Neutrophils and macrophages use diverse membrane
receptors to recognize microbes, microbial
products, and substances produced by the host
in infections.
These receptors activate cellular responses
that
function to stimulate infl ammation and eradicate
microbes.
Neutrophils and macrophages use several types
of receptors to recognize microbes in the
blood and extravascular tissues.
when one receptor binds to the microbe, more
receptors are recruited.
Microbes are ingested into phagosomes.
Lysosomes, full of proteolytic enzymes come
and fuse with phagosome to form phagolysosome.
Lysosomal enzymes act on microbes.
Enzyme phagocyte oxidase produce Reactive
oxygen species from Oxygen.
iNOS produce Nitric Oxide while converting
arginine into citruline.
Lysosomal enzymes along with ROS and NO Kill
the microbes inside cell.
