 days to

### 0.05mg/kg (adult 2mg) 8-12

### Dexamethasone 0.5mg/ml (0.05%) + framycetin 5mg/ml (0.5%) +

### gramicidin 0.05mg/ml (0.005%) (Sofradex ). Eye 1 drop 1-3H,

### ear 2-3 drops 6-8H, ointment 8-12H.

### Dexamethasone 0. 1% + neomycin 0.35% + polymyxin 6000u/g.

### 1drop/eye 6-8H.

### Dexamethasone 0. 1% + tobramycin 0.3%. Usually 1drop/ eye 4-

### 6H; up to 2H for 2 days after surgery if reqd.

### Dexamethasone 20mcg + tramazoline 120mcg per dose Aerosol:

### 1 puff in each nostril 4-8H.

### Dexamphetamine 0.2mg/kg (max 10mg) daily oral, incr if reqd to

### max 0.6mg/kg (max 40mg) 12H.

### Dexchlorpheniramine maleate 0.05mg/kg (adult 2mg) 6-8H oral.

### Repetab (adult NOT/kg): 6mg 12H oral.

### Dexfenfluramine Adult: 15mg (NOT/kg) 12H oral.

### Dexibuprofen Adult (NOT/kg): 400mg 12H (max 8H) oral.

### Dexketoprofen Adult (NOT/kg): 12.5mg 4-6H, or 25mg 8H (max

### 75mg/day) oral.

### Dexmedetomidine ICU: 1mcg/kg IV over 15min, then 0.2-

### 0.7mcg/kg/hr for max 24hr.

### Dexmethylphenidate NOT/kg, given as two doses/day 4hr apart:

### 2.5mg/dose oral, incr if reqd to 10mg/dose. Use half the dose of

### racemic methylphenidate.

### Dexpanthenol 5-10mg/kg (adult 250-500mg) IM. 5% cream:

### apply 12-24H.

### Dexrazoxane 10mg for each 1mg doxorubicin IV. Extravasation of

### anthracyclines: within 6hr give 1g/m2 (max 2g) IV over 2hr,

### repeated after 24hr; then 0.5g/m2 48hr after first dose.

### Dextran 1 (Promit) 15% soltn. 0.3ml/kg IV 1-2min before giving

### dextran 40 or dextran 70.

### Dextran 40 10% soltn: 10ml/kg x1-2 on day 1, then 10ml/kg/day

### IV. Half life about 3hr.

### Dextran 70 6% soltn: 10ml/kg x1-2 on day 1, then 10ml/kg/day IV.

### Half life about 12hr.

### Dextroamphetamine See dexamphetamine.

### Dextromethorphan hydrobromide 0.2-0.4mg/kg (adult 10-20mg)

### 6-8H oral.

### Dextromoramide 0.1mg/kg (adult 5mg) 8H, may incr to 0.5mg/kg

### (adult 20mg) 8H oral or PR.

### Dextropropoxyphene Hydrochloride 1.3mg/kg (adult 65mg) or

### napsylate 2mg/kg (adult 100mg) 6H oral.

### Dextrose Infant sedation (NOT/kg): 1ml 50%D oral.

### Hypoglycaemia: 0.5ml/kg 50%D or 2.5ml/kg 10%D slow IV, then

### incr maintenance infsn rate. Hyperkalaemia: 0.1u/kg insulin +

### 2ml/kg 50%D IV. Neonates: 6g/kg/day (about 4mg/kg/min) day 1,

### incr to 12 g/kg/day (up to 18g

### Dextrose-heparin (dex-hep) Dextrose soltn (usually 5%) with

### heparin 1u/ml. .

### Dextrothyroxine Adult (NOT/kg): 1-2mg daily oral, incr monthly if

### reqd to max 4-8mg daily.

### Dezocine IM: 0.1-0.4mg/kg (adult 5-20mg) 3-6H. IV: 0.05-

### 0.2mg/kg (adult 2.5-10mg) 2-4H.

### 3,4-Diaminopyridine Adult (NOT/kg): 10mg 6-8H oral, incr if reqd

### to max 20mg x5/day.

### Diamorphine Adult (NOT/kg): 5-10mg 4H IV, IM, SC, oral.

### Diazepam 0.1-0.4mg/kg (adult 10-20mg) IV or PR. 0.04-0.2

### mg/kg (adult 2-10mg) 8-12H oral. Do not give by IV infsn (binds to

### PVC); emulsion can be infused. Premed: 0.2-0.4mg/kg oral, PR. 2-

### 3mg = 1mg midazolam.

### Diazoxide Hypertension: 1-3mg/kg (max 150mg) stat by rapid IV

### injection (severe hypotension may occur) repeat once if reqd, then

### 2-5mg/kg IV 6H. Hyperinsulinism: <12mo 5mg/kg 8-12H oral;

### >12mo 30-100mg/m2 per dose 8H oral.

### Dibromopropamidine 0.15% cream on dressing prn.

### Dibucaine See cinchocaine.

### Dichloralphenazone 100mg + isometheptene mucate 65mg +

### paracetamol 325mg (Midrin) Adult (NOT/kg): 2 capsules stat,

### then 1/hr if reqd (max 5cap in 12hr).

### Dichlorobenzene See arachis oil + chlorbutol. .

### Dichlorphenamide 2-4mg/kg (adult 100-200mg) stat, then

### 2mg/kg (adult 100mg) 12H until response, then 0.5-1mg/kg (adult

### 50mg) 8-24H oral.

### Diclofenac 1mg/kg (adult 50mg) 8-12H oral, PR. Eye drops 0.1%:

### preop 1-5 drops over 3hr, postop 1 drop stat, then 1 drop 4-8H.

### Topical gel 1% (arthritis) 3% (keratoses): apply 2-4g 6-8H. Patch

### 1.3% (180mg) 10x14cm: apply 12H.

### Diclofenac + misoprostal Adult, NOT/kg. 50mg/200mcg tab 8-12H

### oral; 75mg/200mcg tab 12H oral.

### Dicloxacillin 15-25mg/kg (adult 250-500mg) 6H oral, IM or IV.

### Severe inftn: 25-50mg/kg (max 2g) IV 12H (1st wk life), 8H (2-4

### wk), 4-6H or constant infsn (>4 wk).

### Dicobalt edetate 10mg/kg (adult 300mg) IV over 1-5min, repeat x2

### if no response.

### Dicyclomine 0.5mg/kg (adult 10-20mg) 6-8H oral.

### Didanosine <90 days: 50mg/m2 12H oral. >90 days: 120mg/m2

### (max 200mg) 12H, or 240mg/m2 (max 400mg) daily oral. CNS

### disease: 150mg/m2 12H.

### Dideoxycytidine (ddC) See zalcitabine.

### Dienoestrol 0.01% vaginal cream: 1 applicatorful (5g) 12-24H for

### 1-2wk, reducing gradually to x1-3/wk.

### Diethylcarbamazine 6mg/kg daily for 12 days oral, or a single

### dose of 6mg/kg repeated every 6-12 months.

### Diethylpropion hydrochloride 6-12yr: 25mg (NOT/kg) 12H oral.

### >12yr: 25mg (NOT/kg) 6-8H oral.

### Diflorasone 0.05% cream, ointment: apply 6-24H.

### Diflunisal 5-10mg/kg (adult 250-500mg) 12H oral.

### Digitoxin 4mcg/kg (max 0.2mg) 12H oral for 4 days, then 1-6mcg/kg

### (adult usually 0.15mg, max 0.3mg) daily.

### Digoxin 15mcg/kg stat and 5mcg/kg after 6H, then 3-5 mcg/kg

### (usual max 200mcg IV, 250mcg oral) 12H slow IV or oral. Level 6hr

### or more after dose: 1.0-2.5 nmol/L (x0.78=ng/ml).

### Digoxin immmune FAB (antibodies) IV over 30min. Dose (to

### nearest 40mg) = serum digoxin (nmol/L) x Wt (kg) x 0.3, or mg

### ingested x 55. Give if >0.3mg/kg ingested, or level >6.4 nmol/L or

### 5.0ng/ml.

### Dihydrocodeine 0.5-1mg/kg 4-6H oral.

### Dihydroergotamine mesylate Adult (NOT/kg): 1mg IM, SC or IV,

### repeat hrly x2 if needed. Max 6mg/wk.

### Dihydrotachysterol (1-OH vitamin D2) Renal failure, vit D

### resistant rickets: 20mcg/kg daily oral, incr by 20mcg/kg every 4-8wk

### according to serum calcium.

### Dihydrotestosterone See stanolone.

### Dihydroxyacetone 5% soltn: apply 1-3 coats 1hr apart, every 1-

### 3 days.

### Di-iodohydroxyquinoline 10-13.3mg/kg (adult 650mg) 8H oral for

### 20 days.

### Diloxanide furoate 10mg/kg (adult 500mg) 8H oral.

### Diltiazem 1mg/kg (adult 60mg) 8H, incr if reqd to max 3mg/kg

### (adult 180mg) 8H oral. Slow release (adult, NOT/kg): 120-240mg

### daily, or 90-180mg 8-12H oral.

### Dimenhydrinate 1-1.5mg/kg (adult 50-75mg) 4-6H oral, IM or IV.

### Dimercaprol (BAL) 3mg/kg (max 150mg) IM 4H for 2 days, then

### 6H for 1 day, then 12H for 10 days.

### Dimethicone Infant colic (NOT/kg): 40mg/ml, 1-2 dropperfuls before

### each feed. 10%, 15% barrier cream: apply prn.

### Dimethindene 0.02-0.04mg/kg (adult 1-2mg) 8H oral.

### Dimethyl sulfoxide (DMSO) 50% soltn: 50ml in bladder for 15

### min every 2wk.

### Dinoprost (Prostaglandin F2 alpha) Extra-amniotic: 1ml of

### 250mcg/ml stat, then 3ml 2H. Intra-amniotic: 40mg stat, then 10-

### 40mg after 24hr if required.

### Dinoprostone (Prostaglandin E2) Labour induction: 1mg into

### posterior vagina, may repeat dose 1-2mg after 6hr (max 60mcg/kg

### over 6hr). Maintain PDA: 25mcg/kg 1H (less often after 1wk) oral;

### or 0.003-0.01mcg/kg/min IV. .

### Dioctyl sodium sulphosuccinate See docusate sodium.

### Diphemanil methylsulphate 20mg/g powder: apply 8-12H.

### Diphenhydramine hydrochloride 1-2mg/kg (adult 50-100mg) 6-

### 8H oral.

### Diphenoxylate See atropine + diphenoxylate (Lomotil). .

### Diphtheria antitoxin (horse) IM or IV (NOT/kg): 2500u (nasal),

### 10,000u (unilateral tonsillar), 20,000u (bilateral tonsillar), 30,000u

### (laryngeal), 50,000u (beyond tonsillar fossa), 150,000u (bullneck).

### Repeat dose may be needed. See also immunoglobulin, diphtheria.

### Diphtheria vaccine, adult (CSL) Inactivated. 0.5ml IM stat, 6wk later,

### and 6mo later (3 doses). Boost every 10yr.

### Diphtheria vaccine, child <8yr (CSL) Inactivated. 0.5ml IM stat, in

### 6wk, then 6mo (3 doses). Boost with adult vaccine.

### Diphtheria + hepatitis B + pertussis (acellular) + polio + tetanus

### [DaPT-HepB-IPV] (Pediarix) Inactivated. 0.5ml IM at 2mo, 4mo,

### 6mo (3 doses), and (DaPT) 18mo.

### Diphtheria + hepatitis B + pertussis (acellular) + tetanus vaccine

### [DaPT-hepB] (Infanrix Hep B) Inactivated. 0.5ml IM at 2mo, 4mo,

### 6mo (3 doses), and (without hep B) 18mo.

### Diphtheria + hepatitis B + Hib + pertussis (acellular) + tetanus

### vaccine [DaPT-hepB-Hib] (Infanrix Hexa) Inactivated. 0.5ml IM

### at 2mo, 4mo, 6mo (3 doses).

### Diphtheria + Hib + pertussis (acellular) + polio + tetanus [DaPT-Hib-

### IPV] (Infanrix Penta, Pediacel) Inactivated. 0.5ml IM at 2mo, 4mo,

### 6mo (3 doses), and (DaPT) 18mo.

### Diphtheria + pertussis (whole cell) + tetanus vaccine [DPT] (Triple

### Antigen) Inactivated. 0.5ml IM at 2mo, 4mo, 6mo, 18mo and 4-5yr

### of age (5 doses).

### Diphtheria + pertussis (acellular) + tetanus vaccine [DaPT]

### (Tripacel) Inactivated. 0.5ml IM at 2mo, 4mo, 6mo, 18mo and 4-

### 5yr of age (5 doses).

### Diphtheria + pertussis (acellular) + tetanus vaccine, adult [daPt]

### (Adacel, Boostrix) Inactivated. >10yr: 0.5ml IM.

### Diphtheria + pertussis (acellular) + polio + tetanus vaccine [DaPTIPV]

### (Quadracel) Inactivated. 0.5ml IM at 2, 4 and 6mo (3 doses).

### Diphtheria + pertussis (acellular) + polio + tetanus vaccine [DaPTIPV]

### (Infanrix-IPV) Inactivated. 16mo-13yr: 0.5ml IM once as

### booster.

### Diphtheria + pertussis (acellular) + polio + tetanus vaccine [daPTIPV]

### (Repevax) Inactivated. >3yr: 0.5ml IM once as booster.

### Diphtheria + pertussis (acellular) + polio + tetanus vaccine, adult

### [daPt-IPV] (Adacel Polio, Boostrix-IPV) Inactivated. >10yr: 0.5ml

### IM once as booster.

### Diphtheria + polio + tetanus vaccine [dT-IPV] (Revaxis)

### Inactivated. >6yr: 0.5ml IM once as booster.

### Diphtheria + tetanus vaccine, adult [dt] (ADT Booster) Inactivated.

### 0.5ml IM for revaccination after primary course.

### Diphtheria + tetanus vaccine, child <8yr [DT] (CDT) Inactivated.

### 0.5ml IM, in 6wk, 6mo later (3 dose). Boost with ADT.

### Dipipanone See cyclizine. .

### Diprophylline Usually 15mg/kg 6H oral or IM.

### Dipyridamole 1-2mg/kg (adult 50-100mg) 6-8H oral. See also

### aspirin + dipyridamole.

### Dirithromycin 10mg/kg (adult 500mg) daily oral.

### Disodium clodronate See sodium clodronate.

### Disodium edetate See trisodium edetate.

### Disodium etidronate See etidonrate.

### Disodium pamidronate See pamidronate. .

### Disopyramide Oral: 1.5-4mg/kg (adult 75-200mg) 6H. IV:

### 2mg/kg (max 150mg) over 5min, then 0.4mg/kg/hr (max

### 800mg/day). Level 9-15umol/L (x0.3395 = mcg/ml).

### Distigmine Neurogenic bladder, megacolon: 0.01mg/kg (adult

### 0.5mg) IM daily, 0.1mg/kg (adult 5mg) oral daily. Myasth gravis:

### 0.1-0.2mg/kg 12-24H (max 20mg/day) oral.

### Disulfiram Adult (NOT/kg): 500mg oral daily for 1-2wk, then 125-

### 500mg daily.

### Dithranol 0.1%-2% cream, ointment: start with lowest strength,

### apply daily, wash off after 10min incr to 30min.

### Divalproex Dose as for sodium valproate.

### DMSA See succimer.

### Dobutamine <30kg: 15mg/kg in 50ml 0.9% saline with heparin

### 1u/ml at 1-4ml/hr (5-20mcg/kg/min) via CVC or periph IV; >30kg:

### 6mg/kg made up to 100ml with 0.9% saline with heparin 1u/ml at 5-

### 20ml/hr (5-20mcg/kg/min).

### Docetaxel Initially 75-100mg/m2 over 1hr IV every 3wk.

### Docosanol 10% cream: apply 5 times a day.

### Docusate sodium NOT/kg: 100mg (3-10yr), 120-240mg (>10yr)

### daily oral. Enema (5ml 18% + 155ml water): 30ml (newborn), 60ml

### (1-12mo), 60-120ml (>12mo) PR.

### Docusate sodium 50mg + sennoside 8mg, tab >12yr: 1-4 tab at

### night oral. See also bisacodyl; casanthranol; dantron. .

### Dofetilide 10mcg/kg (adult 500mcg) 12H oral, less if renal

### impairment or increased QTc interval.

### Dolasetron Cancer: 1.8mg/kg (adult 100mg) IV 30min before

### chemo, or 4mg/kg (adult 200mg) oral 1hr before chemo. Surgery:

### 1mg/kg (adult 50mg) oral at induction, or 0.25mg/kg (adult 12.5mg)

### IV postop.

### Domperidone Oral: 0.2-0.4mg/kg (adult 10-20mg) 4-8H. Rectal

### suppos: adult (NOT/kg) 30-60mg 4-8H.

### Donepezil Adult (NOT/kg): 5mg at night oral, incr to 10mg after

### 1mo if reqd.

### Dopamine <30kg: 15mg/kg in 50ml 5%dex-hep at 1-4ml/hr (5-

### 20mcg/kg/min) via CVC; >30kg: 6mg/kg made up to 100ml in

### 5%dex-hep at 5-20ml/hr (5-20mcg/kg/hr).

### Dopexamine IV infsn 0.5-6mcg/kg/min.

### Doripenem 10mg/kg (adult 500mg) 8H IV.

### Dornase alpha (deoxyribonuclease I) NOT/kg: usually 2.5mg

### (max 10mg) inhaled daily (5-21yr), 12-24H (>21yr).

### Dorzolamide 2% drops: 1 drop/eye 8-12H.

### Dorzolamide 2% + timolol 0 5%. 1 drop/eye 12H.

### Dothiepin 0.5-1mg/kg (adult 25-50mg) 8-12H oral.

### Doxacurium 50-80mcg/kg stat, then 5-10mcg/kg/dose IV.

### Doxapram 5mg/kg IV over 1hr, then 0.5-1mg/kg/hr for 1hr (max

### total dose 400mg).

### Doxazosin Usually 0.02-0.1mg/kg (adult 1-4mg) daily oral.

### Doxepin 0.2-2mg/kg (adult 10-100mg) 8H oral. 5% cream: apply

### x3-4/day.

### Doxercalciferol (1,25-OH D2 analogue) Initially 0.2mcg/kg (adult

### 10mcg) oral, or 0.08mcg/kg (adult 4mcg) IV, x3/wk at end of

### dialysis. Aim for blood iPTH 150-300pg/ml. .

### Doxorubicin 30mg/m2 IV over 15min wkly, or 30mg/m2 daily for 2-

### 3days every 3-4wk. Max total dose 480mg/m2 (300mg/m2 if

### mediastinal irradiation).

### Doxorubicin, liposomal Carcinoma: 50mg/m2 IV every 3wk.

### Kaposi: 20mg/m2 IV every 2wk.

### Doxycycline Over 8yr: 2mg/kg (adult 100mg) 12H for 2 doses, then

### daily oral. Severe: 2mg/kg 12H. Malaria proph: 2mg/kg (adult

### 100mg) daily oral.

### Doxycycline 30mg + 10mg slow release (Oracea) Rosacea in adults

### (NOT/kg): 1 tab daily oral.

### Doxylamine succinate 0.25-0.5mg/kg (adult 12.5-25mg) 8H oral.

### Hypnotic: 0.5-1mg/kg (adult 25-50mg).

### Dronabinol Initially 5mg/m2 2-4H (max 4-6 doses per day) oral,

### slow incr by 2.5mg/m2/dose to max 15mg/m2 4H.

### Droperidol Antiemetic: postop 0.02-0.05mg/kg (adult 1.25mg) 4-

### 6H IM or slow IV, chemother 0.02-0.1 (adult 1-5mg) 1-6H.

### Psychiatry, neuroleptanalg, IM or slow IV: 0.1 mg/kg (adult 2.5mg)

### stat, incr to max 0.3mg/kg (adult 15 mg) 4-6H. Psychiatry, oral: 0.1-

### 0.4mg/kg (a

### Drospirenone + ethinyloestradiol (3mg/30mcg) x 21 tab + 7 inert tab

### Contraceptn: 1 daily starting 1st day menstruatn.

### Drospirenone + ethinyloestradiol (3mg/20mcg, 3mg/ 30mcg) x 24

### tab, + 4 inert tab Contraception: 1 daily starting 1st day of

### menstruation.

### Drospirenone + oestradiol (0. 5mg/1mg, 2mg/1mg). Postmenopause

### (NOT/kg): 1 tab daily oral.

### Drotrecogin alfa (protein C), activated 24mcg/kg/hr for 96hr IV.

### Minor surgery: stop 2hr before, restart straight after. Major surgery:

### stop 2hr before, restart 12hr after.

### Duloxetine Adult, NOT/kg: 20-30mg 12H, or 60mg daily oral.

### Dutasteride Adult (NOT/kg): 0.5mg daily oral.

### Dyclonine hydrochloride See dyclocaine hydrochloride.

### Dydrogesterone 0.2mg/kg (adult 10mg) 12-24H oral.

### Dydrogesterone + oestradiol (5mg/1mg, 10/1, 10/2) Adult

### (NOT/kg). Postmenopausal: 1 tab daily oral.

### Dydrogesterone 10mg tab + oestradiol patch (40 or 80 mcg/24hr)

### Adult (NOT/kg). Postmenopausal: apply new patch every 3-4

### days, 1tab daily oral for last 14days of cycle. .

### Econazole nitrate Topical: 1% cream, powder or lotion 8-12H.

### Vaginal: 75mg cream or 150mg ovule twice daily.

### Ecothiopate iodide 0.03%, 0.06%, 0.125%, 0.25% soltn: usually

### 0.125% 1 drop/eye every 1-2 days at bedtime.

### Eculizumab 600mg IV over 35min wkly for 4wk, 900mg the next

### wk, then 900mg every 2wk.

### Edrophonium Test dose 20mcg/kg (adult 2mg), then 1min later

### 80mcg/kg (adult 8mg) IV. SVT: 0.15mg/kg (max 2mg) incr to max

### 0.75mg/kg (max 10mg) IV, with atropine if reqd.

### EDTA See sodium calciumedetate. .

### Efalizumab 0.7mg/kg stat, then 1mg/kg wkly SC.

### Efavirenz Daily oral 10-15kg 200mg, 15-20mg 250mg, 20-25 kg

### 300mg, 25-33kg 350mg, 33-40kg 400mg, >40kg 600mg.

### Efavirenz 600mg + emtricitabine 200mg + tenofovir disoproxil

### fumarate 300mg >18yr (NOT/kg) 1tab daily.

### Eflornithine 13.9% cream: apply 12H.

### Eformoterol Caps 12mg (NOT/kg): 1cap (5-12yr) or 1-2 caps

### (adult) inhaled 12H.

### Eletriptan Adult (NOT/kg): 20-40mg, repeat after 2hr if reqd

### (max 80mg/day).

### EMLA cream See lignocaine + prilocaine.

### Emedastine 0.5mg/ml soltn: 1 drop/eye 12H.

### Emtricitabine Adult (NOT/kg) 200mg daily oral.

### Emtricitabine + tenofovir disoproxil (as fumarate) 200mg/245mg

### tab, >18yr (NOT/kg): 1tab daily oral.

### Enalapril 0.1mg/kg (adult 2.5mg) daily oral, incr over 2wk if reqd to

### max 0.5mg/kg (adult 5-20mg) 12H.

### Enalaprilat Usually 0.025mg/kg (max 1.25mg) 6H IV, max

### 0.1mg/kg (max 5mg) 6H.

### Enfuvirtide Age >=6yr: 2mg/kg (max 90mg) 12H SC.

### Enoxacin 4-8mg/kg (adult 200-400mg) 12H oral.

### Enoxaparin (1mg=100u) 1.5mg/kg (<2mo), 1mg/kg (2mo-18yr),

### 40mg (adult) 12H SC (anti-Xa 0.5-1u/ml 4hr post dose).

### Prophylaxis: 0.75mg/kg 12H (<2mo), 0.5 mg/kg 12H (2mo-18yr),

### 20-40mg 2-12hr preop, then daily (adult) SC. Haemodialysis:

### 1mg/kg into arterial line at start 4hr sess

### Enoximone IV: 5-20mcg/kg/min. Oral: 1-3mg/kg (adult 50-150mg)

### 8H.

### Entacapone Adult (NOT/kg): 200mg with each l-dopa/DDC

### inhibitor dose (av 800-1400mg/day, max 2000mg) oral.

### Entecavir Hepatitis B (adult, NOT/kg): 0.5mg daily oral; 1mg

### daily if refractory to lamivudine.

### Enzymes, pancreatic See pancreatic enzymes.

### Ephedrine 0.25-1mg/kg (adult 12.5-60mg) 4-8H oral, IM, SC, IV.

### Nasal (0.25%-1%): 1drop each nostril 6-8H, max 4 days.

### Epinastine 0.05% ophthalmic: 1 drop/eye 12H.

### Epinephrine See adrenaline.

### Epirubicin Adult: 75-90mg/m2 IV over 10min every 3wk.

### Eplerenone 0.5-1mg/kg (adult 25-50mg) 12-24H oral.

### Epoetin alfa, beta, delta 20-50u/kg x3/wk, incr to max 240 u/kg

### x1-3/wk SC, IV. When Hb >10g%: 20-100u/kg x2-3/wk.

### Epoprostenol (prostacyclin, PGI2) Incompatible with all other

### drugs. <8kg: 60mcg/kg in 50ml diluent at 0.25-0.75 ml/hr (5-

### 15ng/kg/min) via CVC or periph IV; >8kg: 500mcg in 50ml diluent at

### 0.03-0.09ml/kg/hr (5-15ng/kg/min). Chronic pul ht: 2ng/kg/min IV,

### incr to 20-40ng/kg/min. .

### Eprosartan 12mg/kg (adult 600mg) daily, incr if reqd to 6-8mg/kg

### (adult 300-400mg) 12H oral.

### Epsilon aminocaproic acid See aminocaproic acid.

### Eptacog alfa (recombinant factor 7a) See factor 7a.

### Eptifibatide Adult (NOT/kg): 180mcg/kg stat IV, then 2 mcg/kg/min

### for up to 72hr.

### Edosteine Adult (NOT/kg): 300mg 12H oral.

### Ergocalciferol (Vitamin D2) 40u = 1mcg = 1mcg cholecalciferol (D3).

### Cystic fib, cholestasis: 10-20mcg daily oral. Cirrhosis: adult 40-

### 120mcg daily oral. Deficiency: 50-100mcg daily for 2wk oral, then

### 10-625mcg daily (more if severe malabs); or 2.5-5mg (100,000-

### 200,000u) every 6-8wk.

### Ergoloid mesylates See co-dergocrine mesylate.

### Ergometrine maleate Adult (NOT/kg): 250-500mcg IM or IV;

### 500mcg 8H oral, sublingual or PR.

### Ergometrine maleate 0. 5mg + oxytocin 5u in 1ml. 1ml IM; may

### repeat after 2hr, max 3 doses in 24hr.

### Ergonovine maleate See ergometrine maleate.

### Ergotamine tartrate >10yr (NOT/kg): 2mg sublingual stat, then

### 1mg/hr (max 6mg/episode, 10mg/wk). Suppos (1-2mg): 1 stat, may

### repeat once after 1hr.

### Erlotinib Adult (NOT/kg): 150 mg daily oral; reduce to 100mg then

### 50mg daily if reqd.

### Ertapenem 20-40mg/kg (adult 1g) daily IM, IV over 30min.

### Erythromycin Oral or slow IV (max 5mg/kg/hr): usually 10 mg/kg

### (adult 250-500mg) 6H; severe inftn 15-25mg/kg (adult 0.75-1g) 6H.

