The history of medicine is full of some huge
triumphs, but also some pretty terrible mistakes.
Like how, in the 1930s, a company out to make
a quick buck took a safe, effective drug and
managed to make it a killer.
But surrounding that tragedy are some pretty
fascinating stories: how a dye became a wonder
drug, how the US Food and Drug Administration
became what it is today, and how one scientist
walked home with a Nobel Prize.
The drug in question is called elixir sulfanilamide,
and it was briefly manufactured and sold by
the S. E. Massengill Company of Tennessee
in 1937.
But before this deadly elixir was concocted,
sulfanilamide had a good rep as an effective
drug all on its own.
Sulfanilamide is an antibiotic, so it’s
used to fight bacterial infections. It works
by interfering with bacteria’s ability to
make folic acid, which they need to reproduce.
It was derived from an earlier drug called
Prontosil, which had a vivid red color and
was actually developed by the dye industry.
In 1932, chemist Gerhard Domagk found that
this molecule wasn’t just pretty, it could
cure bacterial infections in mice.
And once Prontosil hit the market in 1935,
it quickly grew popular and saved a lot of
lives.
In fact, Prontosil and related compounds were
some of the earliest widespread antibiotics.
Penicillin had already been discovered, but
wasn’t easily available yet.
Now, further research showed that there were
two parts to the Prontosil molecule. One part
was the dye, and the other was the antibiotic.
The antibiotic half was sulfanilamide, which
researchers found could be used on its own,
mostly in powder or pill form. While it had
potential side effects, it was generally safe.
We actually still use sulfanilamide to treat
vaginal infections, though not very often
because there are other antimicrobials out
there nowadays.
But the problem was that sulfanilamide had
already been synthesized by chemists, and
the patent had expired. So anybody could make
and sell variants of it.
Enter the Massengill company, who found that
their customers liked their drugs in syrup
form.
They set out to make a liquid version of sulfanilamide,
and their researchers eventually found that
the powder would dissolve in diethylene glycol.
At the time, diethylene glycol was known as
a solvent. It has a sweet taste and smell,
and once the lab added some caramel and raspberry
flavoring, they figured they had a nice medicine
and released it as an antibiotic elixir.
Frankly, it sounds tastier than some cough
syrups I’ve had.
Except for one thing: diethylene glycol is
super poisonous.
Back then, there were one or two scientific
studies about its toxicity, but they weren’t
widely known. These days it’s used as antifreeze,
among other things, and we know it’s not
a sweet treat.
Inside your body, diethylene glycol takes
time to do its dirty work. At first, the symptoms
resemble drunkenness. But after several hours,
the poisoning gets worse.
While scientists aren’t exactly sure how
it kills, we do know it gets broken down by
your liver into a nastier form. From there,
it shuts down the kidneys and can affect the
nervous system too.
The instructions that shipped with the deadly
elixir sulfanilamide said to keep giving it
to patients until they got better.
Which means that some people were poisoned
by well-meaning loved ones who fed them antifreeze
for days or weeks until they succumbed, usually
from kidney failure.
In total, at least 105 people died. And if
Massengill had just fed it to a handful of
mice before shipping a bunch of it out, this
tragedy might have been prevented.
Before 1938, the United States FDA only had
the power to prevent adulteration and mislabeling.
You couldn’t, for example, sell tablets
of flour and say it was medicine. That was
against the law.
But you could sell something that was poison
with zero safety testing beforehand — as
long as it was what you said on the label.
The Massengill company’s elixir contained
exactly what they said it did: sulfanilamide
and diethylene glycol, with some water and
flavoring.
But they did technically break the law. They
called the stuff an elixir, but that word
was only supposed to be used for products
that contained ethyl alcohol. Massengill’s
syrup had none.
The FDA seized on this technicality. They
used it to track down the tainted medicine
& slap Massengill with an unprecedented fine.
If not for the fine print, they would have
been helpless, and many more people could
have died.
A new law was rushed through Congress in 1938,
giving the FDA increased power over drug safety.
That law is credited with preventing the infamous
drug thalidomide, which was found to cause
severe birth defects, from hitting US shelves
many years later.
In the aftermath of this tragedy and new legislation,
the chemist responsible for the antifreeze
elixir committed suicide. The senator who
sponsored the 1938 drug law died shortly after
it passed, reportedly of exhaustion.
Powder and pill forms of sulfanilamide were
still being made in labs and widely used as
antibiotics by American soldiers in World
War II.
As for Gerhard Domagk, developer of Prontosil,
he won the 1939 Nobel prize in physiology
or medicine for helping to usher in the antibiotic
era.
Because, really, prontosil, sulfanilamide,
and related compounds were used a lot at the
time, and can be safe and effective antibiotics.
Y’know, as long as you don’t take them
with antifreeze.
Thanks for watching this episode of SciShow!
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science and policy, you can check out videos
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