### Gut prokinetic: 2mg/kg 8H. 2% gel: apply 12H.

### Escitalopram Adult (NOT/kg): 5mg daily oral, incr if reqd to max

### 20mg daily.

### Esmolol 0.5mg/kg (500mcg/kg) IV over 1min, repeated if reqd.

### Infsn (undiluted 10mg/ml soltn): 0.15-1.8ml/kg/hr (25-

### 300mcg/kg/min); rarely given for >48hr.

### Esomeprazole 0.4-0.8mg/kg (adult 20-40mg) daily oral. H.pylori

### (adult NOT/kg): 20mg + amoxycillin 1g + clarithromycin 500mg 12H

### oral for 7 days.

### Estazolam 0.02-0.1mg/kg (adult 1-4mg) at night oral.

### Estradiol See oestradiol.

### Estramustine 200mg/m2 8H oral (avoid milk).

### Eszopiclone Adult (NOT/kg): 2mg (1-3mg) at night oral.

### Etamsylate 12.5mg/kg (adult 500mg) 6H oral.

### Etanercept 0.4mg/kg (max 25mg) twice wkly deep SC.

### Ethacrynic acid IV: 0.5-1mg/kg (adult 25-50mg) 12-24H. Oral: 1-

### 4mg/kg (adult 50-200mg) 12-24H.

### Ethambutol hydrochloride 25mg/kg once daily for 8wk, then

### 15mg/kg daily oral. Intermittent: 35mg/kg x3/wk. IV: 80% oral dose.

### Ethamsylate 12.5mg/kg (max 500mg) 6H oral,IM,IV.

### Ethanol, dehydrated (100%) Vessel sclerosis: inject max of

### 1ml/kg.

### Ethanolamine oleate 5% soltn, adult (NOT/kg): 1.5-5ml per varix

### (max 20ml per treatment).

### Ethchlorvynol 10-20mg/kg (adult 0.5-1g) at night oral.

### Ethinyloestradiol 10-50mcg daily for 21 days per month. See also

### cyproterone; desogestrel.

### Ethinyloestradiol + ethynodiol diacetate (50mcg/0. 5mg or

### 50mcg/1mg) x 21 tab, + 7 inert tab. Contraception: 1 tab daily,

### starting 1st day of menstruation.

### Ethinyloestradiol + gestodene (30mcg/75mcg, 20/75) x 21 tab + 7

### inert tab 1 daily, starting 1st day of menstruation.

### Ethinyloestradiol + gestodene (30mcg/50mcg x 6 tab + 40/70 x5 +

### 30/100 x10 + inert x7) 1 tab daily, starting 1st day of menstruation.

### Ethinyloestradiol + levonorgestrel (100mcg/0 5mg). Post-coital: first

### dose within 72hr, repeated after 12hr.

### Ethinyloestradiol + levonorgestrel (20mcg/90mcg) Contraception: 1

### tab daily (with no hormone-free interval).

### Ethinyloestradiol + levonorgestrel (30mcg/150mcg or

### 50mcg/125mcg) x 21 tab, + 7 inert tab Contraception: 1 tab daily,

### starting 1st day of menstruation.

### Ethinyloestradiol + levonorgestrel (30mcg/50mcg x6tab + 40/75 x5

### \+ 30/125 x10 + inert x7) 1 tab daily, starting 1st day of

### menstruation.

### Ethinyloestradiol + levonorgestrel (30mcg/150mcg) x 84 tab, then

### either 7 inert tab or 7 tab ethinyloestradol 10 mcg Contraception: 1

### daily, starting 1st day menstruation.

### Ethionamide TB: 15-20mg/kg (max 1g) at night oral. Leprosy: 5-

### 8mg/kg (max 375mg) daily.

### Ethoheptazine 3mg/kg (adult 150mg) 6-8H oral.

### Ethosuximide 10mg/kg (adult 500mg) daily oral, incr by 50%

### each wk to max 40mg/kg (adult 2g) daily. Trough level 0.3-

### 0.7mmol/L.

### Ethotoin 5mg/kg (adult 250mg) 6H oral, incr to max 15mg/kg (adult

### 750mg) 6H.

### Ethynodiol See ethinyloestradiol + ethynodiol diacetate.

### Etidocaine 0.5%-1.5% soltn: max 6mg/kg (0.6ml/kg of 1%)

### parenteral, or 8mg/kg (0.8ml/kg of 1%) with adrenaline.

### Etidronate 5-20mg/kg daily oral (no food for 2hr before and after

### dose) for max 6mo. IV: 7.5mg/kg daily for 3-7 days.

### Etidonate and calcium citrate Etidronate 400mg tab daily 14 days,

### then calcium citrate 500mg daily for 76 days oral.

### Etodolac 4-8mg/kg (adult 200-400mg) 6-8H oral.

### Etomidate 0.3mg/kg slow IV. .

### Etonogestrel 68mg sub-dermal implant lasts 3yr.

### Etoposide 50-60mg/m2 IV over 1hr daily for 5 days, repeat after

### 2-4wk. Oral dose 2-3 times IV dose.

### Etoricoxib Adult (NOT/kg). 60-90mg daily oral. Gout: 120 mg

### daily, max 8 dyas.

### Etretinate 0.25mg/kg 8-12H oral for 2-4wk, then 6H (max 75mg

### daily) if reqd for 6-8wk, then 12-24H.

### Etynodiol diacetate Contraception: 500mcg daily oral, starting

### 1st day of menstruation.

### Everolimus Adult (NOT/kg): 0.75mg 12H oral adjusted to trough

### level 3-8ng/ml (chromatographic assay).

### Exemestane Adult (NOT/kg): 25mg daily oral.

### Exenatide Adult, NOT/kg: 5mcg SC before morning and evening

### meals, incr if reqd to 10mcg/dose after 1mo.

### Ezetimibe Adult (NOT/kg): 10mg daily oral.

### Factor 7a, recombinant (rFVIIa) Usually 90mcg/kg IV 2H until

### haemostasis, then 3-6H.

### Factor 8 concentrate (vial 200-250u), recombinant antihaemophilic

### factor (rAHF) Joint 20u/kg, psoas 30u/kg, cerebral 50u/kg. 2 x

### dose(u/kg) = % normal activity, eg 35u/kg gives peak level of 70%

### normal.

### Factor 8 inhibitor bypassing fraction IV max 2u/kg/min: joint 50u/kg

### 12H, mucous mem 50u/kg 6H, soft tissue 100u/kg 12H, cerebral

### 100u/kg 6-12H.

### Factor 9 IV infsn (max 2u/kg/min): minor hge 25u/kg daily, joint

### 40u/kg 12-24H, surgery 50u/kg stat then 30u/kg 12-24H, major

### surgery 85u/kg stat then 50u/kg 12-24H. Prophylaxis: 25-40u/kg

### x2/wk (trough >1u/dl). .

### Factor 9 complex (factor 2, 9, 10, and some 7) 40-60 iu/kg, then

### 5-10iu/kg 12H IV. Prophylaxis: 10-20iu/kg x1-2/wk. Factor 8

### antibodies: 75iu/kg, repeat in 12hr prn.

### Factor 13 Vial 250u. Prophylaxis: 10u/kg IV every 4wk. Pre-op:

### up to 3u/kg just before surgery, then 10u/kg daily x5. Severe hge:

### 10-20u/kg daily.

### Famciclovir Zoster, varicella: 5mg/kg (adult 250mg) 8H oral for 7

### days; immunocompromised 10mg/kg (adult 500mg) 8H for 10 days.

### Genital herpes (adult, NOT/kg): 125mg 12H oral for 5 days (treat),

### 250mg (suppress) 12H; immunocompromised 500mg 12H for 7

### days (treat), 50

### Famotidine 0.5-1mg/kg (adult 20-40mg) 12-24H oral. 0.5mg/kg

### (max 20mg) 12H slow IV.

### Fat emulsion 20% See lipid emulsion.

### Felbamate 5mg/kg 6-8H (max 1200mg/day) oral, incr over 2-3wk

### to 15mg/kg 6-8H (max 3600mg/day).

### Felodipine 0.1mg/kg (adult 2.5mg) daily, incr if reqd to 0.5 mg/kg

### (adult 10mg) daily oral.

### Fenbufen 10mg/kg (adult 450mg) 12H oral.

### Fenfluramine Adult (NOT/kg): 60mg daily oral.

### Fenofibrate 2mg/kg (adult 100mg) 6-12H oral.

### Fenoldopam 0.1mcg/kg/min IV infsn incr gradually if reqd every 15-

### 30min to max 1.6mcg/kg/min.

### Fenoprofen 4mg/kg (adult 200mg) 6-8H oral, may incr gradually to

### 12mg/kg/dose (max 800mg).

### Fenoterol Oral: 0.1mg/kg 6H. Resp soltn 1mg/ml: 0.5ml diluted

### to 2ml 3-6H (mild), 1ml diluted to 2ml 1-2H (moderate), undiluted

### continuous (severe, in ICU). Aerosol (200mcg/puff): 1-2 puffs 4-8H.

### Fentanyl Not ventltd: 1-2 mcg/kg (adult 50-100mcg) IM or IV; infsn

### 2-4mcg/kg/hr (<10kg 100mcg/kg in 50ml 5%dex-hep at 1-2ml/hr;

### >10kg amp 50mcg/ml at 0.04-0.08ml/kg/hr). Ventilated: 5-10mcg/kg

### stat or 50mcg/kg IV over 1hr; infuse amp 50mcg/ml at 0.1-

### 0.2ml/kg/hr (5

### Fenticonazole vaginal pessaries 600mg nocte once, or 200mg

### nocte for 3 nights.

### Ferrous salts Prophylaxis 2mg/kg/day elemental iron oral, treatment

### 6mg/kg/day elemental iron oral. Fumarate 1mg = 0.33mg iron.

### Gluconate 1mg = 0.12mg iron; so Fergon (60 mg/ml gluconate)

### prophylaxis 0.3ml/kg daily, treatment 1ml/kg daily oral. Sulphate

### (dry) 1mg = 0.3

### Fexofenadine NOT/kg: 30mg 12H (6-11yr), 60mg 12H or

### 180mg daily (>11yr) oral.

### Fibrinolysin 8-10u/ml + desoxyribonuclease 500-667 u/ml

### Ointment or soltn: apply topically 6-24H.

### Filgrastim (granulocyte CSF) Idiopathic or cyclic neutropaenia:

### 5mcg/kg daily SC or IV over 30min. Cong neutropaenia: 12mcg/kg

### daily SC or IV over 1hr. Marrow trans: 20-30mcg/kg daily IV over 4-

### 24hr, reduce if neutrophil >1x109/L.

### Finasteride Adult (NOT/kg). Prostatic hyperplasia: 5mg daily oral.

### Alopecia: 1mg daily oral.

### Flavoxate 2-4mg/kg (adult 100-200mg) 6-8H, or single dose at

### bedtime oral.

### Flecainide 2-3mg/kg (max 100mg) 12H oral, may incr over 2wk

### to 7mg/kg (max 200mg) 8-12H. IV over 30min: 0.5-2mg/kg (max

### 150mg) 12H.

### Floxuridine (FUDR) 100-300mcg/kg/day by constant intra-arterial

### infsn (400-600mcg/kg/day in hepatic artery). Stop if WCC

### <3500/mm3 or platelets <100,000/mm3.

### Flucloxacillin Oral: 12.5-25mg/kg (adult 250-500mg) 6H. IM or IV:

### 25mg/kg (adult 1g) 6H. Severe inftn: 50mg/kg (adult 2g) IV 12H (1st

### wk life), 8H (2-4 wk), 6H or constant infsn (>4 wk). See also

### ampicillin + flucloxacillin.

### Fluconazole 6mg/kg (adult 200mg) stat, then 3mg/kg (adult

### 100mg) daily oral or IV. Severe inftn: 12mg/kg (adult 400mg) stat,

### then 6-12mg/kg (adult 200-400mg) daily IV; if haemofiltered

### 12mg/kg (adult 600mg) 12H.

### Flucytosine (5-fluorocytosine) 400-1200mg/m2 (max 2g) 6H IV

### over 30 min, or oral. Peak level 50-100mcg/ml, trough 25-50mcg/ml

### (x7.75=umol/L).

### Fludarabine 25mg/m2 daily x5 IV over 30min, every 28 days.

### Fludrocortisone acetate 150mcg/m2 daily oral. Fludrocortisone

### 1mg = hydrocortisone 125mg in mineralocorticoid activity, 10mg in

### glucocorticoid.

### Flumazenil 5mcg/kg every 60sec to max total 40mcg/kg (adult

### 2mg), then 2-10mcg/kg/hr IV.

### Flunisolide Asthma (250mcg/puff): 1-2 puffs 12H. Nasal

### (25mcg/puff): 1-2 puffs/nostril 8-24H.

### Flunitrazepam Adult (NOT/kg): 0.5-2mg at night, oral.

### Fluocinonide 0.025%, 0.05% cream or oint: apply 6-12H.

### Fluocortolone 0.25% cream, ointment: apply 8-12H.

### Fluorescein 1%, 2% drops: 1 drop/eye. 10% (100 mg/ml), 25%

### (250mg/ml): 8mg/kg (max 500mg) IV.

### 9-alpha-fluorohydrocortisone See fludrocortisone.

### Fluorouracil 15mg/kg (max 1g) IV over 4hr daily until side effects,

### then 5-10mg/kg wkly. See also adrenaline + fluorouracil; and folinic

### acid.

### Fluoxetine 0.5mg/kg (max 20mg) daily, incr to max 1mg/kg (max

### 40mg) 12H oral. Weekly 90mg cap: 1 per wk.

### Fluoxetine + olanzapine (25mg/6mg, 25mg/12mg, 50mg/6mg,

### 50mg/12mg) Adult (NOT/kg): 1cap daily oral.

### Fluoxymesterone 0.1-0.2mg/kg (adult 5-10mg) daily oral.

### Flupenthixol Oral: 0.05-0.2mg/kg (adult 3-9mg) 12H. Depot IM:

### usually 0.4-0.8mg/kg (up to 5mg/kg, max 300 mg) every 2-4wk

### (1mg flupenthixol deconate = 0.625mg fluphenazine decanoate =

### 1.25mg haloperidol).

### Fluphenazine 0.02-0.2mg/kg (adult 1-10mg) 8-12H oral.

### Flurandrenolide See flurandrenolone.

### Flurandrenolone 0.025%, 0.05% cream, ointment or lotion: apply

### 6-24H. 4mcg/m2 tape: apply 12H.

### Flurazepam Adult (NOT/kg): 15-30mg at night, oral.

### Flurbiprofen 1-2mg/kg (adult 50-100mg) 8H oral or PR. 0.03%

### drops: 1 drop/eye every 30min x4 doses.

### Flutamide Adult (NOT/kg): 250mg 8H oral.

### Fluticasone Inhaled (NOT/kg): 50-100mcg (child), 100-500mcg

### (adult) 12H. 0.05% soltn: 1-4 sprays /nostril daily. 0.05% cream:

### apply sparingly daily.

### Fluticasone + salmeterol NOT/kg. Accuhaler: 100mcg/ 50mcg

### (child), 250/50 or 500/50 (adult) x1-2 inhltn 12H. MDI: 50/25 (child),

### 125/25 or 250/25 x1-2 inhltn 12H.

### Fluvastatin 0.4mg/kg (adult 20mg) nocte oral, incr to 0.8 mg/kg

### (adult 40mg) 12H if reqd. Slow relse: 80mg nocte.

### Fluvoxamine 2mg/kg (adult 100mg) 8-24H oral.

### Folic acid NOT/kg. Deficiency: 50mcg (neonate), 0.1-0.25mg

### (<4yr), 0.5-1mg (>4yr) daily IV, IM, SC or oral. Metabolic dis:

### 5mg/day oral. Pregnancy: 0.5mg (high risk 4mg) daily oral.

### Folinic acid See calcium folinate.

### Follicle stimulating hormone (FSH) Adult (NOT/kg), monitor urinary

### oestrogen. Anovulation: usually 50-150iu SC daily for 9-12 days.

### Superovulation (2wk after starting GnRH agonist): 100-225iu/kg

### daily starting day 3 of cycle.

### Follitropin alpha, beta See follicle stimulating hormone.

### Fomivirsen Intravitreal injection, adult (NOT/kg). New disease:

### 165mcg/eye wkly x3, then every 2wk. Previously treated:

### 330mcg/eye stat, in 2wk, then every 4wk. .

### Fondaparinux See fondaparin.

### Fondaparin Adult (NOT/kg): 2.5mg SC 6hr postop, then daily for

### 5-9 days.

### Formestane Adult (NOT/kg): 250mg 2wkly deep IM.

### Formoterol >4yr (NOT/kg). Powder: 12mcg inhalation 12H.

### Solutn: 20mcg in 2ml nebulised 12H. See also budesonide.

### Fosamprenavir Adult (NOT/kg): 0.7g 12H, or 1.4g daily oral.

### Foscarnet 20mg/kg IV over 30min, then 200mg/kg/day by

### constant IV infsn (less if creatinine >0.11mmol/l) or 60 mg/kg 8H IV

### over 2hr. Chronic use: 90-120mg/kg IV over 2hr daily.

### Fosfestrol Adult (NOT/kg). Initial: 0.5g IV over 1hr day 1, then 1g

### x5 days. Maintenance: 120-240mg 8H oral, later reducing to 120-

### 240mg daily.

### Fosfomycin tromethamine One 5.63g (3g base) sachet mixed with

### water once oral. .

### Fosinopril 0.2-0.8mg/kg (adult 10-40mg) daily oral.

### Fosphenytoin 75mg = 50mg phenytoin (qv). Prescribed and

### dispensed as phenytoin equivalents.

### Fotemustine IV over 1hr, or IA over 4hr: 100mg/m2 weekly x3, rest

### 4-5wk, then every 3wk.

### Framycetin sulfate (Soframycin) Subconjunctival: 500mg in 1ml

### water daily x3 days. Bladder: 500mg in 50ml saline 8H x10 days.

### 0.5%: eye 1drop 8H, ear 3drops 8H, ointment 8H.

### Framycetin sulfate 15mg/g + gramicidin 0. 05mg/g. Cream or

### ointment (Soframycin topical): apply 8-12H. See also

### dexamethasone + framycetin + gramicidin.

### Fresh frozen plasma Contains all clotting factors. 10-20 ml/kg IV.

### 1 bag is about 230ml.

### Frovatriptan Adult (NOT/kg): 2.5mg oral (max 7.5mg/day).

### Frusemide Usually 0.5-1mg/kg (adult 20-40mg) 6-24H (daily if

### preterm) oral, IM, or IV over 20min (max 0.05 mg/kg/min IV). IV

### infsn: 0.1-1mg/kg/hr (<20kg 25 mg/kg in 50ml 0.9% saline with

### heparin 1u/ml at 0.2-2 ml/hr; >20kg amp 10mg/ml at 0.01-

### 0.1ml/kg/hr); protect

### Fulvestrant Adult (NOT/kg): 250mg IM once a month.

### Furazolidone 2mg/kg (adult 100mg) 6H oral 7-10day.

### Fusafungine 125mcg spray: oral 1spray/10kg (adult 5 sprays)

### x5/day, nasal 1spray/20kg (adult 3sprays) x5/day.

### Fusidate, sodium See sodium fusidate.

### Fusidic acid Fusidic acid (susp) absorption only 70% that of

### sodium fusidate (tabs). Suspension: 15-20mg/kg (adult 750mg) 8H

### oral. Eye %: 1drop/eye 12H. For tablets and IV, see sodium

### fusidate.

### Gabapentin Anticonvulsant: 10mg/kg (adult 300mg) once day 1

### oral, 12H day 2, 8H day 3 then adjusted to 10-20 mg/kg (adult 300-

### 1200mg) 8H. Premed: 25mg/kg (adult 1200mg) 1hr preop.

### Analgesia: 2mg/kg (adult 100mg) 8H, incr if reqd to 15mg/kg (adult

### 800mg) or higher if

### Galantamine Adult (NOT/kg): 4mg 12H for 4wk, then 8mg 12H, incr

### after 4wk if reqd to 8-12mg 12H oral.

### Gallamine 1-2mg/kg (adult 50-100mg) IV.

### Gallium nitrate 100-200mg/m2/day x5days constant IV infsn.

### Gamma benzene hexachloride See lindane.

### Gamma globulin See immunoglobulin.

### Gamma hydroxybutyrate See sodium oxybate .

### Gamolenic acid 2-5mg/kg (adult 120-240mg) 12H oral.

### Ganciclovir 5mg/kg 12H IV over 1hr for 2-3wk; then 5mg/kg IV

### daily, or 6mg/kg IV on 6 days/wk, or 20 mg/kg (adult 1g) 8H oral.

### Congenital CMV: 7.5mg/kg 12H IV over 2hr.

### Ganirelix Adult (NOT/kg): 0.25mg daily SC from day 6 of FSH to day

### of ovulation induction.

### Gas gangrene (Clostridia) antitoxin Prophylaxis: 25,000u IM or IV.

### Treatment: 75,000-150,000u IV over 1hr, repeat x1-2 after 8-12hr; if

### severe also give 100,000u IM.

### Gatifloxacin 8mg/kg (adult 400mg) daily IV over 1hr. Gonorrh:

### 8mg/kg (adult 400mg) once. 0.3% ophthalmic: 1 drop/eye 2H when

### awake days 1-2, then x4/day days 3-7.

### Gaviscon See alginic acid.

### Gefitinib Adult (NOT/kg): 250mg daily oral.

### Gelatin, succinylated 10-20ml/kg (may be repeated). Volume

### effect lasts 3-4hr.

### Gemcitabine 1g/m2 IV over 30min wkly for 3wk, rest for 1wk, then

### repeat 4wk cycle.

### Gemeprost (PGE1 analogue) Cervical dilatation: 1 pessary (1mg)

### into posterior vagina 3hr before surgery. Termination: 1 pessary

### (1mg) into posterior vagina 3H (max 5 pessaries).

### Gemfibrozil 10mg/kg (max 600mg) 12H oral.

### Gemifloxacin Adult (NOT/kg): 320mg daily oral.

### Gemtuzumab ozogamicin 9mg/m2 IV over 2hr, repeated after 14

### days.

### Gentamicin IV or IM. 1wk-10yr: 8mg/kg day 1, then 6 mg/kg daily.

### >10yr: 7mg/kg day 1, then 5mg/kg (max 240-360mg) daily.

### Neonate, 5mg/kg dose: <1200g 48H (0-7 days of life), 36H (8-30

### days), 24H (>30 days); 1200-2500g 36H (0-7 days of life), 24H (>7

### days); term 24H

### Gentamicin, eye drops 0.3% 1drop/eye every 15min if severe,

### reducing to 1drop 4-6H.

### Gestodene See ethinyloestradiol + gestodene.

### Gestrinone Adult (NOT/kg): 2.5mg x2/wk on day 1 and 4 of

### menstrual cycle, then on same days each wk.

### Gestronol Adult (NOT/kg): 200-400mg every 5-7 days IM.

### Ginkgo biloba Adult (NOT/kg): 1200mg 12H oral.

### Glatiramer Adult (NOT/kg): 20mg daily SC.

### Glibenclamide Adult (NOT/kg): initially 2.5mg daily oral, max

### 20mg daily.

### Glibenclamide + metformin Adult (NOT/kg): 1.25mg/ 250mg 12-24H

### oral, incr if reqd to 2.5mg/500mg or 5mg/ 500mg (max

### 10mg/1000mg) 12H. .

### Gliclazide Adult (NOT/kg): initially 40mg daily oral, max 160mg

### 12H.

### Glimepiride Adult (NOT/kg): 2-4mg (max 6mg) daily oral.

### Glimepiride + pioglitazone (2mg/30mg, 4mg/30mg) Adult

### (NOT/kg): 1 tab daily oral.

### Glimepiride + rosiglitazone (1mg/4mg, 2mg/4mg, 4mg/ 4mg)

### Adult (NOT/kg): 1-2 tab daily (max 4mg/8mg) oral.

### Glipizide Adult (NOT/kg): 5mg daily oral, max 20mg 12H.

### Gliquidone 0.25-1mg/kg (adult 15-60mg) 8-12H oral.

### Glucagon 1u=1mg. 0.04mg/kg (adult 1-2mg) IV or IM stat, then

### 10-50mcg/kg/hr (0.5mg/kg in 50ml at 1-5ml/hr) IV. Beta-blocker

### overdose: 0.1mg/kg IV stat, then 0.3-2 mcg/kg/min.

### Glucose electrolyte solution Not dehydrated: 1 heaped teaspoon

### sucrose in large cup of water (4% sucrose = 2% glucose); do NOT

### add salt. Dehydrated: 1 sachet of Gastrolyte in 200ml water; give

### frequent sips, or infuse by NG tube.

### Glutamic acid 10-20mg/kg (adult 0.5-1g) oral with meals.

### Glyburide See glibenclamide.

### Glycerin See sorbolene + glycerin cream.

### Glycerol Suppos: 0.7-1g infant, 1.4-2g child, 2.8-4g adult.

### Glyceryl trinitrate Adult (NOT/kg): sublingual tab 0.3-0.9 mg/dose

### (lasts 30-60min); sublingual aerosol 0.4-0.8 mg/dose; slow-release

### buccal tab 1-10mg 8-12H; transdermal 0.5-5cm of 2% ointment, or

### 5-15mg patch 8-12H. IV infsn 0.5-5mcg/kg/min (<30kg 3mg/kg in

### 50ml 5%dex-hep

### Glycopyrrolate To reduce secretions or treat bradycardia: 5-

### 10mcg/kg (adult 0.2-0.4mg) 6-8H IV or IM. With 0.05mg/kg

### neostigmine: 10-15mcg/kg IV. Anticholinergic: 0.02-0.04mg/kg

### (max 2mg) 8H oral.

### Glycopyrronium bromide Dose as for glycopyrrolate.

### GM-CSF See sargramostim.

### Gold sodium thiomalate See sodium aurothiomalate.

### Gonadorelin (GnRH or LHRH) Pituitary function test, child or adult:

### 100mcg IV. See also leuprorelin.

### Gonadotrophin See chorionic gonadtrn, and menotrophin.

### Goserelin Adult (NOT/kg): 3.6mg SC every 28 days; implant

### 10.8mg SC every 12wk. See also bicalutamide.

### Granisetron 0.04mg/kg (adult 1mg) IV over 5min daily.

### Chemotherapy: 0.05mg/kg (adult max 1-3mg) IV over 5min; up to 3

### doses/day, at least 10min apart.

### Granulocyte-macrophage colony stimulating factor (GM-CSF) See

### lenograstim, sargramostim.

### Griseofulvin (Grisovin, Fulcin) 10-20mg/kg (adult 0.5-1g) daily

### oral.

### Griseofulvin, ultramicrosize (Griseostatin) 5.5-7mg/kg (adult

### 330-660mg) daily oral.

### Growth hormone See somatropin.

### Guaifenesin See guaiphenesin.

### Guaiphenesin 4-8mg/kg (adult 200-400mg) 4H oral.

### Guanabenz 0.1mg/kg (max 4mg) 12H oral, incr to max 0.6mg/kg

### (max 32mg) 12H.

### Guanadrel 0.1mg/kg (max 5mg) 12H oral, incr to max 0.5mg/kg

### (max 25mg) 8-12H.

### Guanethidine 0.2mg/kg (max 10mg) daily oral, incr to 0.5-6mg/kg

### (max 300mg) daily. Regnl symp block (adult): cuff 55mmHg >syst

### BP, 10-20mg in 10-25ml saline (arm) or 15-30mg in 15-50ml (leg)

### IV, wait 10-20min, release cuff over 5min; >=7 days between injctns

### (max 12/y

### Guanfacine 0.02mg/kg (max 1mg) daily oral, incr over several wks

### to max 0.06mg/kg (max 3mg) daily.

### Guar gum 1g/10kg (adult 5g) 8H oral in fluid 40ml/g gum. .

### Haem arginate 3-4mg/kg daily IV over 30-60min.

### Haemaccel See polygeline.

### Haemophilus influenzae type b, vaccines Inactivated. <12mo:

### give diphtheria protein conjugate (HibTITER, ProHIBiT), or tetanus

### conjugate (Act-HIB, Hiberix) 0.5ml IM at 2mo, 4mo, 6mo and 15mo;

### or meningococcal conjugate (Pedvax HIB) 0.5ml IM at 2mo, 4mo

### and 15mo. If 1st dose >18mo: give 1 dose o

### Haemophilus influenzae type b + hepatitis B vaccine (Comvax)

### Inactivated. 0.5ml IM 2mo, 4mo, 12-15mo (3 doses).

### Haemophilus influenzae type b + meningococcus type c vaccine

### (Menitorix) Inactivated. 0.5ml IM 2mo, 3mo, 4mo (3 doses); boost

### from 12mo.

### Halcinonide 0.1% cream: apply sparingly 8-12H.

### Halobetasol 0.05% cream, ointment: apply 12-24H.

### Halofantrine 10mg/kg (max 500mg) 6H for 3 doses oral, repeat

### after 1wk if nonimmune.

### Haloperidol 0.01mg/kg (max 0.5mg) daily, incr up to 0.1 mg/kg

### 12H IV or oral; up to 2mg/kg (max 100mg) 12H used rarely. Acutely

### disturbed: 0.1-0.2mg/kg (adult 5-10mg) IM. Long-acting decanoate

### ester: 1-6mg/kg IM every 4wk.

### Heparin 1mg=100u. Low dose: 75u/kg IV stat, then 500u/kg in

### 50ml 0.9% saline at 1-1.5ml/hr (10-15u/kg/hr) IV. Full dose: 75u/kg

### (adult 5000u) IV stat, then 500u/kg in 50ml saline at 2-4ml/hr (20-

### 40u/kg/hr)<12mo, 2-3ml/hr (20-30 u/kg/hr) child, 1.5-2ml/hr (15-

### 20u/

### Heparin calcium Low dose: 75u/kg SC 12H.

### Heparin, low molecular weight See certoparin, dalteparin,

### danaparoid, enoxaparin, nadroparin.

### Hepatitis A vaccine (Havrix) Inactivated. 0.5ml (child) or 1ml

### (adult) IM stat, and in 6-12mo (2doses). Boost every 5yr.

### Hepatitis A vaccine (VAQTA) Inactivated. 0.5ml (child) or 1ml

### (>17yr) IM stat, and after 6-18mo (2 doses).

### Hepatitis A + hepatitis B vaccine (Twinrix) Inactivated. 1-15yr

### 0.5ml, >15yr 1ml IM stat, after 1mo, and after 6mo (3 doses). Boost

### every 5yr.

### Hepatitis B vaccine (Engerix-B, HB Vax II) Inactivated. Engerix-B

### 10mcg/dose (<10yr), 20mcg (>9yr); HB Vax II 2.5mcg/dose (<10yr),

### 5mcg (10-19yr), 10mcg (>19yr), 40mcg (dialysis) IM stat, after 1mo,

### and after 6mo (3 doses). Boost every 5yr. See diphtheria and

### haemophilus vaccines.

### Herpes zoster vaccine (Zostavax) Live. Age 50yr or more: 0.65ml

### SC once. See also Immunoglobulin, zoster.

### Hetastarch 6% 10-20ml/kg IV.

### Hexachlorophane 3% emulsion. >12mo: apply 5ml, scrub for 3min.

### Hexamethylmelamine 150-260mg/m2 daily oral for 14-21

### consecutive days of a 28 day cycle.

### Hexamidine See chlorhexidine.

### Hexamine 20mg/kg (adult 1g) 6H oral.

### Hexetidine 0.1% soln: rinse/gargle 15ml (NOT/kg) 8-12H.

### Histamine phosphate 1mg/ml base: prick, puncture or scratch

### testing. 0.1mg/ml base: intradermal testing.

### Histrelin Usually 10mcg/kg daily SC.

### Homatropine 2%, 5% soltn: 1 drop/eye 4H.

### Hormone replacement therapy With uterus: sequential combined

### oestrogen (eg.oestradiol) and progestogen (eg. norethisterone) if

### perimenopausal; continuous combined therapy if postmenopausal.

### Without uterus: oestrogen.

### Human chorionic gonadotrophin Chorionic gonadotrophin.

### Human menopausal gonadotrophin See menotrophin.

### Human papillomavirus vaccine (Cervarix, Gardasil) Inactivated.

### Females 10-46yr, males 9-15yr: 0.5ml IM, in 1-2mo, and 6mo later

### (3 doses).

### Hyaluronic acid Gel 20mg/ml: 0.7-1.4ml injctd in wrinkles.

### Hyaluronidase Hypodermoclysis: add 1-1.5u/ml fluid. Local

### anaesthesia: add 50u/ml soltn.

### Hydralazine 0.1-0.2mg/kg (adult 5-10mg) stat IV or IM, then 4-

### 6mcg/kg/min (adult 200-300mcg/min) IV. Oral: 0.4 mg/kg (adult

### 20mg) 12H, slow incr to 1.5mg/kg (max 50mg) 6-8H.

### Hydrochloric acid Use soltn of 100mmol/L (0.1M = 0.1N =

### 100mEq/L); give IV by central line only. Alkalosis: dose(ml) = BE x

### Wt x 3 (give half this); maximum rate 2ml/kg/hr. Blocked central

### line: 1.5ml/lumen over 2-4hr.

### Hydrochlorothiazide 1-1.5mg/kg (adult 25-50mg) 12-24H.

### Hydrocodone 0.1-0.2mg/kg (max 10-15mg) 4-6H oral.

### Hydrocortisone Usually 0.5-2mg/kg (adult 25-50mg) 6-8H oral,

### reducing as tolerated. 0.5%, 1% cream, ointment: apply 6-12H. 1%

### cream + clioquinol: apply 8-24H. 10% rectal foam: 125mg/dose.

### 2.5% eye ointment: apply 6H.

### Hydrocortisone sodium succinate 2-4mg/kg 3-6H IM, IV reducing

### as tolerated. Physiological: 5mg/m2 6-8H oral; 0.2mg/kg 8H IM, IV.

### Physiological, stress: 1mg/kg 6H IM, IV.

### Hydrocortisone 1% + pramocaine 1% Cream, foam: apply 8-12H

### after defaecation.

### Hydroflumethiazide 0.5-2mg/kg (adult 25-100mg) 12-48H.

### Hydrogen peroxide 10 volume (3%). Mouthwash 1:2 parts water.

### Skin or ear disinfectant 1:1 part water.

### Hydromorphone Oral: 0.05-0.1mg/kg (adult 2-4mg) 4H. IM, SC:

### 0.02-0.05mg/kg (adult 1-2mg) 4-6H. Slow IV: 0.01-0.02mg/kg (adult

### 0.5-1mg) 4-6H. Palliative care: incr to 40-50mg/day (up to

### 500mg/day) oral in divided doses.

### Hydroquinone 4% cream: apply 12H.

### Hydrotalcite 20mg/kg (adult 1g) 6H oral.

### Hydroxocobalamin (Vit B12) 20mcg/kg (adult 1000mcg) IM daily

### for 7 days then wkly (treatment), then every 2-3mo (prophyl); IV

### dangerous in megaloblastic anaemia. Homocystinuria,

### methylmalonic acidur: 1mg daily IM; after response, some patients

### maintained on 1-10mg daily oral.

### Hydroxyapatite 20-40mg/kg (adult 1-2g) 8H oral.

### Hydroxycarbamide See hydroxyurea.

### Hydroxychloroquine sulphate Doses as sulphate. Malaria:

### 10mg/kg (max 600mg) daily for 3 days; prophylaxis 5mg/kg (max

### 300mg) once a wk oral. Arthritis, SLE: 3-6.5mg/kg (adult 200-

### 600mg) daily oral.

### Hydroxyethylrutosides 5mg/kg (adult 250mg) 6-8H for 3-4wk, then

### 12-24H; or 10mg/kg (adult 500mg) 12H for 3-4wk, then daily oral.

### Hydroxyprogesterone Adult (NOT/kg): 250-500mg/wk IM.

### Hydroxypropylcellulose 5mg insert: 1 in each eye daily.

### Hydroxyquinone 4% cream: apply 12H.

### Hydroxyurea 80mg/kg oral every 3rd day, or 20-30mg/kg daily.

### CNS tumors: 1.5-3g/m2 oral stat, in 2wk, then every 4-6wk. Sickle

### cell: 15mg/kg daily, incr by 5mg/kg every 12wk to max 35mg/kg

### daily.

### Hydroxyzine 0.5-2mg/kg (adult 25-100mg) 6-8H oral. 0.5-1mg/kg

### (adult 25-100mg) 4-6H if reqd IM.

### Hylan 8mg inj into knee wkly x3; max 6 doses in 6mo.

### Hyoscine hydrobromide (scopolamine hydrobromide) 6-8mcg/kg

### (adult 400-600mcg) 6-8H IV, IM, SC. Motion sickness 300mcg tab

### (NOT/kg): 0.25 tab (2-7yr), 0.5 tab (7-12yr), 1-2 tab (>12yr) 6-24H

### oral 30 min before, may repeat in 4hr. Transdermal (1.5mg patch):

### >10yr 1 every 72hr.

### Hyoscine methobromide (methscopolamine) 0.2mg/kg (adult 2.5-

### 5mg) 6H oral.

### Hyoscine butylbromide 0.5 mg/kg (adult 20-40mg) 6-8H IV, IM

### or oral.

### Hyoscyamine (L-atropine) 2-5mcg/kg (adult 100-300 mcg) 4-6H

### oral, sublingual, IM or IV.

### Ibandronate (ibandronic acid) Adult, NOT/kg. Hypercalcaemia: 2-

### 4mg IV over 2hr once. Osteoporosis: 2.5mg daily, or 150mg each

### month oral; or 3mg IV bolus evey 3mo.

### Ibuprofen 5-10mg/kg (adult 200-400mg) 4-8H oral. Arthritis:

### 10mg/kg (adult 400-800mg) 6-8H. Cystic fibrosis: 20-30mg/kg 12H.

### PDA: 10mg/kg stat, then 5mg/kg after 24 and 48 hr IV over 15min.

### Ibutilide 0.017mg/kg (max 1mg) IV over 10min, then wait 10min

### and repeat once if reqd.

### Ichthammol 1-10% cream, ointment. Apply 6-8H.

### Idarubicin 12mg/m2 IV over 15min daily for 3 days.

### Idebenone Adult (NOT/kg): 30mg 8H oral.

### Idoxuridine 0.1% eye drops: 1 drop every 15min for 2hr, then

### hourly by day and 2H at night. 0.1% soltn or 0.5% ointment: apply

### hourly first 24hr, then 4H.

### Ifosfamide Usually 1.2-2.0g/m2 IV over 4hr daily x5, or 5-6 g/m2

### (max 10g) IV over 24hr once. Repeat every 2-4wk.

### Iloprost Adult (NOT/kg): 2.5-5mcg x6-9/day by inhalation.

### Imatinib Adult (NOT/kg): 400mg daily (chronic CML), 600mg daily

### (blast crisis) or 400mg 12H (unresponsive blast) oral.

### Imidapril 0.1mg/kg (adult 5mg) daily oral, incr if reqd to 0.2-

### 0.3mg/kg (adult 10-20mg) daily.

### Imiglucerase Usual initial dose 60u/kg every 2wk IV over 2hr,

### adjusted according to response; reduce every 3-6mo.

### Imipenem (+ cilastatin) 15mg/kg (adult 500mg) 6H IV over

### 30min. Severe inftn: 25mg/kg IV over 1hr (adult 1g) 12H (1st wk

### life), 8H (2-4 wk), 6-8H or constant infsn (4+ wk). .

### Imipramine 0.5-1.5mg/kg (adult 25-75mg) 8H oral. Enuresis: 5-6yr

### 25mg, 7-10yr 50mg, >10yr 50-75mg nocte.

### Imiquimod 5% cream: apply x2-3/wk (max 16wk) before bed;

### wash off after 6-10hr. Molluscum: 0.2% cream x3/wk.

### Immunoglobulin See also antivenoms.

### Immunoglobulin, CMV 100-200mg/kg IV over 2hr. Transplant: daily

### for first 3 days, wkly x6, monthly x6.

### Immunoglobulin, diphtheria 250u IM once.

### Immunoglobulin, hepatitis B 400u IM within 5 days of needle

### stick, repeat in 30 days; 100u IM within 24hr birth to baby of Hep B

### carrier. .

### Immunoglobulin, antilymphocyte (thymocyte) Horse (Atgam): 10-

### 15mg/kg daily for 3-5 days IV over 4hr; occasionally up to 30mg/kg

### daily. Rabbit (ATG-Fresenius): 2.5-5mg/kg daily over 4-6hr IV.

### Immunoglobulin, normal, human Hypogammaglobulinaemia: 10-

### 15ml/kg of 6% soltn (600-900mg/kg) IV over 5-8hr, then 5-7.5 ml/kg

### (300-450mg/kg) over 3-4hr monthly; or 0.6ml/kg of 16% soltn

### (100mg/kg) every 2-4wk IM. Sepsis: 0.5g/kg IV over 4hr. Kawasaki,

### Guillain-Barre, ITP, myasth gravis,

### Immunoglobulin, rabies (Hyperab, Imogam) 20iu (0.133 ml)/kg IM

### once (half SC around wound), with rabies vaccine.

### Immunoglobulin, Rh (anti-D) 1ml (625iu, 125mcg) IM within 72hr

### of exposure. Large transfusion: 0.16ml (100iu, 20mcg) per ml RH

### positive red cells (maternal serum should be anti-D positive 24-48hr

### after injection).

### Immunoglobulin, respiratory syncytial virus 750mg/kg every

### month IV (50mg/ml: 1.5ml/kg/hr for 15min, 3ml/kg/hr for 15min,

### then 6ml/kg/hr).

### Immunoglobulin, subcutanoeus (SCIG) Multiply previous IV

### immunoglobulin dose by 1.37, and divide this into weekly doses.

### Usually 100-200mg/kg by SC infusion weekly.

### Immunoglobulin, tetanus (TIG) IM preparation, prophylaxis: 250-

### 500iu (1-2amp). IV preparation, treatment: 4000iu (100ml) at

### 0.04ml/kg/min for 30min, then 0.075 ml/kg/min IV; intrathecal

### usually 250iu.

### Immunoglobulin, zoster 1iu = approx 1.5mg. Within 96hr of

### exposure: 0-10kg 300mg, 11-30kg 600mg, >30kg 900mg IM.

### Indapamide 0.03-0.05mg/kg (adult 1.5-2.5mg) daily oral.

### Indinavir >28 days: 500mg/m2 (adult 800mg) 8H oral.

### Indocyanine green IV. Dye dilutn: 0.1mg/kg (adult 5mg). Pulsion

### monitor: 0.25-0.5mg/kg. Liver functn: 0.5mg/kg.

### Indomethacin 0.5-1mg/kg (adult 25-50mg) 8H (max 6H) oral or

### PR. PDA: 0.1mg/kg (<1kg) or 0.2mg/kg (>=1kg) day 1, then

### 0.1mg/kg daily days 2-7 oral or IV over 1hr. .

### Indoramin 0.5-1.5mg/kg (adult 25-75mg) 8-12H oral.

### Infliximab 3mg/kg (arthritis, with methotrexate) 5mg/kg (Crohn's)

### IV over 2hr, then (if response) after 2wk, 6wk, and then 5-10mg/kg

### every 8wk.

### Influenza A and B vaccine (Fluvax, Vaxigrip) Inactivated. 0.125ml

### (3mo-2yr), 0.25ml (2-6yr), 0.5ml (>6yr) SC stat and 4wk later (2

### doses). Boost annually (1 dose).

### Influenza A and B live nasal vaccine (Flumist) >5yr: 0.25

### ml/nostril; repeat after 6wk if aged 5-8yr and previously

### unimmunised. Boost annually (1 dose).

### Inosine acedoben dimepranol Herpes, genital warts: 20 mg/kg

### (adult 1g) 6-8H oral. SSPE: 10-15mg/kg 4H oral.

### Inositol nicotinate 20mg/kg (adult 1g) 6-8H oral.

### Insulin Regular insulin IV: 0.025-0.1u/kg prn, or 0.025-0.1 u/kg/hr

### (2.5u/kg in 50ml 4% albumin at 0.5-2ml/hr); later 1u/10g dextrose.

### For hyperkalaemia: 0.1u/kg insulin and 2ml/kg 50% dextrose IV. In

### TPN: 5-25u/250g dextrose. SC insulin (onset/peak/duration): gl

### Insulin (Exubera) Initially 30-39kg 1mg, 40-59kg 2mg, 60-79kg

### 3mg, 80-99kg 4mg, inhaled 10min before meal.

### Interferon alfa-2a, recombinant Haemangioma: 1 million u/m2 daily

### SC or IM incr over 4wk to 2-3 million u/m2 daily for 16-24wk, then

### x3/wk. Hep B, C: 3-6 million u/m2 x3/wk SC or IM for 4-6mo; higher

### doses may be reqd in hep B.

### Interferon alfa-2b, recombinant Condylomata: 1 million unit into

### each lesion (max 5) x3/wk for 5wk. Haemangioma: as for interferon

### alfa-2a. Hep B: monotherapy as for interferon alfa-2a. Hep C (adult,

### NOT/kg) 3 million unit x3/wk SC, plus ribavirin 1000mg (1200mg if

### >75kg) daily oral, fo

### Interferon alfa-2a / alfa-2b, pegylated See peginterferon.

### Interferon alfa-n3 Warts (NOT/kg): 250,000u injected into base of

### wart (max 10 doses/session) x2/wk for max 8wk.

### Interferon alfacon-1 Hepatitis C (adult, NOT/kg): usually 9mcg

### (7.5mcg if not tolerated) x3/wk SC for 24wk; if relapse 15mcg x3/wk

### SC for 6mo.

### Interferon beta-1a Mult scler (adult, NOT/kg): Avonex 30mcg (6

### million IU) once a wk IM, Rebif 44mcg x3/wk SC.

### Interferon beta-1b Mult scler (adult, NOT/kg): 250mcg (8 million IU)

### SC alternate days.

### Interferon gamma-1b Chronic gran dis: 1.5mcg/kg (body area

### <=0.5m2) or 50mcg/m2 (area >0.5m2) x3/wk SC.

### Interleukin-2 See aldesleukin.

### Ipratropium bromide Resp soltn (250mcg/ml): 0.25-1ml diluted to

### 4ml 4-8H; severe attack every 20min for 3 doses, then 4-6H.

### Aerosol 20mcg/puff: 2-4 puffs 6-8H. Nasal: 84mcg/nostril 6-12H.

### Irbesartan 3mg/kg (adult 150mg) daily oral, incr to 6mg/kg (adult

### 300mg) daily if reqd.

### Irinotecan 350mg/m2 IV over 90min every 3wk; reduce to 250-

### 300mg/m2 every 3wk if toxicity.

### Iron See ferrous gluconate, ferrous sulphate.

### Iron dextran, iron polymaltose Fe 50mg/ml: dose (ml) = 0.05 x Wt

### in kg x (15 - Hb in g%) IM (often in divided doses). IV infsn possible

### (but dangerous).

### Isoconazole 1% cream 12H. Vaginal: 600mg (2 tab) once.

### Isoetharine Inhaltn soltn (1%): 0.5ml diltd to 4ml 3-6H (mild), 1ml

### diltd to 4ml 1-2H (moderate), undiltd constant (severe, in ICU).

### Aerosol 340mcg/puff: 1-2 puffs 4-6H.

### Isometheptene 2.5mg/kg (max 130mg) stat, then 1.5mg/kg (max

### 65mg) 1H to max 7mg/kg (max 325mg) in 12hr oral. See also

### dichloralphenazone.

### Isoniazid (INAH) 10mg/kg (max 300mg) daily oral, IM or IV. TB

### meningitis: 15-20mg/kg (max 500mg) daily.

### Isoniazid 50mg + pyrazinamide 300mg + rifampicin 120mg tab 30-

### 39kg x3, 40-49kg x4, 50-64kg x5, >65kg x6tab daily.

### Isoniazid + rifampicin 30-49kg 150mg/100mg tabs x3 daily, >50kg

### 300mg/150mg tabs x2 daily oral.

### Isoprenaline IV infsn: <33kg 0.3mg/kg in 50ml 5%dex-hep at 0.5-

### 10ml/hr (0.05-1mcg/kg/min); >33kg give 1/5000 (0.2 mg/ml) soltn at

### 0.015-0.15ml/kg/hr (0.05-0.5mcg/kg/min).

### Isoproterenol See isoprenaline.

### Isosorbide dinitrate Sublingual: 0.1-0.2mg/kg (max 10mg) 2H or

### as needed. Oral: 0.5-1mg/kg (max 40mg) 6H or as needed. Slow

### release tab, adult (NOT/kg): 20-80mg 12H. IV infsn 0.6-

### 2mcg/kg/min.

### Isosorbide mononitrate Slow release tab, adult (NOT/kg): 60-

### 120mg daily oral.

### Isotretinoin Adult: 0.5-1mg/kg daily oral for 2-4wk, reducing if

### possible to 0.1-0.2mg/kg daily for 15-20wk. 0.05% gel: apply

### sparingly at night.

### Isoxsuprine 0.2-0.5mg/kg (adult 10-20mg) 6-12H oral.

### Ispaghula husk Adult (NOT/kg): 1-2 x5ml teaspoonfuls 6-12H

### oral. Half this dose 6-12yr.

### Isradipine 0.05mg/kg 12H oral, may incr after 2-4wk gradually to

### 0.1-0.2mg/kg (max 10mg) 12H.

### Itraconazole 2-4mg/kg (adult 100-200mg) 12-24H oral after food.

### Trough level >0.5 mcg/ml at 10-14 days.

### Ivabradine 0.1mg/kg (adult 5mg) 12H oral, range 0.05-0.15

### mg/kg (adult 2.5-7.5mg) 12H. .

### Ivermectin 0.15-0.4mg/kg (adult 12-24mg) oral every 6-12 mo.

### Lice: 0.2mg/kg (adult 12mg) oral, repeat after 7 days.

### Ixabepilone 40mg/m2 IV over 3hr every 21 days for median of 4

### cycles. Vary dose with CYP3A4 inhibitors or inducers.

### Japanese encephalitis vaccine (Je-Vax) Inactivated. 0.5ml (1-3yr),

### 1ml (>3yr) SC stat, 7-14 days later, and (optionally) 1mo later.

### Boost after 1yr.

### Kanamycin Single daily dose IV or IM. Neonate: 15mg/kg stat,

### then 7.5mg/kg (<30wk) 10mg/kg (30-35wk) 15mg/kg (term <1wk)

### daily. 1wk-10yr: 25mg/kg day 1, then 18mg/kg daily. >10yr:

### 20mg/kg day 1, then 15mg/kg (max 1.5g) daily. Trough level

### <5.0mg/L.

### Ketamine Sedation, analgesia: 2-4mg/kg IM, 4mcg/kg/min IV.

### Premed: 5mg/kg oral. Anaesthesia: 5-10mg/kg IM, 1-2mg/kg IV,

### infsn 30mg/kg in 50ml 5%dex-hep at 1-4ml/hr (10-40mcg/kg/min).

### Incompatible with aminophylline, magnesium and salbutamol.

### Ketoconazole Oral: 5mg/kg (adult 200mg) 12-24H. 2% cream:

### apply 12-24H. 2% shampoo: wash hair, apply liquid for 5min, wash

### off.

### Ketoprofen 1-2mg/kg (adult 50-100mg) 6-12H (max 4mg/kg or

### 200mg in 24hr) oral, IM, PR. Slow release, adults (NOT/kg): 200mg

### daily.

### Ketorolac Oral: 0.2mg/kg (adult 10mg) 4-6H (max 0.8mg/kg/day

### or 40mg/day). IV or IM: usually 0.2mg/kg (adult 10mg) 6H; but may

### use 0.6mg/kg (max 30mg) stat, then 0.2-0.4mg/kg (max 20mg) 4-

### 6H for 5 days, then 0.2mg/kg (max 10mg) 6H. Eye drops 0.5%: 1

### drop 8H.

### Ketotifen Child >2yr (NOT/kg): 1mg 12H oral with food. Adult

### (NOT/kg): 1-2mg 12H oral with food.

### Labetalol Oral: 1-2mg/kg (adult 50-100mg) 12H, may incr wkly

### to max 10mg/kg (max 600mg) 6H. IV: 0.25-0.5mg/kg (adult 20mg)

### over 2min repeated every 10min if reqd, then 0.25-3mg/kg/hr.

### Lacidipine 0.04-0.12mg/kg (adult 2-6mg) daily oral.

### Lactase See tilactase.

### Lactulose 3.3g/5ml soltn. Laxative: 0.5ml/kg 12-24H oral.

### Hepatic coma: 1ml/kg hrly until bowel cleared, then 6-8H.

### Lamivudine Neonate <30 days: 2mg/kg 12H oral. Child >30 days:

### 4mg/kg 12H oral. Adult <50kg: 2mg/kg 12H oral. Adult >50kg:

### 150mg 12H or 300mg daily oral. Hepatitis b: 3-4 mg/kg (max

### 100mg) daily oral. See also abacavir.

### Lamivudine + zidovudine 150mg/300mg tab. >12yr (NOT/kg):

### 1tab 12H oral.

### Lamotrigine 0.2mg/kg (adult 25mg) oral daily, double dose every

### 2wk if reqd to max 1-4mg/kg (adult 50-200mg) 12H. Double dose if

### taking carbamazepine, phenobarbitone, phenytoin or primidone;

### halve dose if taking valproate.

### Lanreotide 0.5-1.0mg/kg (adult 30mg) IM every 2wk (adjust dose

### and frequency according to response).

### Lansoprazole 1.5mg/kg (max 30mg) 12-24H oral.

### Lanthanum carbonate Adult (NOT/kg) 0.5-1g 8H with meal.

### Lapatinib Adult, NOT/kg: 1.25g every day oral (plus

### capecitabine 2g/m2/day on days 1-14 of a repeating 21 day cycle).

### Laronidase 0.58mg/kg IV once a week.

### L-asparaginase See colaspase.

### Latanoprost 50mcg/ml: 1drop/eye daily.

### Laureth-9 Spider veins: inject 0.1-0.2ml of 0.5% (10mg /2ml).

### Small varices: 0.1-0.3ml of 1% (20mg/2ml). Medium varices: 0.5-

### 1ml of 3% (60mg/2ml). Max 2mg/kg/day.

### Leflunomide Adult (NOT/kg): 100mg daily x3, then 20mg daily oral.

### Lenalidomide Adult (NOT/kg): 10mg daily oral; or 25mg daily on

### days 1-21 of 28 day cycles.

### Lenograstim (rHuG-CSF, Granocyte) 150mcg/m2 daily SC or IV

### over 30min. Keep WCC 5,000-10,000/mm3.

### Lepirudin 0.4mg/kg IV stat, then 0.15mg/kg/hr (adjusted by

### APTT) for 2-10 days.

### Lercanidipine 0.2mg/kg (adult 10mg) daily oral, incr to 0.4mg/kg

### (adult 20mg) daily if reqd.

### Letrozole Adult (NOT/kg): 2.5mg daily oral.

### Leucovorin See folinic acid.

### Leuprorelin (GnRH or LHRH) Adult (NOT/kg): 7.5mg depot injn

### monthly IM; or microspheres 11.25mg SC every 3mo.

### Levalbuterol (levosalbutamol) See salbutamol.

### Levamisole Anthelmintic: 3mg/kg (adult 150mg) oral once

### (ascaris), repeat in 1wk (hookworm). Adenocarcinoma colon (with

### 5-fluorouracil 450mg/m2 IV wkly): 1mg/kg (adult 50mg) 8H oral for

### 3 days every 2wk.

### Levetiracetam 10mg/kg (adult 500mg) 12H oral, incr every 2-

### 4wk to max 30mg/kg (adult 1500mg) 12H if reqd.

### Levobetaxolol 0.5% soltn: 1drop/eye 12H.

### Levobupivacaine See bupivacaine.

### Levocabastine 0.5mg/ml: 1drop/eye 6-12H max 8wk, 2

### sprays/nostril 6-12H max 8wk.

### Levocarnitine See carnitine.

### Levocetirizine NOT/kg: 2.5mg (6-11yr) 5mg (adult) daily.

### Levodopa + benserazide (4:1) Adult (NOT/kg): initially levodopa

### 100mg 8H oral; if not controlled, incr wkly by 100mg/day to max

### 250mg 6H.

### Levodopa + carbidopa 250mg/25mg and 100mg/10mg tabs. Adult

### (NOT/kg): initially one 100/10 tab 8H oral; if not controlled,

### substitute one 250/25 tab for one 100/25 tab every 2nd day; if not

### controlled on 250/25 8H, incr by one 250/25 tab every 2nd day to

### max 6-8 tab/day.

### Levofloxacin 5-10mg/kg (adult 250-500mg) 12-24H oral or IV over

### 1hr. Eye 5mg/ml: 1drop x8/day for 2 days, then 6H.

### Levomepromazine See methotrimeprazine.

### Levomethadyl acetate Adult (NOT/kg): usual starting dose 20-40mg

### every 2-3 days oral.

### Levonorgestrel Contraception: 30mcg daily oral, starting 1st day

### menstruation. Intrauterine T-system 52mg: insert within 7 days of

### start of menstruation, replace after 3yr. Post-coital: 1.5mg oral

### within 72hr; or 0.75mg within 72hr, repeated after 12hr; or 0.5mg +

### ethin

### Levonorgestrel + oestradiol (7mcg/50mcg, 15mcg/45mcg per day)

### patch Post-menopausal (NOT/kg): 1 patch per wk.

### Levorphanol 0.03-0.1mg/kg 12-24H oral or SC.

### Levosimendan 0.3mg/kg (adult 0.15-0.3mg/kg) in 6ml/kg 5%dex

### (no heparin) and give 1.5ml/kg/hr for 10min (12.5mcg/kg), then

### 0.24ml/kg/hr (0.2mcg/kg/min; adult 0.1-0.2mcg/kg/min) for 24hr IV.

### Via CVC or peripheral IV; compatible only with frusemide or GTN. .

### Lidocaine See lignocaine.

### Lignocaine IV: 1% soltn 0.1ml/kg (1mg/kg) over 2min, then 0.09-

### 0.3ml/kg/hr (15-50mcg/kg/min); or 30mg/kg in 50ml 5%dex-hep at

### 50ml/hr for 2min, then 1.5-15ml/hr (15-50mcg/kg/min). Nerve block:

### without adrenaline max 4mg/kg (0.4ml/kg of 1%), with adrenaline

### 7mg/kg (0

### Lignocaine 2. 5% + prilocaine 2.5%. Cream (EMLA): 1.5g/10cm2

### under occlusive dressing for 1-3hr.

### Lincomycin 10mg/kg (adult 600mg) 8H oral, IM or IV over 1hr.

### Severe inftn: 15-20mg/kg (adult 1.2g) IV over 2hr 6H.

### Lindane 1% cream, lotion. Scabies: apply from neck down, wash

### off after 8-12hr. Lice: rub into hair for 4min, then wash off; repeat

### after 24hr (max x2/wk).

### Linezolid 10mg/kg 8-12H (child) or 400-600mg 12H (adult), IV over

### 1-2hr or oral.

### Linoleic acid See fatty acids.

### Liothyronine sodium (T3) Oral: 0.2mcg/kg (adult 10mcg) 8H, may

### incr to 0.4mcg/kg (adult 20mcg) 8H. IV: 0.1-0.4mcg/kg (adult 5-

### 20mcg) 8-12H. Septic shock: 0.1-0.2mcg/kg/hr (adult 100-

### 200mcg/day) IV infsn.

### Lipase, lipolytic enzymes See pancreatic enzymes.

### Lipid 20%: 1-3g/kg/day IV (ml/hr = g/kg/day x Wt x 0.21).

### Lisdexamphetamine dimesylate NOT/kg. 6-12yr: 30mg daily

### oral, incr over 2-3wk to max 70mg daily.

### Lisinopril 0.1mg/kg (adult 5mg) daily oral, may incr over 4-6wk to

### 0.2-1mg/kg (adult 10-20mg) daily.

### Lithium (salts) 5-20mg/kg 8-24H oral. Slow release tab 450mg

### (adult, NOT/kg): 1-2 tab 12H. Maintain trough level 0.8-1.6mmol/L

### (>2mmol/L toxic).

### Lodoxamide 0.1% soltn: 1 drop/eye 6H.

### Lofepramide Adult (NOT/kg): 70mg morning, 70-140mg night oral.

### Lofexidine 2-8mcg/kg (adult 100-400mcg) 6-12H oral.

### Lomefloxacin 8mg/kg (adult 400mg) daily oral.

### Lomustine (CCNU) 100-130mg/m2 oral every 6 wk.

### Loperamide 0.05-0.1mg/kg (adult 2-4mg) 8-12H oral, incr if reqd to

### max 0.4mg/kg (max 4mg) 8H.

### Lopinavir + ritonavir >2yr: 230/57.5 mg/m2 (max 400/100mg) 12H

### oral; with nevirapine or efavirenz 300/75mg/m2 (max 533/133mg)

### 12H.

### Loprazolam Adult (NOT/kg): 1mg (max 2mg) bedtime oral.

### Loracarbef 4-8mg/kg (adult 200-400mg) 12H oral.

### Loratadine NOT/kg: 5mg (2-5yr), 10mg (>5yr) daily oral.

### Lorazepam 0.02-0.06mg/kg (adult 1-3mg) 8-24H oral. IV: 0.05-

### 0.2mg/kg IV over 2min, then 0.01-0.1mg/kg/hr.

### Lormetazepam Adult (NOT/kg): 0.5mg (max 1.5mg) at bedtime

### oral.

### Losartan 0.5-2mg/kg (adult 25-100mg) daily oral.

### Lovastatin 0.4-0.8mg/kg (adult 20-40mg) 12-24H oral. Slow

### release (adult, NOT/kg): 10-60mg at bedtime. .

### Lovastatin + slow-release niacin (20/500mg, 20/750mg,

### 20/1000mg) 20mg/500mg at bedtime oral, incr if reqd every 4wk

### by 500mg niacin to max 40mg/2000mg.

### Loxapine 0.2-1mg/kg (adult 10-60mg) 6-12H oral, IM.

### Lubiprostone Adult (NOT/kg): 24mcg 12-24H oral with food.

### Lumefantrine (benflumetol) See artemether.

### Lumiracoxib Adult, NOT/kg: 100mg daily oral.

### Lutropin alfa (luteinising hormone Adult (NOT/kg): 75iu daily SC,

### with 75-150iu follicle stimulating hormone.

### Lyme disease vaccine Recombinant OspA. 30mcg in 0.5ml IM at 0,

### 1 and 12mo.

### Lymecycline 408mg = 300mg tetracycline base. Adult (NOT/kg):

### 408mg 12H oral.

### Lypressin (lysine-8-vasopressin) 1 spray (2.5iu) into 1 nostril 4-

### 8H, may incr to 1 spray both nostrils 4-8H.

### Lysuride Migraine: 0.5mcg/kg (adult 25mcg) 8H oral. Parkinson's,

### adults (NOT/kg): 0.2mg daily, incr by 0.2mg daily each wk to max

### 1.6mg 8H oral.

### Macrogol 3350, 105g/L 2-11yr 6.563g in 60ml water, >11yr

### 13.125g in 125ml water: 1 sachet daily oral, incr to 2-3/day if reqd.

### Faecal impactn >2yr: one 13.125g sachet in 125ml water per 5kg

### body wt (adult 8 sachet) consumed in <6hr (max 3 days therapy).

### See also colonic lavage

### Macrogol 400 (polyethylene glycol) 1% + tetrahydrozoline 0. 05%.

### 1 drop/eye 8-12H.

### Mafenide acetate 8.5% cream: apply 2mm layer 12-24H. 5% soltn:

### apply 4-8H to keep dressings wet.

### Maggots of Lucilia sericata, sterile Packs: standard (for standard

### wound), boot (toe, amputation stump), boot (foot), sleeve (limb

### wound). Change maggots after 3 days; sooner if reqd. See

### www.ZooBiotic.co.uk/products-LarvE.htm.

### Magnesium chloride 10% 0.48g/5ml = Mg 1mmol/ml. 0.4ml/kg 12H

### slow IV. Myoc infarct (NOT/kg): 5ml/hr IV for 6hr, then 1ml/hr for

### 24-48hr. VF: 0.1-0.2ml/kg IV.

### Magnesium hydroxide Antacid: 10-40mg/kg (max 2g) 6H oral.

### Laxative: 50-100mg/kg (max 5g) oral. See also aluminium

### hydroxide + magnesium hydroxide + simethicone.

### Magnesium sulphate 50% (2mmol/ml) Deficiency: 0.2ml/kg (max

### 10ml) 12H IM, slow IV. Asthma, digoxin tachycardia, eclampsia,

### prem labour, pul ht: 0.1ml/kg (50mg/kg) IV over 20min, then 0.06

### ml/kg/hr (30 mg/kg/hr); keep serum Mg 1.5-2.5mmol/l (pul ht 3-

### 4mmol/l). Myoc infarct (NOT/kg): 2.5 ml

### Malathion See maldison.

### Maldison 0.5% liquid: 20ml to hair, wash off after 12hr.

### Mannitol 0.25-0.5g/kg IV (2-4ml/kg of 12.5%, 1.25-2.5ml/kg of 20%,

### 1-2ml/kg of 25%) 2H prn, provided serum osmolality <320-

### 330mmol/L.

### Maprotiline 0.15-1mg/kg (adult 10-50mg) 8-24H oral.

### Maraviroc Adult (NOT/kg): 150mg (with strong CYP3A inhibitors,

### incl protease inhibitors), 300mg (with tipranavir or ritonavir), 600mg

### (with CYP3A inducers, incl efavirenz) 12H oral.

### Marimastat Adult (NOT/kg): 5-25mg (usual 10mg) 12H oral.

### Mazindol Adult (NOT/kg): 0.5mg daily oral, up to 3mg daily.

### Measles vaccine (Attenuvax) Live. >12mo: 0.5ml SC once.

### Measles + mumps vaccine (Rimparix) Live. >12mo: 0.5ml SC

### once.

### Measles + mumps + rubella vaccine (MMRII, Priorix) Live. >12mo:

### 0.5ml SC.

### Mebendazole NOT/kg: 100mg 12H x3 days. Enterobiasis

### (NOT/kg): 100mg once, may repeat after 2-4wks.

### Mebeverine 135mg tab: adult (NOT/kg) 1-3 tab daily oral.

### Mebhydrolin 1-2mg/kg (adult 50-100mg) 8-12H oral.

### Mecamylamine 0.05mg/kg (adult 2.5mg) 12H oral; may incr to

### max 0.5mg/kg (adult 25mg) 6H oral.

### Mecasermin 40-80mcg/kg (max 120mcg/kg) 12H SC.

### Mechlorethamine See mustine HCl.

### Meclofenamate 1-2mg/kg (adult 50-100mg) 6-8H oral.

### Meclozine 0.5-1mg/kg (adult 25-50mg) 12-24H oral.

### Mecysteine Adult (NOT/kg): 200mg 8-12H oral.

### Medroxyprogesterone Adult (NOT/kg): 5mg daily for 5-10 days per

### month oral; precocious puberty 5-10mg daily; to achieve

### amenorrhoea 10-20mg daily; uterine hge 60mg daily reducing over

### 10 days to 10mg; malignancy 0.5g daily IM or oral for 4wk, then 1g

### wkly. Depot contraceptiv

### Medroxyprogesterone + oestradiol (2 5mg/1mg, 5/0.625, 5/1,

### 5/2) tabs. Post-menopausal: 1 tab daily oral.

### Medroxyprogesterone 10mg tab + oestradiol 4mg patch NOT/kg:

### 10mg tab daily oral for first 10-14 days of each 28 day cycle, and

### 4mg patch x2/wk continuously.

### Mefenamic acid 10mg/kg (adult 500mg) 8H oral.

### Mefloquine 15mg/kg (adult 750mg) stat, then 10mg/kg (adult

### 500mg) after 6-8hr. Prophylaxis: 5mg/kg (adult 250mg) wkly.

### Mefruside 0.5-1mg/kg (up to 2mg/kg for 3 days) daily 10-14

### days, then 0.5-1mg/kg (adult 25-50mg) every 2-3 days.

### Megestrol acetate NOT/kg: 80mg per dose 12H oral.

### Meglumine antimonate Soltn 85mg/ml of pentavalent antimony.

### Same dose as sodium stibogluconate, deep IM.

### Melatonin Usually 0.1mg/kg (adult 6mg) at night oral.

### Meloxicam 0.15-0.3mg/kg (adult 7.5-15mg) daily oral, PR.

### Melphalan Usually 6mg/m2 daily x5, repeat every 6wk.

### Memantine Adult (NOT/kg): 5mg daily oral, incr by 5mg wkly to

### max 10mg 12H.

### Menadione, menadiol See menaphthone sod bisulphate.

### Menapthone sodium bisulphite (vitamin K3) NOT/kg: 5-10mg x1-

### 2/wk (infant) 10mg daily (child) 10mg 8H (adult) oral. Mitochondrial

### dis (all ages, not/kg): 10mg 6H oral. .

### Meningococcus gp A, C, W135, Y vaccine (Mencevax ACWY,

### Menomune) Inactive. >2yr: ml SC. Boost 1-3yrly.

### Meningococcus gp A, C, W135 and Y conjugated vaccine

### (Menactra) Inactivated. >10yr: 0.5ml IM.

### Meningococcus gp C, conjugate vaccine (Meningitec, Menjugate,

### NeisVac-C) Inactivated. 0.5ml IM: 3 doses 1-2mo apart (6wk-

### 6mo), 2 doses (6-12mo), 1 dose (>12mo).

### Menopausal gonadotrophin See menotrophin.

### Menotrophin (FSH + LH activity) Females (NOT/kg): 75+ 75iu or

### 150+150iu IM daily for 9-12 days until oestrogen levels rise, then

### give HCG. Males (NOT/kg): 75+75iu IM x2-3/wk with HCG 7000iu

### IM x2/wk.

### Mephobarbital See methylphenobarbitone.

### Mepivacaine Max dose 5-7mg/kg.

### Meprobamate 5-10mg/kg (max 800mg) 8-12H oral.

### Meptazinol 4mg/kg (adult 200mg) 3-6H oral.

### Mepyramine 2-4mg/kg (adult 100-200mg) 8H oral.

### Mequitazine 0.1mg/kg (adult 5mg) 12H oral.

### Mercaptamine See cysteamine.

### Mercaptopurine (6MP) 75-100mg/m2 daily oral.

### Meropenem 10-20mg/kg (adult 0.5-1g) 8H IV over 5-30min.

### Severe inftn: 20-40mg/kg (adult 1-2g) 12H (1st wk life) 8H (>1wk)

### or constant infsn.

### Mesalamine See mesalazine.

### Mesalazine Usually high initial dose, lower maintenance. Mesasal,

### Salofalk: 15-20mg/kg (adult 500mg) 8H, decr to 10mg/kg (adult

### 250mg) 8H oral. Adult, NOT/kg: 0.4-1.6g 8H (Asacol, Coltec); 0.5-

### 1g 6H (Pentasa, ethyl-cellulose coat) 6H oral; 2-4 tab daily (Lialda,

### del

### Mesna IV over 30min: 20% of cyclophosphamide or ifosfamide

### dose at 0, 4 and 6 hr. Oral: 40% of dose of cytotoxic at -2, 2 and

### 6hr. Nebulisr: 0.6-1.2g (NOT/kg) 4-6H.

### Mesoridazine Oral: 0.25-3mg/kg (adult 25-150mg) 8H. IM: 0.5mg/kg

### (adult 25mg, max 200mg/day).

### Mesterolone 0.5mg/kg (adult 25mg) 6-12H oral.

### Mestranol 50mcg + norethisterone 1mg Contraception: 1 tab daily

### from 5th to 25th day of menstrual cycle.

### Metaproterenol See orciprenaline.

### Metaraminol IV: 0.01mg/kg stat (repeat prn), then 0.15 mg/kg in

### 50ml 5% dextrose (no heparin) at 1-10ml/hr (0.05-0.5 mcg/kg/min)

### and titrate dose against BP. SC: 0.1mg/kg.

### Metaxalone 15mg/kg (max 800mg) 6-8H oral.

### Metformin Adult (NOT/kg): initially 500mg 8-24H oral, max 1g

### per dose 8H. See also glibenclamide.

### Methacycline NOT/kg: 150mg (>8y) 300mg (>12y) 12H oral.

### Methadone 0.1-0.2mg/kg (adult 5-10mg) 6-12H oral, SC, IM.

### Methamphetamine See methylamphetamine.

### Methazolamide 1-2mg/kg (adult 50-100mg) 8-12H oral.

### Methdilazine 0.1-0.3mg/kg (adult 4-16mg) 12-24H oral.

### Methenamine hippurate or mandelate See hexamine.

### Methenolone Adult (NOT/kg). Oral: 5-10mg 12H. IM: 100mg every

### 1-2wk or 200mg every 2-3wk (carcinoma); 50-100mg every 2wk,

### then every 3-4wk (osteopor).

### Methimazole 0.3-1mg/kg (adult 20-60mg) daily oral, reducing to

### 0.1-0.5mg/kg (adult 5-30mg) daily.

### Methionine 50mg/kg (max 2.5g) oral 4H for 4 doses. Prophylaxis:

### 1mg to paracetamol 5mg.

### Methocarbamol Oral: 30mg/kg (adult 1.5g) 6H for 3 days, then

### 15-20mg/kg (adult 0.75-1g) 6-8H. IV over 5-10 min or IM: 15mg/kg

### (adult 750mg) 6H.

### Methohexital See methohexitone.

### Methohexitone 1-2mg/kg (adult 50-120mg) slow IV.

### Methoin 1mg/kg (adult 50mg) daily oral, may incr by 1mg/kg each

### wk to max 10mg/kg (adult 600mg) daily.

### Methotrexate Leukaemia: typically 3.3mg/m2 IV daily for 4-6wk;

### then 2.5mg/kg IV every 2wk, or 30mg/m2 oral or IM x2/wk; higher

### doses with folinic acid rescue. Intrathecal: 12mg/m2 wkly for 2wk,

### then monthly. Arthritis: 10-20mg/m2 wkly oral, IV, IM or SC. Adult

### psorias

### Methotrimeprazine 0.25-1mg/kg (adult 12.5-50mg) 6-8H oral, IM

### or IV. Up to 1g/day in severe psychosis.

### Methoxamine 0.1-0.4mg/kg (adult 5-20mg) IM, or 0.1-0.2 mg/kg

### (adult 5-10mg) IV over 5-10min (at least 15min between doses).

### Nose drop 0.25%: 1-3drop/nostril 6-12H.

### Methoxsalen Adult (NOT/kg): 20mg 2hr before UV exposure. 1%

### lotion: wkly before 1min of UV light.

### Methscopolamine See hyoscine methobromide.

### Methsuximide 5mg/kg (adult 300mg) daily, may incr to max

### 10mg/kg (adult 400mg) 8-12H oral.

### Methyl aminolevulinate See Aminolevulinic acid.

### Methyclothiazide 0.05-0.2mg/kg (adult 2.5-10mg) daily oral.

### Methylcellulose Constipation: 30-60mg/kg (adult 1.5-3g) with at

### least 10ml/kg (adult 300ml) fluid 12H oral. Obesity: 30mg/kg (adult

### 1.5g) with 5ml/kg water hr before a meal.

### Methylcysteine 4mg/kg (adult 200mg) 6-12H oral.

### Methyldopa 3mg/kg (adult 150mg) 8H oral, may incr to max

### 15mg/kg/dose (adult 750mg).

### Methyldopate 5-20mg/kg (adult 0.25-1g) 6H IV over 1hr.

### Methylene blue 1-2mg/kg (G6PD deficiency 0.4mg/kg) IV prn.

### Septic shock: 2mg/kg stat IV, then 0.25-2mg/kg/hr.

### Methylergometrine Adult (NOT/kg): 200mcg IM, IV over 5min, or

### oral; may repeat in 2hr, then 4-6H.

### Methylphenidate 0.1mg/kg oral 8am, noon and (occasionally) 4pm;

### incr if reqd to max 0.5mg/kg/dose (adult 20mg). Long acting: 20-

### 60mg (18-54mg in US) in morning. Transdermal patch: apply for up

### to 9hr; start with 12.5cm2, and incr to 18.75cm2, 25cm2, and

### 37.5cm2 if rqd. .

### Methylphenobarbitone 4-12mg/kg (adult 200-600mg) daily. .

### Methylprednisolone Asthma: 0.5-1mg/kg 6H oral, IV or IM day 1,

### 12H day 2, then 1mg/kg daily, reducing to minimum effective dose.

### Severe croup: 4mg/kg IV stat, then 1mg/kg 8H. Severe sepsis

### before antibiotics (or within 4hr of 1st dose): 30mg/kg IV once.

### Spinal cord injury (

### Methylprednisolone aceponate 0.1% cream, ointment: apply 12-

### 24H.

### Methyltestosterone NOT/kg: 2.5-12.5mg/day buccal.

### Methysergide maleate 0.02mg/kg (adult 1mg) 12H oral, incr if reqd

### to max 0.04mg/kg (adult 2mg) 8H for 3-6mo.

### Metipranolol 0.1%, 0.3%, adult: 1 drop/eye 12H.

### Metirosine 5-20mg/kg (adult 0.25-1g) 6H oral.

### Metoclopramide 0.15-0.3mg/kg (adult 10-15mg) 6H IV, IM, oral;

### 0.2-0.4mg/kg (adult 10-20mg) 8H PR. Periop: 0.5 mg/kg (adult 15-

### 20mg) IV stat, then 0.2mg/kg (adult 10mg) 4-6H if reqd. With

### chemotherapy: up to 1-2mg/kg 4H IV. .

### Metocurine iodide ICU: 0.4mg/kg IV prn. Theatre: 0.1-0.4 mg/kg

### stat, then 0.01-0.02mg/kg/dose.

### Metolazone 0.1-0.2mg/kg (adult 5-10mg) daily oral. Up to

### 0.5mg/kg (adult 30mg) daily short term.

### Metoprolol IV: 0.1mg/kg (adult 5mg) over 5 min, repeat every 5

### min to max 3 doses, then 1-5mcg/kg/min. Oral: 1-2mg/kg (adult 50-

### 100mg) 6-12H.

### Metronidazole 15mg/kg (max 1g) stat, then 7.5mg/kg (max 1g)

### 12H in neonate (1st maintenance dose 48hr after load if <2kg, 24hr

### in term baby), 8H (4+ wk) IV, PR or oral. Giardiasis: 30mg/kg (adult

### 2g) daily x3 oral. Amoebiasis: 15mg/kg (adult 750-800mg) 8H oral

### for 10 d

### Metyrapone Diagnosis: 15mg/kg (minimum 250mg) 4H x6 dose

### oral. Cushing: 1-20mg/kg (max 1g) 4H.

### Mexiletine IV infsn: 2-5mg/kg (max 250mg) over 15 min, then 5-

### 20mcg/kg/min (max 250mg/hr). Oral: 8mg/kg (max 400mg) stat,

### then 4-8mg/kg (max 400mg) 8H starting 2hr after loading dose.

### Mezlocillin 50mg/kg 6-8H (1st wk life), 4-6H (2+ wk) IM or IV.

### Serious inftn: 60mg/kg (max 3g) 4H.

### Mianserin 0.2-0.5mg/kg (adult 10-40mg) 8H oral.

### Micafungin 3mg/kg (adult 50-150mg) daily IV over 1hr.

### Prophylaxis: 1mg/kg (adult 50mg) daily IV over 1hr.

### Miconazole 7.5-15mg/kg (adult 0.6-1.2g) 8H IV over 1hr. Topical:

### 2% cream, powder, lotion, tincture or gel 12-24H. Vaginal: 2%

### cream or 100mg ovule daily x7.

### Microlax enema <12mo 1.25ml, 1-2yr 2.5ml, >2yr 5ml.

### Midazolam Sedation: usually 0.1-0.2mg/kg (adult 5mg) IV or IM,

### up to 0.5mg/kg used in children; 0.2mg/kg (repeated in 10min if

### reqd) nasal; 0.5 mg/kg (max 20mg) oral. Infusion (ventltd): 3mg/kg

### in 50ml 5%dex-hep at 1-4ml/hr (1-4mcg/kg /min); fitting usually 2-4

### ml/

### Midodrine 0.06mg/kg (adult 3mg) morning and 4-6pm oral, incr

### gradually if required to max 0.2-0.4mg/kg (adult 10-20mg) morning,

### noon, and late afternoon (not after 6pm).

### Mifepristone Termination (NOT/kg): 200-600mg oral once, then if

### abortion incomplete gemeprost 1mg PV or misoprostol 400mcg oral

### or misoprostol 800mcg PV in 48hr.

### Miglitol Adult (NOT/kg): 25mg 8-24H incr over 3-6mo to usual

### maintenance dose of 50mg (max 100mg) 8H oral.

### Milrinone <30kg: 1.5mg/kg in 50ml 5%dex-hep, 2.5ml over 1hr

### (75mcg/kg), then 1-1.5 ml/hr (0.5-0.75mcg/kg/min). >30kg:

### 1.5mg/kg made up to 100ml in 5%dex-hep, 5ml over 1hr

### (75mcg/kg), then 2-3ml/hr (0.5-0.75mcg/kg/min).

### Mineral mixture (Aminogram) <5.5kg: 1.5g/kg daily oral, mixed

### with feed. >5.5kg: 8g daily (NOT/kg).

### Mineral oil See paraffin liquid.

### Minocycline Over 8yr: 4mg/kg (max 200mg) stat, then 2mg/kg

### (max 100mg) 12H oral or IV over 1hr. Sustained release tabs

### (NOT/kg): 45mg (45-59kg), 90mg (60-89kg), 135mg (90kg or more)

### daily oral.

### Minoxidil 0.1mg/kg (max 5mg) daily, incr to max 0.5mg/kg (max

### 25mg) 12-24H oral. Baldness: 2% soltn (male and female) 5% soltn

### (males only) 1ml 12H to dry scalp.

### Mirtazapine 0.3-1mg/kg (adult 15-60mg) daily oral.

### Misoprostol (PGE1 analogue) 5mcg/kg (max 200mcg) 4-6H oral.

### See also mifepristone.

### Mitomycin-C 2mg/m2 IV daily x10 days, repeat only if leucocytes

### >3000/mm3 + platelets >75,000.

### Mitotane 10-80mg/kg (adult 0.5-4g) 6H oral.

### Mitoxantrone See mitozantrone.

### Mitozantrone Breast cancer or lymphoma: 10-14mg/m2 IV over

### 10min every 3wk. Leukaemia: 10-12mg/m2 IV over 10min daily for

### 3-5 days.

### Mivacurium 0.15mg/kg stat, then 0.1mg/kg/dose IV. Infsn: 5-

### 15mcg/kg/min.

### Mizolastine Adult (NOT/kg): slow rel tab, 10mg daily oral.

### Moclobemide 2-3mg/kg (adult 50-150mg) 6-12H oral.

### Modafinil 2-4mg/kg (adult 100-200mg) 12H oral. Adult

### (NOT/kg): 200mg morning (obs sleep apnoea), 1hr before shift

### (night work sleep disorder) oral.

### Moexipril 0.15-0.2mg/kg (adult 7.5-10mg) 8-24H oral.

### Molindone 0.1-1.5mg/kg (adult 50-75mg) 8H oral.

### Molgramostim 5-10mcg/kg daily SC or IV over 6hr.

### Mometasone 0.1% cream or oint: apply daily. 50mcg spray: adult 2

### sprays/nostril daily.

### Montelukast NOT/kg: 4mg (2-5yr) 5mg (6-14yr) 10mg (>14yr) daily

### at bedtime, oral.

### Moracizine 4-6mg/kg (adult 200-300mg) 8H oral.

### Moricizine See moracizine.

### Moroctogog alfa Recombinant human factor 8; see factor 8.

### Morphine Half life 2-4 hr. IM: neonate 0.1mg/kg, child 0.1-0.2

### mg/kg, adult 10-20mg; half this IV over 10 min. IV (ventltd): 0.1-

### 0.2mg/kg/dose (adult 5-10mg). Infsn of 1mg/kg in 50ml 5%dex-hep:

### ventltd neonate 0.5-1.5 ml/hr (10-30mcg/kg/hr), child or adult 1-

### 4ml/h

### Morrhuate sodium Adult (NOT/kg): 50-250mg per injtn.

### Moxifloxacin 10mg/kg (adult 400mg) daily oral. 0.5% ophthalmic: 1

### drop/eye 8H for 7 days.

### Moxisylyte Adult (NOT/kg): 40-80mg 6H oral.

### Moxonidine 4mg/kg (adult 200mg) 8-24H oral.

### Mumps vaccine (Mumpsvax) Live. >12mo: 0.5ml SC once. See

### also measles + mumps + rubella vaccine.

### Mupirocin 2% ointment: apply 8-12H.

### Muromonab-CD3 (Orthoclone OKT3) 0.1mg/kg (adult 5mg) daily

### for 10-14 days IV over 1min.

### Mustine HCl (nitrogen mustard) 0.1mg/kg IV daily for 3-4 days.

### Hodgkins: 6mg/m2 IV.

### Mycophenolate mofetil 600mg/m2 12H oral.

### Nabilone Adult (NOT/kg): 1mg 12H, up to 2mg 8H oral.

### Nabumetone 10-20mg/kg (adult 0.5-1g) 12-24H oral.

### Nadolol 1-5mg/kg (adult 40-240mg) daily oral.

### Nadroparin Venous thrombosis: 90anti-XaU/kg 12H SC.

### Prophylaxis: genrl surgery 2850anti-XaU (adult, NOT/kg) daily SC;

### orthopaedics 40anti-XaU/kg 24H (start 12hr pre-surgery) SC, then

### 55anti-XaU/kg daily. Haemodialysis: 65anti-XaU/kg into arterial line

### at start 4hr s

### Nafarelin Adult (NOT/kg): 200mcg spray to 1 nostril 12H.

### Nafcillin Oral: 15-30mg/kg 6H. Severe inftn (slow IV, IM): 40mg/kg

### (max 2g) 12H (1st wk life), 8H (2nd wk), 6H or constant infsn

### (>2wk).

### Naftifine 1% cream, gel: apply daily.

### Naftidrofuryl 2-4mg/kg (adult 100-200mg) 8H (oral) or 12H (IM, or

### IV or IA infsn over 2hr).

### Nalbuphine 0.2-0.5mg/kg (adult 20-30mg) 3-6H SC, IM or IV.

### Anaesthesia: 0.3-1mg/kg IV over 15min, then 0.2-0.5mg/kg every

### 30min.

### Nalidixic acid 15mg/kg (adult 1g) 6H oral, reducing to 7.5mg/kg

### (adult 500mg) 6H after 2wk.

### Nalmefene Opiate intoxication: 0.007mg/kg IV, and 0.0014 mg/kg

### after 2-5min (15min if IM, SC) if reqd. Postop sedtn: 0.25mcg/kg

### every 2-5min (max 4 doses). Half life 10hr.

### Naloxone Postop sedatn: 0.002mg/kg/dose (0.4mg diluted to

### 20ml, give 0.1ml/kg/dose) repeat every 2min x4 if reqd, then

### 0.3mg/kg in 30ml 5%dex-hep at 1ml/hr (0.01 mg/kg/hr) IV. Opiate

### overdose (including newborn): 0.01 mg/kg (max 0.4mg) (0.4mg

### diluted to 10ml, give

### Naltrexone 0.5mg/kg (adult 25mg) stat, then 1mg/kg (adult 50mg)

### daily oral. Adult (NOT/kg): 380mg every 4wk IM.

### Nandrolone decanoate Anaemia: 1-4mg/kg (adult 50-200mg)

### wkly deep IM. Osteoporsis: adult (NOT/kg) 50mg deep IM every

### 3wk.

### Naphazoline 0.012-0.1%: 1-2drop/nostril, 1drop/eye 3-4H.

### Naproxen 1mg = 1.1mg naproxen sodium. >2yr: 5-10mg/kg

### (adult 250-500mg) 8-12H oral. Adult: 500mg 12H PR.

### Naratriptan 0.05mg/kg (adult 2.5mg), repeat after 4hr if reqd.

### Natalizumab Adult (NOT/kg): 300mg IV over 1hr every 4wk.

### Nateglinide Adult (NOT/kg): 60-120mg 8H oral.

### Nebivolol 0.1mg/kg (adult 5mg) daily oral, incr to max 1mg/kg

### (adult 40mg) daily.

### Nefazodone 1mg/kg (adult 50 mg) 12H oral, incr by 1mg/kg/dose

### (adult 50mg) each wk to 4-6mg/kg (adult 200-300mg) 12H. Slow

### release: daily dose.

### Nefopam hydrochloride Oral: 0.5-2mg/kg (adult 30-90mg) 8H.

### IM: 0.4mg/kg (adult 20mg), may repeat in 6hr.

### Neisseria meningitidis vaccine See meningococcal vacc.

### Nelarabine Child: 650mg/m2 IV over 1hr daily for 5 days;

### repeated every 21 days. Adult: 1500mg/m2 IV over 2hr on days 1,

### 3 and 5; repeated every 21 days.

### Nelfinavir Infant 40-75mg/kg 12H oral, child 50-60mg/kg 12H,

### adult 750mg 8H or 1250-1500mg 12H.

### Neomycin 1g/m2 4-6H oral (max 12g/day). Bladder washout: 40-

### 2000mg/L. See also colistin; dexamethasone; gramicidin.

### Neomycin 0 5% + prednisolone sodium phosphate 0.5%.

### 1drop/eye 4-6H.

### Neostigmine Reverse relaxants: 0.05-0.07mg/kg (adult 0.5-2.5mg)

### IV; suggested dilution: neostigmine (2.5mg/ml) 0.5ml + atropine

### (0.6mg/ml) 0.5ml + saline 0.5ml, give 0.1ml/kg IV. Myasth gravis:

### 0.2-0.5mg/kg (adult 1-2.5mg) 2-4H IM, SC. .

### Nesiritide 2mcg/kg IV, then 0.01mcg/kg/min (range 0.005-

### 0.03mcg/kg/min).

### Netilmicin IV or IM. 1wk-10yr: 8mg/kg day 1, then 6mg/kg daily.

### >10yr: 7mg/kg day 1, then 5mg/kg (max 240-360mg) daily.

### Neonate, 5mg/kg dose: <1200g 48H (0-7 days of life), 36H (8-30

### days), 24H (>30 days); 1200-2500g 36H (0-7 days of life), 24H (>7

### days); term 24H (

### Nevirapine Child: 120mg/m2 daily for 2wk oral, then 150-

### 200mg/m2 daily for 2wk, then 12H if no rash. Adult (NOT/kg):

### 200mg daily for 2wk, than 12H oral if no rash.

### Niacin + lovastatin See lovastatin + niacin.

### Niacin + simvastatin (500mg/20mg, 750/20, 1000/20) Adult

### (NOT/kg): 500mg/20mg at bedtime oral, incr by 500mg every 4wk

### to max 2000/40mg.

### Nicardipine 0.4-0.8mg/kg (adult 20-40mg) 8H oral. 1-3mcg/kg/min

### (max 20mg/hr) IV.

### Niclosamide 50mg/kg (adult 2g) oral.

### Nicotinamide 4% gel: apply sparingly 12-24H.

### Nicorandil 0.1-0.6mg/kg (adult 5-30mg) 12H oral.

### Nicotine inhaler 10mg cartridges. Adult: usually inhale 6-12

### cartridges/day for 3mo, then reduce over 6-8wk.

### Nicotine resin chewing gum NOT/kg: 2-4mg chewed over 30min

### when inclined to smoke; usually need 16-24mg/day, max

### 60mg/day.

### Nicotine transdermal patches Usually 21mg, 14mg, and 7mg per

### 24hr. Adult: if smoked >20cig/day apply strongest patch daily 3-

### 4wk, medium patch daily 3-4wk (initial dose if smoked

### <=20cig/day), then weakest patch daily 3-4wk.

### Nicotinic acid Hypercholesterolaemia and hypertriglyceridaemia:

### 5mg/kg (adult 200mg) 8H, gradually incr to 20-30mg/kg (adult 1-2g)

### 8H oral.

### Nicotinyl alcohol tartrate Adult (NOT/kg): 25-50mg 6H, slow

### release tab 150-300mg 12H oral.

### Nicoumalone 0.2mg/kg (adult 10mg) day 1, 0.12m/kg (adult 6mg)

### day 2, then 0.02-0.25mg/kg (adult 1-12mg) daily oral. INR 2-2.5 for

### prophylaxis, 2-3 for treatment.

### Nifedipine Caps 0.25-0.5mg/kg (adult 10-20mg) 6-8H, tabs 0.5-

### 1mg/kg (adult 20-40mg) 12H oral or sublingual.

### Nilotinib Adult (NOT/kg): 400mg 12H oral.

### Nilutamide Adult (NOT/kg): 300mg daily oral for 4wk, then 150mg

### daily.

### Nimodipine 10-15mcg/kg/hr (adult 1mg/hr) IV for 2hr, then 10-

### 45mcg/kg/hr (adult 2 mg/hr). Adult: 60mg 4H oral.

### Nisoldipine Slow release: 0.2 mg/kg (adult 10mg) daily oral, incr

### to 0.4-0.8mg/kg (adult 20-40mg) daily.

### Nitazoxanide 100mg (12-47mo) 200mg (4-11yr) 500mg (>11yr) 12H

### for 3 days oral.

### Nitrazepam Child epilepsy: 0.125-0.5mg/kg 12H oral. Hypnotic

### (NOT/kg): 2.5-5mg (child) 5-10mg (adult) nocte.

### Nitric oxide 1-40ppm (up to 80ppm used occasionally). 0.1 l/min

### of 1000ppm added to 10 l/min gas gives 10ppm. [NO] = Cylinder

### [NO] x (1 - (Patient FiO2 / Supply FiO2)). [NO] = Cylinder [NO] x

### NO flow / Total flow.

### Nitrofurantoin 1.5mg/kg (adult 50-100mg) 6H oral. Prophylaxis:

### 1-2mg/kg (adult 50-100mg) at night.

### Nitrofurazone 0.2% cream, soltn: apply every 1-3 days.

### Nitrogen mustard See mustine HCl.

### Nitroglycerine See glyceryl trinitrate.

### Nizatidine 3-5mg/kg (adult 150mg) 12H oral for max 8wk, then

### daily. H pylori (adult): 300mg 12-24H.

### Nonacog alfa Recombinant human factor 9, see factor 9.

### Nonoxynol-9 2% (Ortho), 5% (Delfen) cream: 1 applicatorful just

### before intercourse. 12.5% (Delfen) foam: 1 applicatorful <60min

### before intercourse.

### Noradrenaline 0.15mg/kg in 50ml 5%dex-hep at 1-10ml/hr

### (0.05-0.5mcg/kg/min). Flow <2ml/h may cause swings in BP.

### Norelgestromin See ethinyloestradiol + norelgestromin.

### Norepinephrine See noradrenaline.

### Norethisterone Contraception: 350mcg daily, starting 1st day of

### menstruation; or 200mg oily soltn IM in 1st 5 days of cycle,

### repeated once after 8wk. Menorrhagia: 10mg 3H until hge stops,

### then 5mg 6H for 1wk, then 5mg 8H for 2wk; or 5mg 8-12H on days

### 19-26 of cycle. See

### Norethisterone + oestradiol patches Post-menopause (NOT/kg):

### none/4mg (50mcg/24r) patch x2/wk for 2wk, then 30mg/10mg

### (170/50, 250/50mcg in 24hr) patch x2/wk for 2wk; 0.14mg/0.05mg

### patch: 1 patch x2 per wk.

### Norfloxacin 10mg/kg (adult 400mg) 12H oral.

### Norgestimate See ethinyloestradiol + norgestimate.

### Normacol granules 6mo-5yr half teasp 12H, 6-10yr 1 teasp 12H,

### >10yr 1 teasp 8H.

### Nortriptyline 0.5-1.5mg/kg (adult 25-75mg) 8H oral.

### Noxythiolin 1-2.5% soltn into body cavity 12-24H, left at least

### 30min. Max daily dose 200mg/kg (max 10g).

### NTBC (nitro-trifluoromethylbenzoyl cyclohexanedione) 0.5mg/kg

### 12H oral.

### Nystatin 100,000u <12mo, 500,000u (1 tab) >12mo 6H NG or oral.

### Prophylaxis 50,000u <12mo, 250,000u >12mo 8H. Topical:

### 100,000u/g gel, cream or ointment 12H. Vaginal: 100,000u 12-24H.

### See also gramicidin + neomycin + nystatin + triamcinolone cream

### and ointment.

### Octocog alfa (recombinant factor 8) See factor 8.

### Octoxinol (octoxynol) 1% jelly (Ortho-Gynol): 1 teaspoonful on

### diaphragm before intercourse.

### Octreotide Diarrhoea: 1mcg/kg (adult 50mcg) 12-24H SC, may

### incr to 10mcg/kg (adult 250mcg) 8H. IV: 1mcg/kg stat, then 1-

### 5mcg/kg/hr. Chyle: 5mcg/kg/hr IV. Acromegaly (NOT /kg): 0.05-

### 0.1mg 8-12H SC incr if reqd to max 0.5mg 8H for 4wk, then slow

### release 20mg (10-30mg)

### Oestradiol NOT/kg. Post-menopausal (add a progestogen for 14

### days/mo if uterus intact): tab 1-2mg/day oral; patch 0.1% (release

### 25, 37.5, 40, 50, 75, 80, 100mcg/day) to thigh x1-2/wk; metereddose

### pump (0.52mg/dose of 0.06%; 1.53 mg/dose of 1.7%) 1-3

### doses/day to ar

### Oestradiol 2mg (x11 tab), oestradiol 2mg + cyproterone 1mg (x10

### tab) Post-menopausal (NOT/kg): 1 tab daily for 21 days (start 5th

### day of menstruation), then 7 days no tab.

### Oestradiol patch, and oestradiol + levonorgestrel patch Postmenopausal

### (NOT/kg): oestradiol patch (50mcg/24hr) x1/wk for

### 2wk, then oestradiol + levonorgestrel patch (50/10 mcg/24hr) x1/wk

### for 2wk.

### Oestradiol 2mg (x70 tab), oestradiol 2mg + medroxyprogesterone

### 20mg (x14 tab), placebo (x7 tab) Postmenopausal (NOT/kg): 1

### tab daily oral.

### Oestradiol 1mg (x16 tab), oestradiol 1mg + norethisterone 1mg

### (x12 tab) Post-menopausal (NOT/kg): 1 tab daily oral.

### Oestradiol 2mg (x16 tab), oestradiol 2mg + norethisterone 1-2mg

### (x12 tab) Post-menopausal (NOT/kg): 1 tab daily.

### Oestradiol 2mg or 4mg (x12 tab), oestradiol 1mg (x6 tab),

### oestradiol + norethisterone 2mg/1mg or 4mg/1mg (x10 tab)

### Post-menopausal (NOT/kg): 1 tab daily oral.

### Oestradiol patch, and oestradiol + norethisterone patch Postmenopausal

### (NOT/kg): oestradiol patch (50mcg/24hr) x2/wk for

### 2wk, then oestradiol + norethisterone patch (50/170 or 50/250

### mcg/24hr) x2/wk for 2wk.

### 17-beta-Oestradiol 2mg vaginal ring, replace every 3mo.

### Oestriol Inductn puberty: 0.25 mg/day incr to 2mg/day (+

### progestogen 12days/cycle) oral. Epiphyseal maturation: 10mg/day

### (+ progestogen 12days/cycle). Vaginal: 0.5mg daily, reducing to

### x2/wk. Patch (Menorest) 37.5 (3.28mg), 50 (4.33mg), 75 (6.57mg),

### 100 (8.66mg):

### Oestrogen See ethinyloestradiol.

### Oestrone Adult (NOT/kg). Menopause: oral 0.625-5mg daily;

### vaginal 0.1-1mg daily, decr to 1mg x2-3/wk. Hypogonadism: 1.25-

### 7.5mg daily oral.

### Oestropipate Adult (NOT/kg): 0.625-7.5mg daily starting 1st day

### menstruation, for 3 of every 4wk oral. Menopause: 1.5-3mg daily

### oral. Intravaginal: 2-4g cream daily.

### Ofloxacin 5mg/kg (adult 200mg) 8-12H, or 10mg/kg (adult

### 400mg) 12H oral or IV over 1hr. 0.3%: 1drop/eye hrly for 2 days

### (4H overnight), reducing to 3-6H.

### OKT3 See muromonab-CD3.

### Olanzapine 0.1-0.2mg/kg (adult 5-10mg) daily oral; slow incr to

### 0.4mg/kg (adult 20mg) daily if reqd. See also fluoxetine.

### Olmesartan 0.4-0.8mg/kg (adult 20-40mg) daily oral. See also

### amlodipine + olmesartan.

### Olopatadine 0.1% soltn: 1 drop/eye twice a day.

### Olpadronate 0.5mg/kg daily oral.

### Olsalazine NOT/kg: 250mg 12H, incr to max 500mg 6H oral.

### Maintenance: 500mg 12H.

### Omalizumab NOT/kg: 150-375mg SC every 2-4wk depending on

### body weight and serum IgE level.

### Omeprazole Usually 0.4-0.8mg/kg (adult 20-40mg) 12-24H oral.

### ZE synd: 1mg/kg (adult 60mg) 12-24H oral, incr up to 3mg/kg (adult

### 120mg) 8H if reqd. IV: 2mg/kg (adult 80mg) stat, then 1mg/kg (adult

### 40mg) 8-12H. H.pylori: 0.8mg/kg (adult 40mg) daily oral with

### metronida

### Ondansetron IV: prophylaxis 0.15mg/kg (adult 4mg); treatment

### 0.2mg/kg (adult 8mg) over 5 min, or 0.2-0.5mcg /kg/min. Oral: 0.1-

### 0.2mg/kg (usual max 8mg) 6-12H.

### Oprelvekin (IL-11) 2mg/m2 (adult 50mcg/kg) SC daily.

### Oral rehydratn soltn (ORS) See glucose electrolyte soltn.

### Orciprenaline Oral: 0.25-0.5mg/kg (adult 20mg) 6H. Resp soltn

### (2%): 0.5ml diltd to 4ml 3-6H (mild), 1ml diltd to 4ml (moderate),

### undiluted continuously (severe, in ICU). Aerosol 750mcg/dose: 2

### puffs 4-6H.

### Orlistat 1.5-3mg/kg (adult 60-120mg) with each main meal

### containing fat (max 3 doses/day).

### Ornipressin (POR 8) IV: 0.1u/kg/hr (max 6u/hr) for max 4hr, then

### 0.03u/kg/hr (max 1.5u/hr). SC: 5u in 30ml saline, max total dose

### 0.1u/kg.

### Orphenadrine 1-2mg/kg (adult 50-100mg) 8H oral. .

### Osalazine Adult (NOT/kg): 500mg 6H oral.

### Oseltamivir 2mg/kg (adult 75mg) 12H for 5 days oral. Prophylaxis:

### 2mg/kg (adult 75mg) daily.

### Oxacillin 15-30mg/kg 6H oral, IV, IM. Severe inftn: 40 mg/kg (max

### 2g) 12H (1st wk life), 8H (2nd wk), 6H or infsn (>2wk).

### Oxaliplatin 85mg/m2 every 2wk over 2-6hr IV before 5-FU.

### Oxandrolone 0.1-0.2mg/kg (adult 2.5-20mg) daily oral. Turner's

### synd: 0.05-0.1mg/kg daily.

### Oxaprozin Usually 20mg/kg (max 1200mg), range 10-26mg/kg

### (max 1800mg), daily oral.

### Oxazepam 0.2-0.5mg/kg (adult 10-30mg) 6-8H oral.

### Oxcarbazepine 4-5mg/kg (adult 300mg) 12H oral; incr wkly by

### max 5mg/kg/dose (adult 300mg) to usually 15mg/kg/dose (adult

### 750mg), max 25mg/kg/dose (adult 1200mg).

### Oxerutin 10mg/kg (adult 500mg) 12H oral.

### Oxethazaine 10mg/5ml (with Al hydrox + Mg hydrox): adult

### (NOT/kg) 5-10ml 6-8H oral. .

### Oxiconazole 1% cream, lotion: apply 12-24H.

### Oxitropium Inhaltn: 200mcg (NOT/kg) 8-12H.

### Oxpentifylline Adult (NOT/kg): slow release tab 400mg 8-12H

### oral.

### Oxprenolol 0.5-2mg/kg (adult 30-120mg) 8-12H oral.

### Oxtriphylline See choline theophyllinate.

### Oxybuprocaine 4mg/ml (0.4%): 1 drop/eye 8-12H. Deep anaes: 1

### drop/eye every 90sec x3 doses. See also fluorescein +

### oxybuprocaine.

### Oxybutynin <5yr: 0.2mg/kg 8-12H oral. >5yr (NOT/ kg): 2.5-5mg

### 8-12H oral. Slow rel: adult 5-30mg daily oral. Adult (NOT/kg): apply

### 39cm2 patch (3.9mg/day) x2/wk.

### Oxycodone 0.1-0.2mg/kg (adult 5-10mg) 4-6H oral, SC or IV

### (beware hypoventilation); incr if reqd. IV infsn: 0.05mg/kg/hr (adult

### 2mg/hr) adjusted. Slow release: 0.6-0.9mg/kg (adult 10mg) 12H

### oral, incr if reqd. Suppos: adult 30mg 6-8H PR.

### Oxymetazoline 0.25mg/ml = 0.025% (<6yr), 0.5mg/ml = 0.05%

### (>6yr): 2-3 drops or sprays in each nostril 8-12H.

### Oxymetholone 1-2mg/kg (up to 5mg/kg) daily oral.

### Oxymorphone Usually 0.02-0.03mg/kg (adult 1-1.5mg) 4-6H IM

### or SC. Slow IV: 0.01mg/kg (adult 0.5mg) 4-6H. Oral: 0.1-0.4mg/kg

### (adult 5-20mg) 4-6H; slow-release adult 5mg 12H. PR: 0.1mg/kg

### (adult 5mg) 4-6H.

### Oxytetracycline >8yr (NOT/kg): 250-500mg 6H oral, or 250-

### 500mg 6-12H slow IV.

### Oxytocin Labour (NOT/kg): 1-4mU/min IV, may incr to 20 mU/min

### max. Lactation: 1 spray (4iu) into each nostril 5min before infant

### feeds.

### Packed cells 4ml/kg raises Hb 1g%. 1 bag is about 300ml.

### Paclitaxel 175mg/m2 IV every 3wk, x3-6 doses. Albumin-bound:

### 260mg/m2 IV every 3wk.

### Palifermin 60mcg/kg IV daily for 3 days before chemo, and for 3

### days after.

### Palivizumab 15mg/kg IM once a month.

### Paliperidone (3mg, 6mg, 9mg slow release) Adult (NOT/ kg):

### usually 6mg daily oral; may incr by 3mg every 5-7 days.

### Palonosetron Adult: 0.25mg IV 30min before chemo.

### Pamidronate Osteoporosis, OI: 3-7mg/kg daily oral, 1mg/kg (adult

### 15-90mg) IV over 4hr daily x3 every 4mo, or once every 3-4wk.

### Hypercalcaemia 20-50mg/m2 (depending on Ca level) IV over 4hr

### every 4wk.

### Pancreatic enzymes Cotazyme, Creon, Nutrizym, Pancrease,

### Pancrex, Ultrase, Viokase. NOT/kg: usually 1-5 caps with meals.

### Max lipase 10,000u/kg/day.

### Pancuronium ICU: 0.1-0.15mg/kg IV prn. Theatre: 0.1mg /kg IV,

### then 0.02mg/kg prn. Infsn: 0.25-0.75mcg/kg/min.

### Panitumumab 6mg/kg IV over 1-2hr every 14 days.

### Pantoprazole 1.0mg/kg (adult 40mg) 12-24H oral, IV. GI hge, adult:

### 80mg stat, then 8mg/hr. ZE: 80mg 8-12H adjusted to achieve acid

### <10mmol/l.

### Papaveretum (Omnopon) 0.2mg/kg IV, 0.4mg/kg IM (half life 2-

### 4hr). ICU: 0.3mg/kg IV, 0.6mg/kg IM. See also hyoscine +

### papaveretum.

### Papaverine Adult (NOT/kg): 150-300mg 12H oral, 12-40 mg x1-

### 2/wk intracavernosal. IA lines: 0.12mg/ml.

### Para-aminobenzoic acid See aminobenzoate.

### Para-aminohippuric acid See aminohippuric acid.

### Paracetamol Oral or IV: 20mg/kg stat, then 15mg/kg 4H (max

### 4g/day); child usual daily max 90mg/kg for 48hr, then max

### 60mg/kg. Rectal: 40mg/kg stat, then 30mg/kg 6H (max 5g/day).

### Overdose: acetylcysteine. .

### Paraffin Liquid: 1ml/kg (adult 30-45ml) daily oral. Liquid 50% +

### white soft 50%, ointmnt: apply 6-12H. See also agar.

### Paraldehyde IM: 0.2ml/kg (adult 10ml) stat, then 0.1 ml/kg 4-6H. IV:

### 0.2ml/kg (adult 10ml) over 15 min, then 0.02ml/kg/hr (max

### 1.5ml/hr). Rectal, NG: 0.3ml/kg (adult 10ml) dilute1:10.

### Parathyroid hormone Adult (NOT/kg): 100mcg daily SC. See also

### teriparatide.

### Parecoxib Adult (NOT/kg): 40mg stat IM or IV, then 20-40mg 6-

### 12H; max 80mg/day.

### Paricalcitol 0.04-0.1mcg/kg x2-3/wk IV during dialysis, incr every

### 2-4wk if reqd to max 0.24mcg/kg. Or dose in mcg = [iPTH

### picomol/L] / 7.

### Paroxetine 0.4mg/kg (adult 10mg) daily oral, incr if rqd over 4wk

### to 1mg/kg (adult 20-60mg) daily.

### Pegademase 10u/kg IM wkly, incr to 20u/kg wkly.

### Pegaptanib sodium Adult: 1.65mg (0.3mg of free acid form) by

### intravitreous inj every 6wk.

### Pegaspargase 82.5iu/kg (<0.6m2) or 2500iu/m2 (>0.6m2) IM, or

### IV over 2hr, every 14 days.

### Pegfilgrastim >44kg: 6mg SC 24hr after chemo.

### Peginterferon alfa-2a Hep C, adult (NOT/kg): 180mcg wkly SC,

### plus ribavirin 1g (1.2g if >75kg) daily oral, for 48wk.

### Peginterferon alfa-2b Hep C: 1.5mcg/kg wkly, plus ribavirin

### 15mg/kg (adult 800mg) daily oral, for 48wk.

### Pegvisomant 40mg SC stat, then 10mg daily adjusted up or down

### by 5mg (max 30mg/day) every 4-6wk based on serum IGF-1

### concentration.

### Pemoline >6yr (NOT/kg): 20-120mg daily oral.

### Penbutolol 0.4-1.5mg/kg (adult 20-80mg) daily oral.

### Penciclovir 1% cream (10mg/g): apply x6/day for 4 days.

### Penicillamine (d-penicillamine) Arthritis: 1.5mg/kg (adult 125mg)

### 12H oral, incr over 3mo to max 3mg/kg (adult 375 mg) 6-8H.

### Wilson's dis, lead poisoning: 5-7.5 mg/kg (adult 250-500mg) 6H

### oral. Cystinuria: 7.5mg/kg (adult 250-1000 mg) 6H oral, titrated to

### urine cystine <100-200mg/day.

### Penicillin, benzathine 1mg = 1250u. Usually 25mg/kg (max 900mg)

### IM once. Venereal disease: 40mg/kg (max 1.8g) IM once. Strep

### proph: 25mg/kg (max 900mg) IM 3-4wkly, or 10mg/kg IM 2wkly.

### Penicillin, benzathine + procaine 900mg/300mg in 2ml: 0-2yr

### half vial, 3yr or more 1 vial IM once.

### Penicillin, benzyl (penicillin G, crystalline) 1mg = 1667u.

### 30mg/kg 6H. Severe inftn: 50mg/kg (max 2g) IV 12H (1st wk life),

### 6H (2-4 wk), 4H or constnt infsn (>4 wk). .

### Penicillin, procaine 1mg = 1000u. 25-50mg/kg (max 1.2-2.4g )

### 12-24H IM. Single dose: 100mg/kg (max 4.8g).

### Penicilloyl polylysine (Prepen) 0.00006 molar. Scratch: 1 drop.

### Intradermal: 0.01-0.02ml (NOT/kg).

### Pentaerythritol tetranitrate 0.2-1mg/kg (adult 10-60mg) 6-8H oral.

### Pentagastrin 6mcg/kg SC, or 0.6mcg/kg/hr IV.

### Pentamidine isethionate 3-4mg/kg (1.7-2.3mg/kg base) IV over

### 2hr or IM daily for 10-14 days (1mg base = 1.5mg mesylate =

### 1.74mg isethionate). Neb: 600mg/6ml daily for 3wk (treatment),

### 300mg/3ml every 4wk (prophylaxis).

### Pentastarch 10% soltn: 10-40mg/kg IV.

### Pentazocine Oral: 0.5-2.0mg/kg (adult 25-100mg) 3-4H. SC, IM or

### slow IV: 0.5-1mg/kg (adult 30-60mg) 3-4H. PR: 1mg/kg (adult

### 50mg) 6-12H.

### Pentobarbital See pentobarbitone.

### Pentobarbitone 0.5-1mg/kg (adult 30-60mg) 6-8H oral, IM, slow

### IV. Hypnotic: 2-4mg/kg (adult 100-200mg).

### Pentosan 2mg/kg (adult 100mg) 8H oral.

### Pentostatin 4mg/m2 IV wkly.

### Pentoxyverine 0.3mg/kg (adult 15mg) 3-6H oral.

### Peppermint oil Adult (NOT/kg). 0.2ml cap: 1-2 8H oral.

### Pergolide Parkinson's: 1mcg/kg (max 50mcg) daily, incr to max

### 25mcg/kg (max 2mg) 8H oral. Hyperprolactinaemia: 0.5-3mcg/kg

### daily.

### Perhexiline 2mg/kg (adult 100mg) daily oral; adjust every 2-4wk

### to max 6-8mg/kg (adult 300-400mg) daily. Maintain plasma level

### 150-600mcg/l.

### Pericyazine 0.5mg/yr of age (1-10yr) 10mg (>10yr) daily oral, incr

### if reqd to max 1mg/yr (1-10yr) 25mg (>10yr) 8H.

### Perindopril 0.05-0.15mg/kg (adult 2-8mg) daily oral.

### Permethrin 1% creme rinse (head lice): wash hair, apply creme

### for 10min, wash off; may repeat in 2wk. 5% cream (scabies): wash

### body, apply to whole body except face, wash off after 12-24hr.

### Perphenazine 0.1-0.3mg/kg (adult 5-20mg) 8-12H oral.

### Pertussis See diphtheria + tetanus + pertussis vaccine.

### Pethidine 0.5-1mg/kg (adult 25-50mg) IV, 0.5-2mg/kg (adult 25-

### 100mg) IM (half life 2-4hr). Infsn: 5mg/kg in 50ml at 1-4ml/hr (0.1-

### 0.4mg/kg/hr). PCA 5mg/kg in 50ml: usually bolus 2ml with lockout

### 5min, optional background 0.5ml/hr. .

### Phenacemide 10-20mg/kg (adult 0.5-1g) 8H oral.

### Phenazone See benzocaine + phenazone.

### Phenazocine 0.1-0.4mg/kg (adult 5-20mg) 4-6H oral or sublingual.

### Phenazopyridine 4mg/kg (adult 200mg) 6H oral for 2 days.

### Phendimetrazine 0.4-1.4mg/kg (adult 20-70mg) 8H oral.

### Phenelzine 0.3-2mg/kg (adult 15-90mg) 8H oral.

### Phenindamine 0.5-1mg/kg (adult 25-50mg) 8-12H oral.

### Phenindione 2mg/kg (adult 100mg) 12H day 1, 1mg/kg (adult

### 50mg) 12H day 2, then 0.25-1mg/kg (adult 12.5-50mg) 12H oral.

### INR for prophylaxis 2-2.5, treatment 2-3.

### Pheniramine 0.5-1mg/kg (adult 25-50mg) 6-8H oral. Slow release

### tab 75mg at night.

### Phenobarbital See phenobarbitone.

### Phenobarbitone Loading dose in emergency: 20-30mg/kg IM or IV

### over 30min stat. Ventilated: repeat doses of 10-15mg/kg up to

### 100mg/kg per day (beware hypotension). Usual maintenance:

### 5mg/kg (adult 300mg) daily IV, IM or oral. Infant colic: 1mg/kg 4-8H

### oral. Level 80-120

### Phenolphthalein 0.5-5mg/kg (adult 30-270mg) at night oral. See

### also agar + paraffin + phenolphthalein.

### Phenoperidine 0.03-0.05mg/kg (adult 1mg) every 40-60min.

### Ventilated: 0.1-0.15mg/kg (adult 2-5mg) every 40-60min.

### Phenothrin Apply; shampoo after 30min (0.5% mousse) 2hr

### (0.2% lotion), 12hr (0.5% emulsion); comb hair when wet. .

### Phenoxybenzamine 0.2-0.5mg/kg (adult 10-40mg) 8-12H oral.

### Cardiac surgery: 1mg/kg IV over 1-4hr stat, then 0.5 mg/kg 8-12H

### IV over 1hr or oral.

### Phenoxymethylpenicillin (penicillin V) 7.5-15mg/kg (adult 250-

### 500mg) 6H oral. Proph: 12.5mg/kg (adult 250mg) 12H.

### Phentermine Adult (NOT/kg): 30-40mg daily oral, reducing to 15-

### 40mg daily.

### Phentermine resin Adult (NOT/kg): 15-30mg daily oral.

### Phentolamine 15mg/kg in 50ml 5%dex-hep at 1-10ml/hr (5-

### 50mcg/kg/min) IV. May accumulate (half-life 19min, longer if renal

### impairment).

### Phenylbutazone Initially 2mg/kg (adult 100mg) 4H, reducing to 1-

### 2mg/kg (adult 50-100mg) 6-8H oral.

### Phenylephrine IV: 2-10mcg/kg stat (adult 500mcg), then 1-

### 5mcg/kg/min. SC or IM: 0.1-0.2mg/kg (max 10mg). Oral: 0.2mg/kg

### (max 10mg) 6-8H. 0.15%, 10% eye drops: 1 drop/eye 6-8H. 0.25%,

### 0.5% nose drops: 1-3 drops/sprays per nostril 6-8H. See also

### chlorpheniramine.

### Phenylephrine 0 12% + prednisolone acetate 1%. 1 drop per eye

### 6-12H.

### Phenyltoloxamine 1mg/kg (adult 50mg) 8H oral.

### Phenytoin Loading dose in emergency: 15-20mg/kg (max 1.5g)

### IV over 1 hr. Initial maintenance, oral or IV: 2mg /kg 12H (preterm);

### 3mg/kg 12H (1st wk life), 8H (2wk-4yr), 12H (5-12yr); 2mg/kg

### (usual max 100mg) 8H >12 yr. Level 40-80 umol/L (x0.25 =

### mcg/ml). .

### Pholcodine 0.1-0.2mg/kg (adult 5-15mg) 6-12H oral.

### Phosphate, potassium (1mmol/ml) 0.1-1.5mmol/kg/day (max

### 70mmol/day) IV infsn.

### Phosphate, sodium Laxative, diluted, NOT/kg: 250mg (2-4yr)

### 250-500mg (>4yr) 6H oral.

### Phosphate, sodium (Fleet enema) Na 1.61mEq/l \+ PO4 4.15

### mEq/l + P 1.38mEq/l: 33ml (2-5yr), 66ml (5-11yr), 133ml (adult)

### rectal.

### Phosphatidylcholine Usually 60mg/kg (max 3g) daily oral.

### Phosphocysteamine 10mg/kg 6H oral, incr by 2.5 mg/kg/dose

### every 2wk to 10-20mg/kg 6H so leukocyte half-cysteine <2nmol /

### mg protein 6hr after dose.

### Physostigmine 0.02mg/kg (max 1mg) IV every 5 min until

### response (max 0.1mg/kg), then 0.5-2.0mcg/kg/min.

### Phytomenadione (vitamin K1) Deficiency with hge: FFP 10ml/kg,

### then 0.3mg/kg (max 10mg), IM or IV over 1hr. Prophylaxis in

### neonates (NOT/kg): 1mg (0.1ml) IM at birth. Warfarin reversal:

### 0.1mg/kg (max 5mg) SC or oral (repeat if reqd); if severe hge

### 0.3mg/kg (max 10mg) with FFP 10ml/kg

### Phytonadione See phytomenadione.

### Picibanil (OK-432) 1 Klinishe Einheit = 0.1mg. 1mg into tumour

### 1-2wk preop, then 0.5mg/2wk ID for 1yr postop.

### Pilocarpine 0.1mg/kg (adult 5mg) 4-8H oral. 0.5%, 1%, 2%, 3%,

### 4% eye drops: 1 drop/eye 6-12H. .

### Pimecrolimus 1% cream: apply 12H.

### Pimozide 0.04mg/kg (adult 20mg) daily oral, incr if reqd to max

### 0.4mg/kg (adult 20mg) daily.

### Pindolol 0.3mg/kg (adult 15mg) 8-24H oral.

### Pine tar Gel, solution: 5ml to baby bath, 15-30ml to adult bath;

### soak for 10min.

### Pioglitazone Adult (NOT/kg): 15-45mg daily oral. See also

### glimepiride + pioglitazone.

### Pipecuronium 20-85mcg/kg IV stat, then 5-25mcg/kg prn.

### Piperacillin 50mg/kg (adult 2-3g) 6-8H IV. Severe inftn: 75mg/kg

### (adult 4g) 8H (1st wk life) 6H (2-4wk) 4-6H (>4wk) or constant infsn.

### Piperacillin 1g + tazobactam 125mg As for piperacillin.

### Piperazine 75mg/kg (max 4g) oral daily for 2 days (ascaris), 7

### days (pinworm).

### Piperazine oestrone sulphate Induction puberty (NOT/kg):

### 0.156mg daily, incr over 2-3yr to 1.25mg (add progestogen for 12

### days per cycle).

### Piperonyl butoxide bioallethrin Apply enough to wet scalp or body,

### leave 30min, wash off.

### Pipotiazine Oily injtn: initially 0.5mg/kg (adult 25mg), then gradual

### incr to 1-4mg/kg (adult 50-200mg) every 4wk IM.

### Piracetam 15mg/kg (max 800mg) 8H oral, IM or IV.

### Pirbuterol Oral: 0.2-0.3mg/kg (adult 10-15mg) 6-8H. Inhaltn

### (NOT/kg): 0.2-0.4mg 4-6H.

### Piroxicam 0.2-0.4mg/kg (adult 10-20mg) daily oral. Gel 5mg/g:

### apply 1g (3cm) 6-8H for up to 2wk.

### Pivampicillin 15mg/kg (adult 500mg) 8-12H oral.

### Pivampicillin 1 25mg + pivmecillinam 1mg. 10mg/kg per dose

### (adult 250mg) of pivampicillin 12H oral.

### Pivmecillinam 5-10mg/kg (adult 200-400mg) 6-8H oral.

### Pizotifen NOT/kg: 0.5mg daily oral, incr if reqd to max 0.5mg

### morning and 1mg at night.

### Plague vaccine (CSL) Inactivated. Adult (>11yr): 0.5ml SC stat, and

### 1-4wk later (2 doses); boost every 6mo. Child: 0.1ml (6mo-2yr),

### 0.2ml (3-6yr), 0.3ml (7-11yr) SC stat, 1-4wk later, and 1-4wk later

### (3 doses); boost every 6mo.

### Platelets 10ml/kg IV stat, then as reqd. 1 unit approx 60ml.

### Plicamycin Testicular tumours: 25-30mcg/kg daily for 8-10 days

### IV over 6hr, repeat monthly if response. Hypercalcaemia: 25mcg/kg

### daily for 3-4 days, then x1-3/wk.

### Pneumococcal vaccine, polysaccharide (Pneumovax 23)

### Inactivtd. >2yr: 0.5ml SC or IM once. Boost every 5yr.

### Pneumococcal vaccine, CRM conjugate (Prevenar) Inactivated.

### 0.5ml IM. <6mo: 2mo, 3mo, 4mo, 12-15mo (4 doses). 6-11mo:

### 6mo, 7mo, 12-15mo (3 doses). 12-23mo: 2 doses 2mo apart.

### >23mo: 1 dose. .

### Podophyllotoxin 0.5% paint: apply 12H for 3 days, then none for 4

### days; 4wk course.

### Podophyllum 15%-25% soltn, oint: apply to wart x2/day.

### Poliomyelitis vaccine, oral (Sabin) Live. 2 drops oral at 2mo, 4mo

### and 6mo (3 doses). Boost at 5yr, and if going to epidemic area.

### Poliomyelitis vaccine, SC (IPOL) Inactivated. 0.5ml SC stat, 8wk

### later, and 8wk later (3 doses). Boost 12mo later, and at school

### entry.

### Poloxalkol See poloxamer.

### Poloxamer 10% soltn: <6mo 10drops, 6-18mo 15drops, 18mo-3yr

### 25drops 8H oral.

### Polyethylene glycol See colonic lavage, macrogol.

### Polymyxin B See bacitracin; dexamethasone.

### Polynoxylin 10% gel: apply 12H.

### Polygeline 10-20ml/kg (may be repeated). Half life 2hr.

### Polystyrene sulphonate See sodium polystyrene sulph.

### Polythiazide 0.02-0.1mg/kg (adult 1-4mg) daily oral.

### Polyvinyl alcohol 1.4%, 3% soltn: 1 drop/eye prn.

### Poractant alfa (porcine surfactant, Curosurf) Intratracheal:

### 200mg/kg stat, then up to 4 doses of 100mg/kg 12H if reqd.

### Porfimer 2mg/kg IV, then 630nm laser light after 40-50hr and 96-

### 120hr; max 3 courses at least 30 days apart.

### Posaconazole Invasive inftn: 4mg/kg (adult 200mg) 6H oral.

### Oral candida: 4mg/kg (adult 200mg) stat, then 2mg/kg (adult

### 100mg) daily. Prophylaxis: 4mg/kg (adult 200mg) daily. .

### Potassium Deficiency: usually 0.3mmol/kg/hr (max 0.4

### mmol/kg/hr) for 4-6 hr IV, then 4mmol/kg/day. Max oral dose

### 1mmol/kg (<5yr), 0.5mmol/kg (>5yr). Maintenance 2-4mmol/kg/day.

### If peripheral IV, max 0.05 mmol/ml. 1g KCl = 13.3mmol K, 7.5% KCl

### = 1mmol/ml.

### Potassium citrate See citric acid + potassium citrate.

### Potassium guaiacolsulfonate 1-3mg/kg (adult 50-160 mg) 4-6H

### oral.

### Potatoes, roast Oven 230°C (210°C fan-forced), pan with 5mm

### peanut oil in oven; peel potatoes, boil 30min until friable on outside,

### drain, put in hot oil, cook on top shelf of oven for 60-100min until

### crisp (baste every 20min).

### Povidone-iodine Cream, oint, paint, soltn: apply 6-12H.

### Pralidoxime 50mg/kg (adult 2g) over 30min, then 20 mg/kg/hr

### (adult 1g/hr) for 48hr, then 20mg/kg (adult 1g) 4H.

### Pramipexole Adult (NOT/kg): 0.125mg 8H incr by 0.125-0.25mg

### every 5-7 days to 0.5-1.5mg 8H oral. Restless legs: 0.125mg (max

### 0.5mg) 2-3 hours before bedtime.

### Pramlintide Reduce insulin dose by 50% initially. Adult, NOT/kg.

### Type 1 diabetes: 15mcg SC before meals (x4/day), incr if tolerated

### to 30-60mcg/dose. Type 2: 60mcg SC before meals (x4/day), incr if

### tolerated to 90-120mcg/dose.

### Pramocaine See hydrocortisone + pramocaine cream.

### Pramoxine 1% cream, lotion: apply 6-8H.

### Pravastatin Adult (NOT/kg): 20-80mg at bedtime oral.

### Praziquantel 20mg/kg oral once (tapeworm), 4H x3 doses

### (schistosomiasis), 8H x6 doses (other flukes), 8H 14 days

### (cysticercosis).

### Prazosin 5mcg/kg (max 0.25mg) test dose, then 0.025-0.1 mg/kg

### (adult 1-5mg) 6-12H oral. .

### Prednisolone Oral. Alopecia, autoimm liver, Crohn's, epilepsy, SLE,

### ulcerative col: 2mg/kg daily, gradually reducing. Asthma: 0.5-

### 1mg/kg 6H for 24hr, 12H x2, then 1mg/kg daily. Croup: 1mg/kg stat

### and in 12hr; severe 4 mg/kg stat, then 1mg/kg 8H. ITP: 4mg/kg

### daily. Nep

### Prednisolone sodium phosphate 0.5%: ear 2-3 drops/ear, eye 1

### drop/eye 2-6H.

### Prednisone Action equivalent to prednisolone.

### Pregabalin Adult (NOT/kg): 50mg 8H oral, incr gradually if reqd to

### max 200mg 8H.

### Prilocaine Max dose 6mg/kg (0.6ml/kg of 1%). With adrenaline

### max dose 9mg/kg (0.9ml/kg of 1%).

### Primaquine Usually 0.3mg/kg (adult 15mg) daily for 14-21 days

### oral. Gameteocyte: 0.7mg/kg (adult 45mg) once.

### Primidone Initially 2.5mg/kg (adult 125mg) at night, incr if reqd to

### max 15mg/kg (adult 750mg) 12H oral. Trough level

### (phenobarbitone) 60-120umol/L.

### Probenicid 25mg/kg (adult 1g) stat, then 10mg/kg (adult 500mg)

### 6H oral.

### Probucol 10mg/kg (adult 500mg) 12H oral.

### Procainamide IV: 0.4mg/kg/min (adult 20mg/min) for max

### 25min, then 20-80mcg/kg/min (max 2g/day). Oral: 5-8mg/kg 4H.

### Level 3-10mcg/ml.

### Procaine Max dose 20mg/kg (1ml/kg of 2%).

### Procarbazine 1mg/kg (adult 50mg) daily oral, incr over 4-6 days to

### 4-6mg/kg (adult 200-300mg) daily until remission, then 1-2mg/kg

### (adult 50-100mg) daily. Suspend if leucocytes <3000/mm3 or

### platelets <80,000/mm3.

### Prochlorperazine 1mg base = approx 1.5mg edisylate, maleate or

### mesylate. Only use if >10kg. Oral (salt): 0.2mg/kg (adult 5-10mg) 6-

### 8H, slow incr if reqd to max 0.6mg/kg (max 35mg) 6H in psychosis.

### IM, slow IV (salt): 0.2mg/kg (adult 12.5mg) 8-12H. Buccal (salt):

### 0.05-0.1m

### Procyclidine 0.05-0.2mg/kg (adult 2.5-10mg) 6-8H oral.

### Progesterone Adult (NOT/kg). Post-menopausal: 100mg daily

### on days 1-25 of cycle, or 200mg daily on days 15-26. Premenst

### syn: 200-400mg PV or PR 12-24H (last half of cycle). Dysf ut hge:

### 5-10mg/day IM for 5-10 days before menses. Prevent abrtn: 25-

### 100mg IM every 2-4 da

### Proguanil 3.5mg/kg (adult 200mg) daily oral after food. See also

### atovaquone + proguanil.

### Promazine Oral: 2-4mg/kg (adult 100-200mg) 6H. IM 0.7mg/kg

### (max 50mg) 6-8H.

### Promethazine Antihist, antiemetic: 0.2-0.5mg/kg (adult 10-

### 25mg) 6-8H IV, IM or oral. Sedative, hypnotic: 0.5-1.5mg/kg (adult

### 25-100mg).

### Proxymetacaine 0.5%: 1 drop/eye before procedure.

### Propacetamol IV preparation: 1g = 0 5g paracetamol.

### Propafenone Oral: 70mg/m2 (adult 150mg) 8H, incr if reqd to max

### 165mg/m2 (adult 300mg) 8H. IV: 2mg/kg over 2hr, then

### 4mcg/kg/min incr if reqd to max 8mcg/kg/min.

### Propamidine 0.1%: 1 drop/eye 6H for up to 2 days.

### Propantheline 0.3-0.6mg/kg (adult 15-30mg) 6H oral.

### Propiverine 0.3mg/kg (adult 15mg) 6-12H oral.

### Propofol Sedation in ICU: 1-3mg/kg/hr (max 4mg/kg/hr) IV, for no

### longer than 48 hr. Short-term anaesthesia: child 2.5-3.5mg/kg stat,

### then 7.5-15mg/kg/hr IV; adult 1-2.5mg/kg stat, then 3-12 mg/kg/hr

### IV.

### Propranolol 0.2-0.5mg/kg (adult 10-25mg) 6-12H oral, slow incr to

### max 1.5mg/kg (max 80mg) 6-12H if required.

### Propylthiouracil 50mg/m2 8H oral, reduce with response.

### Proscillaridin 10-15mcg/kg (adult 500-750mcg) 8-12H oral.

### Prostacyclin See epoprostenol.

### Prostaglandin See alprostadil (PGE1), carboprost (15-Me-

### PGF2-alpha), dinoprost (PGF2-alpha), dinoprostone (PGE2),

### epoprostenol (PGI2, prostacyclin), gemeprost (PGE1 analogue),

### and misoprostol (PGE1 analogue).

### Protamine IV 1mg/100u heparin (0.5mg/100u if >1hr since

### heparin dose) slow IV stat; subsequent doses of protamine 1mg/kg

### (max 50mg). 1mg per 25ml pump blood. Heparin 1mg=100u (half

### life 1-2hr).

### Protein C, activated See drotrecogin alfa.

### Prothionamide TB: 15-20mg/kg (adult 0.75-1g) at night oral.

### Leprosy: 5-8mg/kg (adult 250-375mg) daily.

### Prothrombinex See coagulation factor, human.

### Protionamide See prothionamide.

### Protirelin NOT/kg: 200mcg IV stat.

### Protriptyline 0.1-0.4mg/kg (adult 5-20mg) 6-8H oral.

### Proxymetacaine 0.5% soltn: 1 drop/eye stat, then 1 drop every

### 10min for 5-7 doses.

### Pseudoephedrine 1mg/kg (adult 60mg) 6-8H oral. Slow release:

### adult (NOT/kg) 120mg 12H.

### Pseudoephedrine 60mg + triprolidine 2 5mg (Actifed). 10ml

### elixir=1tab. NOT/kg: 2.5ml (<2yr), 2.5-5ml (2-5yr), 0.5tab (6-12yr),

### 1tab (>12yr) 6-8H oral.

### Psyllium Usually 0.1-0.2g/kg (adult 5-10g) 8-24H oral.

### Pumactant (ALEC) Preterm babies (NOT/kg): disconnect ETT,

### rapidly inject 100mg in 1ml saline via catheter at lower end ETT,

### flush with 2ml air; repeat after 1hr and 24hr. Prophylaxis if

### unintubated: 100mg into pharynx.

### Pyrantel Threadworm: 10mg/kg (adult 750mg) once oral, may

### repeat 2wkly x3 doses. Roundworm, hookworm: 20mg/kg (adult 1g)

### once, may repeat in 7 days. Necator: 20mg/kg (adult 1g) daily x2-3

### doses.

### Pyrazinamide 20-35mg/kg (max 1.5g) daily oral, or 75 mg/kg

### (max 3g) x2/wk.

### Pyrethrins + piperonyl butoxide Lice: apply enough shampoo to wet

### hair, wash off in 15min; repeat in 10 days.

### Pyridostigmine Myas gravis: 1mg/kg (adult 60mg) 4-6H oral, incr

### to max 2-3mg/kg (adult 120-180mg) 4-6H if reqd. 180mg slow rel

### tab (Timespan), adult (NOT/kg): 1-3 tab 12-24H oral. 1mg IV, IM or

### SC = 30mg oral.

### Pyridoxine With isoniazid or penicillamine (NOT/kg): 5-10mg

### daily IV or oral. Fitting: 10-15mg/kg daily IV or oral. Siderobl

### anaemia: 2-8mg/kg (max 400mg) daily IV or oral.

### Pyrilamine See mepyramine.

### Pyrimethamine Adult (NOT/kg): 25mg tab weekly oral.

### Pyrimethamine 25mg + sulphadoxine 500mg (Fansidar) <4yr tab

### once, 4-8yr 1 tab, 9-14yr 2 tab, >14yr 3 tab. Prophylaxis: <4yr tab

### wkly, 4-8yr tab, 9-14yr tab, >14yr 1 tab. See also dapsone +

### pyrimethamine.

### Q fever vaccine (Q-Vax) See Coxiella burnetti vaccine.

### Quazepam 0.15-0.6mg/kg (adult 15-30mg) at night oral.

### Quetiapine Adult (NOT/kg) 12H oral per dose: 25mg day 1, 50mg

### day 2, 100mg day 3, 150mg day 4, then 150-250mg (range 75-

### 400mg) 12H.

### Quinagolide 0.5mcg/kg (adult 25mcg) nocte, incr to 1.5-3 mcg/kg

### (adult 75-150mcg) nocte oral.

### Quinalbarbitone Sedative 5mg/kg. Premed 10mg/kg.

### Quinapril 0.2-0.8mg/kg (adult 10-40mg) daily oral. See also

### hydrochlorothiazide.

### Quinidine, base 10mg/kg stat, then 5mg/kg (max 333mg) 4-6H

### oral. IV: 6.3mg/kg (10mg/kg of gluconate) over 2hr, then

### 0.0125mg/kg/min. IM: 15mg/kg stat, then 7.5mg/kg (max 400mg)

### 8H. NOTE: 1mg base = 1.2mg sulphate = 1.3mg bisulphate =

### 1.6mg gluconate.

### Quinine, base Oral: 8.3mg/kg (max 500mg) 8H for 7-10 days.

### Parenteral: 16.7mg/kg (20mg/kg of dihydrochloride) IV over 4hr or

### IM, then 8.3mg/kg 8H IV over 2hr or IM for 2-3 days, then 8.3mg/kg

### 8H oral for 5 days. NOTE: 1mg base = 1.7mg bisulphate = 1.2mg

### dihydrochloride

### Quinupristin See dalfopristin + quinupristin.

### Rabeprazole 0.4mg/kg (adult 20mg) daily oral. H pylori: 20mg +

### clarithromycin 0.5g + amoxycillin 1g all 12H 1wk.

### Rabies vaccine, inactivated (Rabipur) 1ml IM stat, 7 days later,

### and 28 days later (3 doses). Boost every 2yr. Postexposure:

### immune, 1ml IM day 0 and day 3; non-immune, give 1ml IM on

### days 0,3,7,14,30 and 90, with immunoglobln.

### Raloxifene 1mg/kg (adult 60mg) daily oral.

### Raltegravir Adult (NOT/kg): 400mg 12H oral.

### Raltitrexed Initially 3mg/m2 IV over 15min every 3wk.

### Ramipril 0.05mg/kg (adult 2.5mg) oral daily, may incr over 4-6wk to

### 0.1-0.2mg/kg (adult 5-10mg) daily.

### Ranitidine IV: 1mg/kg (adult 50mg) slowly 6-8H, or 2mcg/kg/min.

### Oral: 2-4mg/kg (adult 150mg) 8-12H, or 300mg (adult) at night.

### Ranitidine bismuth citrate 8mg/kg (adult 400mg) 12H oral; to

### eradicate H.pylori, add antibiotics.

### Rapacuronium Initially 2mg/kg (child), 1.5mg/kg (adult),

### 2.5mg/kg Caesar); maintenance 33-50% initial.

### Rabeprazole Adult (NOT/kg): 20mg daily oral 4-8wk (DU), 6-12wk

### (GU), 4wk then 10-20mg daily (reflux). ZE: 60mg daily, incr if reqd

### to 12H. H.pylori: 20mg + clarithromycin 500mg + amoxicillin 1g all

### 12H for 7 days.

### Ramelteon 8mg oral at bedtime.

### Ranibizumab 0.5mg by intravitreous injection every month.

### Ranolazine Adult (NOT/kg): 0.5-1g 12H oral.

### Rasagiline Adult (NOT/kg): 0.5-1mg daily oral.

### Rasburicase 0.15-0.2mg/kg IV daily for 5-7 days.

### Razoxane 2mg/kg (max 125mg) 8-24H oral; or 7.5-15mg/kg

### (max 750mg) daily for 2-3 days every 1-4wk. Kaposi sarc,

### leukaemia: max 0.33g/m2 8H oral.

### Reboxetine Adult (NOT/kg): 2-4mg 12H oral, incr gradually if reqd

### to max 10mg 12H.

### Recombinant antihaemophilic factor See factor 8.

### Remifentanil 0.05-0.2mcg/kg/min. Ventilated: usually 0.5-1

### mcg/kg/min; occasionally up to 8mcg/kg/min if reqd.

### Repaglinide Adult (NOT/kg) before main meals, oral: initially

### 0.5mg, incr every 1-2wk to 4mg (max 16mg/day).

### Reproterol Aerosol 0.5mg/puff: 1-2 puffs 3-8H.

### Reserpine 0.005-0.01mg/kg (adult 0.25-0.5mg) 12-24H oral.

### Residonrate Adult (NOT/kg): 5mg daily oral; slow release 35mg

### once a week.

### Resonium See sodium polystyrene sulphonate.

### Retapamulin 1% ointment: apply 12H for 5 days.

### Reteplase Adult (NOT/kg) for myocard infarct: give heparin

### 5000u IV + aspirin 250-350mg oral; then reteplase 10u IV over

### 2min + 2nd dose 30min later; then heparin 1000u/hr for 24-72hr

### and aspirin 75-150mg/day until discharge.

### Retinol A See vitamin A.

### Reviparin Child >2mo: 100u/kg 12H SC. Adult (NOT/kg): 1432u

### 2hr before surgery, then daily SC.

### Ribavirin Inhltn (Viratek nebulizer): 20mg/ml at 25ml/hr (190mcg/l of

### gas) for 12-18hr/day for 3-7 days. Oral: 5-15mg/kg 8-12H. Hepatitis

### C: see interferon alfa-2b.

### Riboflavine NOT/kg: 5-10mg daily oral. Organic acidosis

### (NOT/kg): 50-200mg daily oral, IM or IV.

### Rifabutin Pulmonary TB: 3-5 mg/kg (adult 150-300mg) daily oral.

### Resistant pul TB: 5-7.5 mg/kg (adult 300-450mg) daily. Mycobact

### avium complex: 7.5-12mg/kg (adult 450-600mg) daily; prophylaxis

### 5mg/kg (adult 300mg) daily.

### Rifampicin 10-15mg/kg (max 600mg) daily oral fasting, or IV over

### 3hr (monitor AST). Prophylaxis: N.meningitidis 10 mg/kg daily

### (neonate), 10 mg/kg (max 600mg) 12H for 2 days; H.influenzae

### 10mg/kg daily (neonate), 20mg/kg (max 600mg) daily for 4 days.

### Rifampin See rifampicin.

### Rifapentine Usually 10-15 mg/kg (adult 600mg) x2/wk for 2mo,

### then wkly for 4 months.

### Rifaximin Adult (NOT/kg): 200mg 8H for 3 days.

### Riluzole 1mg/kg (adult 50mg) 12H oral.

### Rimantadine 2.5mg/kg (adult 100mg) 12H oral.

### Rimexolone 1%. 1drop/eye 6H. Uveitis: 1drop 1H in daytime for

### 1wk, 2H for 1wk, 6H for 1wk, daily 1wk.

### Rimonabant Adult (NOT/kg): 20mg oral before breakfast.

### Risedronate Osteoporosis: 0.1mg/kg (adult 5mg) daily oral; slow

### release 35mg (adult) weekly. Paget's: 0.5mg/kg (adult 30mg) daily

### oral.

### Risperidone 0.02mg/kg (adult 1mg) 12H, incr if reqd to 0.15mg/kg

### (adult 2-4mg, max 8mg) 12H oral.

### Ritodrine Prem labour (NOT/kg): 50mcg/min, incr to 150-

### 350mcg/min IV; then oral 10mg 2H for 24hr, 10-20mg 4-6H.

### Ritonavir 250mg/m2 (adult 300mg) 12H, incr over 5 days if toleratd

### to 400mg/m2 (infant 450mg/m2, adult 600mg) 12H oral. See also

### lopinavir.

### Rituximab Leukaemia: 260-370mg/m2 by IV infsn wkly x4.

### Rheumatoid arthritis (adult, NOT/kg): 1g IV twice, 2wk apart.

### Rivastigmine Adult (NOT/kg): initially 1.5mg 12H, incr every 2wk to

### max 6mg 12H oral. Patch: apply 4.6mg (5cm2) daily for 4wk, then

### 9.5mg (10cm2) daily.

### Rizatriptan Adult (NOT/kg): 10mg oral, may repeat x1 in 2hr. .

### Rocuronium 0.6-1.2mg/kg IV stat, then 0.1-0.2mg/kg boluses or 5-

### 15mcg/kg/min.

### Ropinirole Adult (NOT/kg): 0.25mg daily for 2 days, 0.5mg for 5

### days, then 1mg daily; incr wkly to max 4mg daily oral. Restless

### legs: 0.25mg (max 4mg) 2hr before bedtime.

### Ropivacaine 4-5mg/kg (adult max 200-250mg). Intrathecal: 1mg/kg

### (0.1ml/kg of 1%). Postop infusion 0.2-0.4mg/kg/hr (0.1-0.2ml/kg/hr

### of 0.2%).

### Rosiglitazone Adult (NOT/kg): 4mg daily oral, incr after 6-8 wk

### to 4mg 12H if reqd. See also glimepiride + rosiglitazone.

### Rosuvastatin 10mg daily oral, incr if reqd to 20mg then 40mg at

### 4wk intervals.

### Rotavirus vaccine, human (Rotarix) Live, monovalent. 1ml oral at 6-

### 14wk, and at least 4wk later at 14-24wk (2 doses).

### Rotavirus vaccine, human-bovine (RotaTeq) Live, penta-valent.

### 2ml oral at age 2mo, 4mo, 6mo (3 doses).

### Rotigotine Adult, NOT/kg: 2mg patch daily for 1wk, then 4mg

### daily; incr if reqd to 6mg daily.

### Roxithromycin 2.5-4mg/kg (adult 150mg) 12H oral.

### Rubella vaccine (Ervevax, Meruvax II) Live >12mo: 0.5ml SC

### once. See also measles + mumps + rubella vaccine.

### Salbutamol (and levalbuterol) 0.1-0.15mg/kg (adult 2-4mg) 6H

### oral. Inhaltn: mild resp soltn (5mg/ml, 0.5%) 0.5ml diluted to 4ml, or

### nebule 2.5mg/2.5ml 3-6H; moderate 0.5% soltn 1ml diluted to 4ml,

### or nebule 5mg/2.5ml 1-2H; severe (in ICU) 0.5% soltn undiluted

### continuous. Aerosol 100mc

### Salcatonin Hypercalcaemia: 5u/kg 12-24H IM, SC or IV over 6-

### 12hr. Paget's: adult 50-100u daily. Cancer bone pain: 4u/kg (adult

### 200u) up to x4/day.

### Salicylic acid Cradle cap: 6% soltn (Egocappol) 12H 3-5 days.

### Plantar warts: 15% soltn x1-2/day, 40% medicated disc 24-48H.

### See also benzoic acid + salicylic acid.

### Salicylsalicylic acid See salsalate.

### Salmeterol Aerosol, diskhaler (NOT/kg): 50-100mcg 12H. See

### also fluticasone + salmeterol.

### Salmonella typhi vaccine See typhoid vaccine.

### Salsalate 10-20mg/kg (adult 0.5-1g) 6H oral.

### Saquinavir Soft gel caps preferred. Child: 50mg/kg 8H oral;

### 33mg/kg 8H with nelfinavir. Adult (NOT/kg): 1200mg 8H, or

### 1600mg 12H oral.

### Saracenia purpurea (Sarapin) Adult (NOT/kg): 2-10ml nerve block,

### 5-10ml local infiltration.

### Sargramostim (GM-CSF, Leucomax) 3-5mcg/kg daily SC, or IV

### over 6hr. Keep WCC 5,000-10,000/mm3.

### Scopolamine See hyoscine hydrobromide.

### Secbutobarbitone 0.3-0.6mg/kg (adult 15-30mg) 6-8H, or 1-4mg/kg

### (adult 50-200mg) nocte oral.

### Secobarbital sodium See quinalbarbitone.

### Selegiline Adult (NOT/kg): 10mg daily, oral. Transdermal patch:

### 6mg daily; incr to max 9-12mg daily if reqd.

### Selenium sulphide 2.5% shampoo x2/wk for 2wk.

### Senna, Sennoside Tab 7.5mg, granules 15mg/5ml. Daily

### (NOT/kg): 6mo-2yr 7.5mg, 3-10yr 7.5-15mg, >10yr 1-30mg.

### Sermorelin (GHRH) 1mcg/kg fasting in morning IV.

### Sertaconazole 2% cream: apply 12H for 4wk.

### Sertindole Adult 4mg daily, incr to 12-24mg daily oral.

### Sertraline 0.5mg/kg (adult 25mg) daily oral, incr if reqd to 1-

### 2mg/kg (adult 50-100mg) daily; may give 3-4mg/kg (adult 150-

### 200mg) daily for up to 8wk.

### Sevelamer 20-40mg/kg (adult 800-1600mg) 8H oral, titrated to

### serum phosphorus.

### Sibutramine Adult (NOT/kg): usually 10mg (range 5-15mg) daily

### oral. .

### Sildenafil Adult sexual dysfunction: 25-100mg (NOT/kg) oral 1hr

### before sexual activity (max once/day). Pul hypertension: 0.3mg/kg

### 3-6H incr until effective or systemic hypotension occurs (usual max

### 2-3 mg/kg/dose); adult (NOT/kg) usually 20mg 8H oral. 1hr before

### sto

### Silver nitrate, stick Apply daily to affected area only.

### Silver sulfadiazine 1% + chlorhexidine 0.2% Cream: apply in 3-

### 5mm layer.

### Simethicone See aluminium hydroxide compound.

### Simvastatin Adult (NOT/kg): 10mg daily oral, incr if reqd every

### 4wk to max 80mg daily.

### Sinecatechins 15% ointment: apply 8H for up to 16wk.

### Sirolimus 3mg/m2 (adult 6mg) stat, then 1mg/m2 (adult 2mg)

### daily oral.

### Sitagliptin 2mg/kg (adult 100mg) daily oral.

### Sitaxentan 2mg/kg (adult 100mg) daily oral.

### Sodium Deficit (ml saline) = Wt(kg) x 4 x (140 - [Na]) / % saline. To

### incr serum Na by 0.5mmol/L/hr (max safe rate), infusn rate (ml/hr) =

### 2 x Wt(kg) / (% saline infused); hours of infusion = 2 x (140 - serum

### Na). 4ml/kg of X% saline raises serum Na by Xmmol/L.

### Sodium alginate See alginic acid.

### Sodium aurothiomalate 0.25mg/kg wkly IM, incr to 1 mg/kg (max

### 50mg) wkly for 10wk, then every 2-6wk.

### Sodium benzoate Neonate: 250mg/kg over 2hr stat, then 10-

### 20mg/kg/hr IV.

### Sodium bicarbonate See bicarbonate.

### Sodium calcium edetate (EDTA) 25-40mg/kg 12H IM or IV over

### 1hr for 5 days; repeat after 3 days if reqd. With dimercaprol:

### 12.5mg/kg 4H for 3-7 days.

### Sodium cellulose phosphate (Calcisorb) Adult: 5g (NOT/kg) 8H

### oral.

### Sodium citrate Constipation (adult, NOT/kg): usually 450mg in

### 5ml as enema, often with sodium lauryl sulphoacetate, glycerol,

### sorbitol or sorbic acid.

### Sodium citrotartrate 40-80mg/kg (adult 2-4g) in 50ml water 8-12H

### oral.

### Sodium clodronate See clodronate.

### Sodium cromoglycate Inhalation (Intal): 1 cap (20mg) 6-8H, 2ml

### soltn (20mg) 6-8H, aerosol 1-10mg 6-8H. Eye drops 2%: 1

### drop/eye 4-6H. Oral: 5-10mg/kg (max 200mg) 6H oral. Nasal 2% or

### 4%: 1 dose to each nostril 3-12H.

### Sodium ferric gluconate Fe 12.5mg/ml. 0.05ml/kg (adult 2ml) test

### dose IV over 1hr, then 0.25ml/kg (adult 10ml) IV over 1hr with each

### dialysis (usually for 8 doses). .

### Sodium fluoride NOT/kg: <2yr 0.55mg oral daily, 2-4yr 1.1 mg,

### >4yr 2.2mg. Osteoporosis, Paget's, bone secondaries in adult

### (NOT/kg): 20-40mg 8-12H.

### Sodium fusidate Tablets: 10-15mg/kg (adult 250-500mg) 8H oral.

### IV over 2-8hr: 10mg/kg (adult 500mg) 8H; severe inftn 15mg/kg

### (adult 750mg). Peak level 30-200umol/L (x0.52 = mcg/ml). For

### suspension, see fusidic acid.

### Sodium hyaluronate Adult (NOT/kg). Cystitis 800mcg/ml: 50ml

### into bladder wkly x4, then 4wkly. Ophthalmic: 10-15 mg/ml (1-1.5%)

### 0.2-0.6ml into anterior chamber; 0.18% drops 1/eye as reqd.

### Osteoarthritis 10-15mg/ml: 2-2.5ml intra-articular wkly x3-5.

### Sodium nitrite 3%: 0.2ml/kg (max 10ml) IV over 5 min.

### Sodium nitroprusside <30kg: 3mg/kg in 50ml 5%dex-hep at 0.5-

### 4ml/hr (0.5-4mcg/kg/min) IV. >30kg: 3mg/kg made to 100ml in

### 5%dex-hep at 1-8ml/hr (0.5-4mcg/kg/min). If used for >24hr, max

### rate 4mcg/kg/min. Max total 70mg/kg with normal renal function (or

### sodium thiocyanate <1725

### Sodium oxybate Narcolepsy (NOT/kg): 2.25g at bedtime, repeated

### 2-4hr later; incr if reqd by 0.75g every 2wk to max 4.5g + 4.5g (9g

### per night).

### Sodium phenylbutyrate 10-13g/m2/day divided into equal

### amounts with each feed or meal, oral.

### Sodium phosphate See phosphate, sodium.

### Sodium picosulphate 2.5mg (1-4yr), 2.5-5mg (4-10yr), 5-10mg

### (>10yr) at night oral.

### Sodium polystyrene sulphonate (Resonium) 0.3-1 g/kg (adult 15-

### 30g) 6H NG (give lactulose) or PR.

### Sodium stibogluconate Soltn 100mg/ml of pentavalent

### antimony. 20mg/kg (usual max 850mg) daily IV over 5-10min for 20

### days (visceral) or at least 4wk (mucocutaneous); 10-15mg/kg 12H if

### toxicity or poor response. Early cutaneous: infiltrate lesions with 1-

### 3ml, repeat x1-2 if req

### Sodium tetradecyl sulphate NOT/kg: 0.25-1ml per vein as 1%

### (max 10 small veins) or 3% (max 4 large veins).

### Sodium thiosulphate 1ml/kg (adult 50ml) 25% soltn IV over 10min.

### Sodium valproate 5mg/kg (adult 200mg) 8-12H oral, incr if reqd to

### max 20mg/kg (adult 1g) 8-12H. Level 2hr after dose 300-700umol/l

### (x0.14=mg/l).

### Solifenacin Adult (NOT/kg): 5-10mg daily oral.

### Somatostatin See octreotide.

### Somatrem 4u/m2 3 days a wk IM.

### Somatropin 1mg = 3iu. Usually 2-3iu/m2 on 5-7 days a wk SC, or

### 4-6iu/m2 on 3 days a wk IM.

### Sorafenib Adult (NOT/kg): 400mg 12H (or 24-48H) oral.

### Sorbitol 70% 0.2-0.5ml/kg (adult 20-30ml) 8-24H oral. With

### activated charcoal: 1g/kg (1.4ml/kg) NG, x1-2.

### Sorbolene cream; pure, with 10% glycerin, or with 5% or 10% olive

### oil or peanut oil Skin moisturiser: apply prn.

### Sotalol IV: 0.5-2mg/kg (adult 25-120mg) over 10min 6H. Oral: 1-

### 4mg/kg (adult 50-160mg) 8-12H.

### Sparfloxacin 10mg/kg (adult 400mg) stat, then 5mg/kg (adult

### 200mg) daily oral.

### Spectinomycin 40-80mg/kg (adult 2-4g) IM once.

### Spironolactone Oral (NOT/kg): 0-10kg 6.25mg 12H, 11-20kg

### 12.5mg 12H, 21-40kg 25mg 12H, over 40kg 25mg 8H. Female

### hirsutism 50mg 8H. IV: see potassium canrenoate.

### Stanolone 2.5% gel. Male: apply 5-10g daily to a large area of

### skin and allow 5 min to dry. Female (lichen sclerosus): apply 2.5g

### to vulva on alternate days.

### Stanozolol 0.05-0.2mg/kg oral (adult 2.5-10mg) daily at first, then

### every 2-3 days.

### Stavudine (d4T) 1mg/kg (<30kg), 30mg (30-60kg), 40mg (>60kg)

### 12H oral. Slow rel (adult, NOT/kg): 75mg (<60kg), 100mg (>60kg)

### daily oral.

### Sterculia NOT/kg: 3.5-7g 12-24H oral.

### Stibogluconate See sodium stibogluconate.

### Stilboestrol Ca breast (NOT/kg): 10-20mg daily oral. Ca prostate:

### 1-3mg daily oral or IV. .

### Streptokinase (SK) Short term (myoc infarct): 30,000u/kg (max

### 1,500,000u) IV over 60min, repeat if occlusion recurs <5 days.

### Long term (DVT, pul emb, art thrombosis): 2,000 u/kg (max

### 100,000u) IV over 10min, then 1000u/kg/hr (max 100,000u/hr); stop

### heparin and aspirin, if P

### Streptomycin 20-30mg/kg (max 1g) IM daily.

### Strontium ranelate Adult, NOT/kg: 2g daily at bedtime.

### Succimer 350mg/m2 8H for 5 days, then 12H x14 days oral.

### Succinyl choline See suxamethonium.

### Sucralfate 1g tab (NOT/kg): 0-2yr quarter tab 6H, 3-12 yr half tab

### 6H, >12yr 1 tab 6H oral.

### Sucrose Analgesia in infants: 0.17g/kg (0.5ml/kg of 33% soltn)

### 2min before procedure.

### Sufentanil 2-50mcg/kg slow IV; may then infuse so that total

### dose is 1mcg/kg/hr of expected surgical time. .

### Sulbactam See ampicillin + sulbactam.

### Sulconazole 1% cream: apply 12H for 3wk after clinical cure.

### Sulfacetamide See sulphacetamide.

### Sulfadiazine 50mg/kg (max 2g) 6H slow IV.

### Sulfadoxine See pyrimethamine + sulphadoxine.

### Sulfamethizole See sulphamethizole.

### Sulfamethoxazole + trimethoprim See cotrimoxazole.

### Sulfametopyrazine 40mg/kg (adult 2g) wkly oral.

### Sulfasalazine See sulphasalazine.

### Sulfinpyrazone See sulphinpyrazone.

### Sulfisoxazole See sulphafurazole.

### Sulindac 4mg/kg (adult 200mg) 12H oral.

### Sulphacetamide 100mg/ml 1 drop/eye 2-3H during the day.

### Sulphadoxine See pyrimethamine + sulphadoxine.

### Sulphafurazole 75mg/kg (adult 4g) stat, then 35mg/kg (adult

### 1.5g) 4-6H oral.

### Sulphamethizole 10mg/kg (adult 0.5-1g) 6H oral.

### Sulphamethoxazole + trimethoprim See cotrimoxazole.

### Sulphasalazine Active colitis: 20mg/kg 6-12H (max 4g/day) oral;

### remission 7.5mg/kg (max 0.5g) 6-8H, suppos (NOT/kg) adult 0.5-1g

### 12H. Arthritis: 5mg/kg 12H, incr if reqd to 10mg/kg 8-12H (max

### 2g/day).

### Sulphinpyrazone 2-3mg/kg (max 200mg) 6-12H oral.

### Sulpiride 4mg/kg (adult 200mg) 12H, slow incr if reqd to 4-24mg/kg

### (adult 0.2-1.2g) 12H oral.

### Sulthiame 1mg/kg (adult 50mg) 8-12H oral, may incr to 5mg/kg

### (adult 200mg) 8H.

### Sumatriptan Oral: 1-2mg/kg (adult 50-100mg) stat, may repeat

### twice. SC: 0.12mg/kg (max 6mg) stat, may repeat once after 1hr.

### Nasal: 10-20mg, may repeat x1 after 2hr.

### Sunitinib Adult (NOT/kg): 50mg (37.5-87.5mg) daily oral for 4wk,

### then 2wk off.

### Surfactant See beractant (Survanta), calfactant (Infasurf),

### colfosceril palmitate (Exosurf), poractant alfa (Curosurf), pumactant

### (ALEC).

### Suxamethonium IV: neonate 3mg/kg, child 2mg/kg , adult 1mg/kg.

### IM: double IV dose.

### Tacrine Adult (NOT/kg): 10mg 6H oral for 6wk, then incr if reqd by

### 10mg every 6wk to max 40mg 6H. .

### Tacrolimus IV infusion: 2mg/m2/day. Oral: 3mg/m2 12H. Trough

### level: whole blood 10-15ng/ml (sent to Austin daily at 1000 from

### RCH). .

### Tacrolimus ointment 2-16yr: apply 0.03% sparingly 12H for max

### 3wk, then daily. >16yr: apply 0.1% sparingly 12H for max 3wk, then

### 0.03% 12H.

### Tadalafil Adult (NOT/kg): 10mg (range 5-20mg) oral 30min before

### sex (max x1/day), or 2.5mg (max 5mg) every day.

### Tamoxifen Adult (NOT/kg): 20mg daily, incr to 40mg daily if no

### response after 1mo.

### Tamsulosin Adult 400mcg daily after breakfast oral.

### Tar See coal tar.

### Tazarotene 0.05%, 0.1% gel, cream: apply a thin layer to affected

### area daily (or on alternate days) in the evening.

### Tazobactam See piperacillin + tazobactam.

### Tegafur 100mg + uracil 224mg 100mg/m2 tegafur + 224 mg/m2

### uracil (with 30mg calcium folinate) 8H oral for 28 days, 7 days off,

### then repeat cycle.

### Tegaserod Adult (NOT/kg): 6mg 12H for 4-12wk oral.

### Teicoplanin 250mg/m2 IV over 30min stat, then 125mg/m2 IV or

### IM daily. Severe inftn: 250mg/m2 12H x3 doses, then 250mg/m2 IV

### or IM daily.

### Telbivudine Adult (NOT/kg): 600mg daily oal.

### Telithromycin Adult (NOT/kg): 800mg oral daily.

### Telmisartan 1mg/kg (adult 40mg) daily, incr if reqd to 2 mg/kg

### (adult 80mg) daily oral.

### Temazepam 0.3mg/kg (adult 20-40mg) oral.

### Temocillin 25-50mg/kg (adult 1-2g) 12H IV or IM.

### Temoporfin 150mcg/kg IV over 10min; 96hr later give 652 nm

### laser for about 200 sec to give 20J/cm2; repeat once after 4wk if

### reqd.

### Temozolomide 200mg/m2 daily oral for 5 days per 28 day cycle

### (150mg/m2 for first cycle if previous chemotherapy).

### Temsirolimus Adult, NOT/kg: 25mg IV over 1hr wkly.

### Tenecteplase 1mg = 200u. Myocar infarct (adult): 100u/kg (max

### 10,000u) IV over 10sec once; also give aspirin 150-325mg/day, and

### heparin to maintain APTT 50-75sec.

### Tenofovir disoproxil fumarate 300mg of tenofovir DF = 245mg

### tenofovir D. Adult (NOT/kg): 300mg daily oral.

### Tenoxicam 0.2-0.4mg/kg (adult 10-20mg) daily oral.

### Terazosin 0.02mg/kg test, then 0.04-0.4mg/kg (adult 2-20 mg)

### daily oral.

### Terbinafine 62.5mg (<20kg), 125mg (20-40kg), 250mg (adult)

### daily oral. 1% cream, gel: apply 12-24H to dry skin.

### Terbutaline Oral: 0.05-0.1mg/kg (adult 2.5-5mg) 6H. SC: 5-

### 10mcg/kg (adult 0.25-0.5mg). IV: child 3-6mcg/kg/min for 1hr, then

### 0.4-1mcg/kg/min; adult 0.25mg stat over 10min, then 1-

### 10mcg/kg/hr. Inhaltn: mild resp soltn (1%, 10mg/ml) 0.25ml diluted

### to 4ml 3-6H; moderate

### Terfenadine 30mg (6-12yr), 60mg (adult) 12H oral.

### Teriparatide Adult (NOT/kg): 20mcg SC daily.

### Terlipressin 0.04mg/kg (adult 2mg) IV, then 0.02-0.04mg/kg (adult

### 1-2mg) 4-6H for max 72hr. Slow onset, long action: continuous

### infsn may cause necrosis.

### Testolactone 5-10mg/kg (max 250mg) 6H oral.

### Testosterone Esters (NOT/kg): 100-500mg IM every 2-4wk.

### Implant: 8mg/kg (to nearest 100mg) every 16-24wk. Undecanoate

### (NOT/kg): 40mg daily oral, incr to 80-120mg daily. 1% gel: 5g tube

### (50mg testosterone) to skin daily. 30mg buccal tab: applied just

### above incisor 12H.

### Tetanus toxoid (Tet-Tox) 0.5ml IM stat, 6wk later, and 6mo later.

### Boost every 10yr, or if contaminated wound. See also diphtheria (+

### pertussis) + tetanus vaccines.

### Tetrabenazine 0.5-2mg/kg (adult 25-100mg) 12H oral.

### Tetracaine See amethocaine.

### Tetracosactrin zinc injection (Synacthen Depot) 600 mcg/m2

### (max 1mg) IM every 1-7 days.

### Tetracycline >8yr (NOT/kg): 250-500mg 6H oral. Acne (NOT/kg):

### 500mg 12H, reducing to 250mg 12H. Eye: apply 2-8H. See also

### rolitetracycline.

### Tetrahydrobiopterin Defective synthesis: 20mg/kg daily oral.

### Defective regeneration: 5mg/kg 6H oral. Loading test: 20mg/kg

### oral, 2mg/kg IV.

### Tetrahydrozoline 0.05%: 1 drop/eye 8-12H. See also macrogol +

### tetrahydrozoline.

### Thalidomide 4mg/kg (adult 200mg) 12H oral, reducing over 2-4wk

### to 0.5-1mg/kg (adult 25-50mg) 12H.

### THAM See trometamol.

### Theophylline 80mg theophylline = 100mg aminophylline). Loading

### dose: 8mg/kg (max 500mg) oral. Maintenance: 1st wk life 2mg/kg

### 12H; 2nd wk 3mg/kg 12H; 3wk-12mo ((0.1 x age in wk) + 3) mg/kg

### 8H; 1-9yr 4mg/kg 4-6H, or 10mg/kg slow rel 12H; 10-16yr or adult

### smoker 3mg/kg

### Thiabendazole 25mg/kg (max 1.5g) 12H oral 3 days.

### Thiamine Beriberi: 1-2mg/kg IV, IM or oral daily. Metabolic dis

### (NOT/kg): 100mg 8H IV, IM, SC, oral.

### Thiethylperazine maleate >10kg: 0.2mg/kg (adult 10mg) 8-24H

### oral, IM, or PR.

### Thioguanine 100mg/m2 daily oral; or 100mg/m2 12H for 5-7 days.

### Thiopental See thiopentone.

### Thiopentone 2-5mg/kg slowly stat (beware hypotension). IV infsn:

### amp 25mg/ml at 0.04-0.2ml/kg/hr (1-5mg/kg/hr). Level 150-

### 200umol/L (x0.24 = mcg/ml).

### Thioridazine 0.5-3mg/kg (adult 25-150mg) 6-8H oral or IM.

### Thiosulphate See sodium thiosulphate.

### Thiotepa 10-14mg/m2 IV every 1-4wk.

### Thiotepa 1 in 2000: 1 drop/eye 4-6H for 6wk.

### Thiothixene >12yr (NOT/kg): initially 2mg 8H oral, slow incr to 2-

### 20mg per dose.

### Threonine 15-30mg/kg (adult 0.75-1.5g) 8H oral.

### Thrombin glue 10,000u thrombin in 9ml mixed with 1ml 10%

### calcium chloride in syringe 1, 10ml cryoprecipitate in syringe 2:

### apply to bleeding sites together. Do not inject.

### Thrombin, topical 100-2000u/ml onto bleeding surface.

### Thymoxamine Adult (NOT/kg): 40-80mg 6H oral.

### Thyrotropin alfa Adult (NOT/kg): 0.9mg IM 24H x2 doses, or 72H

### x3 doses.

### Thyroxine 50mcg tab. 100mcg/m2 rounded to nearest quarter

### tab (adult 100-200mcg) daily oral.

### Tiagabine Usually 0.1mg/kg (adult 5mg) 12H, incr wkly to 0.1-

### 0.5mg/kg (adult 5-15mg) 8H oral.

### Tiaprofenic acid 2-4mg/kg (adult 100-200mg) 8H oral.

### Tibolone Adult (NOT/kg): 2.5mg daily oral.

### Ticarcillin 50mg/kg (adult 3g) IV 6-8H (1st wk life), 4-6H or

### constant infsn (2+ wk). Cystic fib: 100mg/kg (max 6g) 8H IV.

### Ticarcillin + clavulanic acid Dose as for ticarcillin.

### Tick-borne encephalitis vaccine Killed. 0.5ml IM stat, after 4-12wk,

### and after 9-12mo. Boost every 3-6yr.

### Ticlopidine 5mg/kg (adult 250mg) 12H oral.

### Tigecycline 2mg/kg (adult 100mg) IV over 1hr stat, then 1mg/kg

### (adult 50mg) IV over 30min 12H.

### Tilactase 200u/drop: 5-15 drops/L added to milk 24hr before

### use. 3300u/tab: 1-3tabs with meals oral.

### Tiludronate disodium Adult 400mg daily for 12 wk oral.

### Tiludronic acid See tiludronate disodium.

### Timolol 0.1mg/kg (adult 5mg) 8-12H, incr to max 0.3mg/kg (adult

### 15mg) 8H. Eye drops (0.25%, 0.5%): 1 drop/eye 12-24H; see also

### bimatoprost + timolol, latanoprost + timolol.

### Timolol 5mg/ml + travoprost 40mcg/ml 1drop/eye daily.

### Tinidazole Giardia, trichomonas: 50mg/kg (adult 2g) daily for 2

### days oral, or 25mg/kg (adult 1g) daily x5 days. Amoebiasis:

### 50mg/kg (adult 2g) daily for 3-5 days, usually followed by diloxanide

### furoate 10mg/kg (adult 500mg) 8H for 10 days.

### Tinzaparin 1mg = 75 anti-Xa IU. Prophylaxis: 50u/kg SC 2hr

### before surgery, then daily for 7-10 days. Treatment: 175u/kg SC

### daily for at least 6 days.

### Tioconazole 280mg/ml: apply to nails 12H for 6-12mo.

### Tioguanine Usually 200mg/m2 daily oral for 5-20 days.

### Tiopronin 3-10mg/kg (adult 150-500mg) 6-8H oral.

### Tiotropium NOT/kg: 18mcg cap daily by inhaler.

### Tipranavir Adult (NOT/kg): 500mg 12H with food (and ritonavir

### 200mg) oral.

### Tirilazad 1.5mg/kg 6H IV over 30min.

### Tirofiban 0.4mcg/kg/min for 30min, then 0.1mcg/kg/min for 2-5

### days; also give heparin to APTT x2 normal.

### Tissue plasminogen activator See alteplase.

### Tizanidine 0.01mg/kg (adult 0.5mg) 8H, incr gradually to 0.1-

### 0.25mg/kg (adult 6-12mg) 8H oral.

### Tobramycin IV or IM. 1wk-10yr: 8mg/kg day 1, then 6 mg/kg daily.

### >10yr: 7mg/kg day 1, then 5mg/kg (max 240-360mg) daily.

### Neonate, 5mg/kg dose: <1.2kg 48H (0-7 days of life), 36H (8-30

### days), 24H (>30 days); 1.2-2.5kg 36H (0-7 days of life), 24H (>7

### days); term 24H (

### Tocainide 5-10mg/kg (max 400-800mg) 8-12H IV over 30min or

### oral.

### Tocopherol See alpha-tocopheryl acetate, and vitamin E.

### Tolazamide 2-5mg/kg (adult 100-250mg) 6-24H oral.

### Tolazoline Newborn: 1-2mg/kg slowly stat (beware hypotension),

### then 2-6mcg/kg/min (0.12-0.36mg/kg/hr) IV. Note: 1-2mg/kg/hr too

### much (Pediatrics 1986;77:307).

### Tolbutamide Adult (NOT/kg): initially 1g 12H oral, often reducing to

### 0.5-1g daily.

### Tolcapone Adult (NOT/kg): 100mg 8H oral; if no response, try

### maximum dose of 200mg 8H. Monitor ALT and AST.

### Tolfenamic acid 4mg/kg (adult 200mg) oral, may repeat once after

### 2hr. .

### Tolmetin 5-10mg/kg (adult 400-600mg) 8H oral.

### Tolnaftate 1% cream, ointmnt, powdr, soltn: apply 8-12H.

### Tolterodine 0.05mg/kg (adult 2mg) 12H oral. Slow rel: adult 2-

### 4mg daily oral.

### Topiramate 1mg/kg (adult 50mg) 12-24H oral, incr slowly if reqd

### to 4-10mg/kg (adult 100-500mg) 12H.

### Topotecan 1.5mg/m2 daily x5 IV over 30min, repeat every 3wk

### for at least 4 courses. .

### Torasemide 0.1-1mg/kg (adult 5-50mg) daily oral or IV. Rarely up

### to 4mg/kg (adult 200mg) daily in renal failure.

### Toremifene Adult (NOT/kg): 60mg daily oral.

### Torsemide See torasemide.

### Tramadol 2-3mg/kg (adult 50-100mg) stat, then 1-2mg/kg (adult

### 50-100mg) 4-6H (usual max 400mg/day, up to 600 mg/day) oral or

### IV over 3min. IV infusion 2-8mcg/kg/min.

### Tramazoline Nasal: 82mcg each nostril x3-6/day. See also

### dexamethasone + tramazoline.

### Trandolapril 0.01-0.1mg/kg (adult 0.5-4mg) daily oral.

### Tranexamic acid Oral: 15-25mg/kg (adult 1-1.5g) 8H for up to 4

### days. IV: 10-15mg/kg (adult 0.5-1g) 8H.

### Tranylcypromine 0.2mg/kg (adult 10mg) 8-12H oral.

### Trastuzumab 4mg/kg IV over 90min load, then 2mg/kg IV over

### 30min wkly. Early cancer after chemo: 8 mg/kg IV over 90min, then

### 6mg/kg IV over 90min every 3wk.

### Travoprost 40mcg/ml (0.004%): 1drop/eye in evening. See also

### timolol + travoprost.

### Trazodone 1-4mg/kg (adult 50-200mg) 8H oral.

### Treprostinil 1.25ng/kg/min SC infsn, incr each wk by 1.25-

### 2.5ng/kg/min to max 20-60ng/kg/min.

### Tretinoin 22.5mg/m2 12H oral. Cream or lotion 0.05%, gel 0.01%:

### apply daily for 3-4 months, then x1-3/wk.

### Triamcinolone Joint, tendon (NOT/kg): 2.5-15mg stat. IM: 0.05-

### 0.2mg/kg every 1-7 days. Cream or ointment 0.02%, 0.05%: apply

### sparingly 6-8H. Triamcinolone has no mineralcorticoid action, 1mg

### = 5mg hydrocortisone in glucocorticoid action. See also gramicidin

### \+ neomycin

### Triamterene 2mg/kg (adult 100mg) 8-24H oral. See also

### benzthiazide + triamterene.

### Triazolam 0.005-0.01mg/kg (adult 0.125-0.5mg) at night oral. 30

### min preop: 0.01-0.03 mg/kg (adult 0.5mg) oral.

### Tribavirin See ribavirin.

### Triclofos 25-30mg/kg (adult 0.5-1g) at bedtime oral.

### Triclosan 0.5%-5% lotion: 2ml to wet skin for 30sec, rinse and

### repeat. Bath oil: 20ml in 20cm bath, soak 15min.

### Trientine 10mg/kg (adult 500mg) 6-12H oral.

### Triethylenethiophosphoramide See thiotepa.

### Trifluoperazine 0.02-0.4mg/kg (adult 1-10mg, occasionally 20mg)

### 12H oral. Capsule: adult 15mg daily.

### Trifluridine 1% soltn: 1 drop/eye 2H (max 9 drops/day) until

### epithelialised, then 4H (max 5 drops/day) for 7 days.

### Trilostane 0.5-4mg/kg (adult 30-240mg) 6H oral.

### Trimeprazine Antihist: 0.1-0.5mg/kg (adult 2.5-25mg) 6H oral.

### Sedatn: 0.5-1mg/kg IM, 2-4mg/kg oral.

### Trimethobenzamide 5mg/kg (adult 250mg) 6-8H oral,IM,PR.

### Trimethoprim 3-4mg/kg (usual max 150mg) 12H, or 6-8mg/kg

### (usual max 300mg) daily oral or IV. Urine prophylaxis: 1-2mg/kg

### (adult 150mg) at night oral.

### Trimethoprim + sulphamethoxazole See cotrimoxazole.

### Trimethylglycine See betaine hydrochloride.

### Trimetrexate 45mg/m2 IV over 90min daily for 21 days, with folinic

### acid 20mg/m2 IV over 10min 6H for 24 days (ie for 3 days longer

### than the trimetrexate).

### Trimipramine 1-2mg/kg (adult 50-100mg) 8-24H oral.

### Trioxsalen See trioxysalen.

### Trioxysalen Adult: 5-10mg daily 2hr before UV exposure.

### Tripelennamine 1.25mg/kg (adult 75mg) 6H oral.

### Tripotassium dicitratobismuthate See bismuth subcitrate.

### Triptorelin Adult (NOT/kg). Depot: 3.75-4.2mg IM every 28 days.

### Long acting: 11.25mg IM every 12wk. .

### Trisodium edetate 40-70mg/kg (max 3g) IV over 6hr daily for 5

### days; max 3 courses each 2 days apart.

### Trometamol (THAM) ml of 0.3 molar (18g/500ml) soltn = (Wt in

### kg) x BE; give half this IV over 30min, then repeat if reqd.

### Tropicamide 0.5%, 1%: 1 drop/eye, repeat after 5min.

### Tropisetron 0.1mg/kg (adult 5mg) slow IV just before

### chemotherapy, then oral 12-24H.

### Trospium chloride 0.4mg/kg (adult 20mg) 12H oral. .

### Trovafloxacin 4mg/kg (adult 200mg) daily oral. Severe inftn: 6mg/kg

### (adult 300mg) daily oral.

### Tryptophan, L isomer Adult (NOT/kg) 1-2g 8H oral.

### Tyloxapol See colfosceril palmitate.

### Tulobuterol 0.04mg/kg (adult 2mg) 8-12H oral.

### Typhoid vaccine, oral (Vivotif) Live. 1 cap oral days 1, 3, 5 and (for

### better immunity) 7. Boost yearly.

### Typhoid vaccine, parenteral, polysaccharide (Typherix, Typhim Vi)

### Inactivated. >5yr: 0.5ml IM once. Boost 3yrly.

### Ubidecarenone 1-3mg/kg (adult 50-150mg) 12H oral.

### Uracil See tegafur + uracil.

### Urea 10% cream: apply 8-12H.

### Urofollitrophin See follicle stimulating hormone.

### Urokinase 4000u/kg IV over 10min, then 4000u/kg/hr for 12hr

### (start heparin 3-4hr later). Blocked cannula: instill 5000-25000u

### (NOT/kg) in 2-3ml saline for 2-4hr. Empyema: 2ml/kg of 1500u/ml

### in saline, position head up/down and right side up/down 30min

### each, then dr

### Ursodeoxycholic acid 5-10mg/kg (adult 200-400mg) 12H oral.

### Ursodiol See ursodeoxycholic acid.

### Valaciclovir 20mg/kg (adult 1g) 8H oral. Genital herpes (NOT/kg):

### treatment 500mg 12H, prevention 500mg daily (<10 episodes/yr) 1g

### daily (>9 episodes/yr). Orolabial: 40mg/kg (adult 2g) 12H for 2

### doses.

### Valcyte Adult (NOT/kg): 900mg 12H oral for 3wk, then 900mg

### daily.

### Valdecoxib Adult(NOT/kg): 10mg daily (arthritis), 20mg 12H

### (dysmenorrhoea) oral.

### Valganciclovir Adult (NOT/kg): 900mg 12H oral with food for 21

### days, then 900mg daily.

### Valproic acid, valproate See sodium valproate.

### Valrubicin Adult (NOT/kg): 800mg wkly x6 intravesical.

### Valsartan 0.8-3mg/kg (adult 40-160mg) daily oral. See also

### amlodipine + valsartan.

### Vancomycin 10mg/kg (adult 500mg) 6H IV over 1hr, or 1g 12H in

### adult IV over 2hr. Newborn: 10mg/kg 8H IV over 1hr. C.difficile:

### 10mg/kg (adult 500mg) 6H oral. Intraventric (NOT/kg): 10mg 48H.

### Trough 5-10mg/L (peak 20-40mg/L).

### Vardenafil Erectile dysfunction (NOT/kg): 10mg (range 5-20mg)

### oral 1hr before sexual activity (max once/day).

### Varenicline Adult (NOT/kg): 0.5mg oral daily for 3 days, 12H days

### 4-7; then 1mg 12H for 11wk (23wk if stopped smoking).

### Varicella vaccine (Varilix, Varivax) Live. 9mo-12yr: 0.5ml SC

### once. >12yr: 0.5ml SC stat, and 4-8wk later. See also Herpes

### zoster vaccine, and Immunolobulin zoster.

### Vasopressin, aqueous IM, SC: 2.5-10u 6-12H. IV: put 2-5u in 1L

### fluid, and replace urine output + 10% each hour. Hypotension (brain

### death, sepsis, post-bypass): 1u/kg in 50ml 5%dex-hep at 1-3ml/hr

### (0.02-0.06units/kg/hr) + adrenaline 0.1-0.2mcg/kg/min. GI hge:

### 6u/kg in 50ml at

### Vasopressin, oily 2.5-5u (NOT/kg) IM every 2-4 days. .

### Vecuronium ICU: 0.1mg/kg prn IV. Theatre: 0.1mg/kg stat, then

### 0.5-2mcg/kg/min; up to 10mcg/kg/min occasionally.

### Venlafaxine Adult (NOT/kg): 37.5mg 12H oral, incr if reqd to max

### 150mg 12H. Slow rel: 75mg daily oral, incr if reqd to max 225mg

### daily.

### Verapamil IV: 0.1-0.2mg/kg (adult 5-10mg) over 10min, then

### 5mcg/kg/min. Oral: 1-3 mg/kg (adult 80-120mg) 8-12H.

### Veregen 15% ointment: apply 8H for up to 16wk.

### Versenate See sodium calciumedetate.

### Verteporfin 6mg/m2 over 10min IV; 15min after start of infsn give

### diode laser of 689nm at 600mW/cm2 for 83sec.

### Vidarabine Eye ointment: x5/day until epithelialised, then 12H 7

### days. IV infsn: 10mg/kg/day 5-10 days (varicella-zoster),

### 15mg/kg/day 10 days (herpes encephalitis).

### Vigabatrin 40mg/kg (adult 1g) daily oral, incr if reqd to 80-

### 150mg/kg (max 4g) daily (given in 1-2 doses).

### Viloxazine 2-5mg/kg (adult 100-250mg) morning, and 2-3mg/kg

### (adult 100-150mg) noon oral. Elderly: 100mg daily.

### Vinblastine 6.5mg/m2 IV over 1 min every 1-4wk.

### Vindesine 3-4mg/m2 IV every 7-10day if WCC>2500/mm3.

### Vitamin A High risk (NOT/kg): 100,000iu (<8kg), 200,000iu

### (>8kg) oral or IM every 4-6mo. Severe measles: 400,000iu

### (NOT/kg) once. Cystic fib: 1500u daily (<3yr) 5000u daily (3-10yr)

### 10000u daily (>10yr) oral. >10,000iu daily or >25000u per wk may

### be teratogenic.

### Vitamin A, B, C, D compound (Pentavite, infant) <3yr (NOT/kg):

### 0.15ml daily, incr by 0.15ml/day to 0.45ml/day.

### Vitamin A, B, C, D compound (Pentavite, child) <3yr (NOT/kg):

### 2.5ml daily. >3yr (NOT/kg): 5ml daily.

### Vitamin B group Amp: IV over 30 min. Tab: 1-2/day.

### Vitamin B1 See thiamine.

### Vitamin B2 Metabolic disease: 50-150mg 12-24H oral.

### Vitamin B6 See pyridoxine.

### Vitamin B12 See hydroxocobalamin.

### Vitamin C See ascorbic acid.

### Vitamin D2 See ergocalciferol.

### Vitamin D3 See cholecalciferol.

### Vitamin E 1u = 1mg. Preterm babies, Coperol E (NOT/kg): 40u

### (2 drops) daily oral. CF, malabs: 50-100u (<3yr) 200-400u (>3yr)

### daily oral. Cholestasis: 50u/kg daily oral, incr if reqd in 50u/kg

### increments. A-beta-lipoproteinaemia: 35-70 u/kg 8H oral. HUS:

### 0.25g/m2 6H

### Vitamin K1 See phytomenadione.

### Vitamin K3 See menapthone sodium bisulphite.

### Vitamins, parenteral MVI-12 (for adult): 5ml in 1 litre IV fluid. MVI

### Paediatric, added to IV fluid: 65% of a vial (<3kg), 1 vial (3kg to

### 11yr).

### Vitaprem (RCH: Pentavite, folate, B12, C) 1ml daily oral.

### Voriconazole Oral, IV over 2hr: 8mg/kg (child >2yr) 200mg (adult

### <40kg) 400mg (adult >40 kg) repeated after 12hr, then 6mg/kg

### (child >2yr) 100mg (adult <40kg) 200mg (adult >40kg) 12H.

### Increase maintenance by 50% if required.

### Vorinostat Adult (NOT/kg): 400mg daily oral; may need to

### decrease to 300mg daily, or 300mg on 5 days a week.

### Warfarin Usually 0.2mg/kg (adult 5mg) stat, 0.2mg/kg (adult 5mg)

### next day providing INR <1.3, then 0.05-0.2mg/kg (adult 2-5mg)

### daily oral. INR usually 2-2.5 for prophylaxis, 2-3 for treatment.

### Beware drug interactions.

### Whole blood 6ml/kg raises Hb 1g%. 1bag = 400ml approx.

### Xamoterol 4mg/kg (adult 200mg) 12-24H oral.

### Xipamide 0.5-1.5mg/kg (adult 20-80mg) daily oral.

### Xylometazoline <6yr: 0.05% 1 drop or spray 8-12H. 6-12yr:

### 0.05% 2-3 drops or sprays 8-12H. >12yr: 0.1% 2-3 drops or sprays

### 6-12H.

### Yellow fever vaccine (Stamaril) Live. >12mo: 0.5ml SC once. Boost

### every 10yr.

### Yohimbine 0.05-0.1mg/kg (adult 2.7-5.4mg) 8H oral.

### Zafirlukast NOT/kg: 10mg (>7yr) 20-40mg (adult) 12H oral.

### Zalcitabine Usually 0.015mg/kg (adult 1mg) 12H oral.

### Zaleplon Adult (NOT/kg): 10mg (5-20mg) at night oral.

### Zanamivir Adult (NOT/kg): 10mg 12H for 5 days inhaled.

### Prophylaxis: 10mg daily inhaled.

### Ziconotide Adult (NOT/kg): 2.4mcg/day by intrathecal infusion,

### incr every 24-48hr to max 21.6mcg/day.

### Zidovudine (AZT) Preterm: 1.5mg/kg 12H IV, or 2mg/kg 12H oral to

### 2wk, then 2mg/kg 8H. Term newborn: 2mg/kg 6H oral, 1.5mg/kg 6H

### IV. Child: usually 180mg/m2 12H oral; 120 mg/m2 6H IV, or

### 20mg/m2/hr IV (range 90-180 mg/m2 6-8H IV). Adult (NOT/kg):

### usually 200mg 8H oral, or

### Zileuton Adult (NOT/kg): 600mg 6H oral.

### Zinc chloride 5.3mg/ml = 2.5mg/ml Zn = 38umol/ml Zn. 2-

### 4umol/kg/day (<1yr), 1umol/kg/day (child), 40-60umol/day (adult).

### Serum zinc 11-22 umol/l.

### Zinc sulphate (220mg cap = 50mg Zn = 765umol Zn). Deficiency,

### acroderm enteropath: initially 3mg/kg (adult 220mg) 8-12H oral,

### adjusted to achieve serum zinc 11-22umol/L (0.7-1.4mg/L).

### Diarrhoea child (NOT/kg): 10-20mg daily oral.

### Ziprasidone Adult (NOT/kg): 20mg 12H, incr if reqd to max 80mg

### 12H oral.

### Zoledronate 0.025-0.05mg/kg (adult 4mg) IV over 15min; usually

### repeated every 4wk. Postmenopausal osteoporosis (adult,

### NOT/kg): 5mg IV yearly.

### Zeledronic acid See zeledronate.

### Zolmitriptan Adult (NOT/kg): 2.5-5mg oral, repeat in 2hr if reqd;

### max 15mg in 24hr. Nasal: 5mg spray in each nostril, repeat in 2hr if

### reqd; max twice in 24hr.

### Zolpidem 0.1-0.4mg/kg (adult 5-20mg) nocte oral.

### Zonisamide 2mg/kg (adult 100mg) daily oral, incr if reqd after 2wk

### to 12H, then 3mg/kg (adult 150mg) 12h, then 4mg/kg (adult 200mg)

### 12H; rarely up to 6mg/kg (adult 300mg) 12H. Level 10-20mg/l.

### Zopiclone 0.1-0.3mg/kg (adult 5-15mg) at bedtime oral.

### Zotepine 0.5mg/kg (adult 25mg) 8H oral, adjusted every 4 days to

### 0.5-2mg/kg 8H.

### Zuclopenthixol 0.4-3.0mg/kg (adult 20-150mg daily)
